Postdocs

As postdocs in the Department of Pharmacology and Therapeutics, we are looking forward to creating an effective network of support for grad students and PIs. 

 

Postdoc/contact
Lab
Areas of expertise
Main Project

Abishankari Rajkumar
abishankari.rajkumar [at] mcgill.ca

Barbara Hales

and Bernard Robaire

  • Biochemistry
  • Reproductive Toxicology
  • Benchmark Concentration analyses
  • in vitro high content imaging analyses

Study the effects of organophosphate esters in vitro and in vivo

Carlos Agustin Isidro Alonso
carlos.alonso [at] mcgill.ca

Daniel Bernard

  • Mammalian reproduction
  • Cellular signaling pathways
  • Molecular Biology
  • Gamete function

Molecular mechanisms of FSH production in response to GnRH

Etienne Billard
etienne.billard [at] mail.mcgill.ca

Terry Hébert

  • Molecular Pharmacology
  • Peptide Chemistry
  • Medicinal Chemistry
  • Biochemistry

5-HT2AR/AMPAR Heteroreceptor Complex As A Mediator Of LSD Action

Juliana C. C. Dallagnol
juliana.dallagnol [at] mcgill.ca

Terry Hébert

  • Organic Chemistry
  • Medicinal Chemistry
  • Cell Signaling
  • Biased and allosteric modulators

Photoactivatable angiotensin II biased analogs targeting intracellular receptors

Kalai Mangai Muthukumarasamy
kalai.muthukumarasamy [at] mail.mcgill.ca

Stanley Nattel

  • Cardiac electrophysiology
  • Atrial Fibrillation
  • Myocardial fibrosis
  • human induced pluripotent stem-cell derived cardiomyocytes (hiPSC-CMs)

Role of calcium-activated potassium (KCa) channels in fibroblasts and myofibroblasts

Raphaël Bolteau
raphael.bolteau [at] mcgill.ca

Bastien Castagner

  • Organic Chemistry
  • Medicinal Chemistry
  • GPCR receptors
  • Pharmacological assays such as binding (radioligand displacement assays) and functionality assays (AMPc quantification by TR-FRET).
  • Molecular modeling / docking studies

Design, synthesize and evaluate promising second-generation inositol phosphate analogues against Clostridioides difficile infection

Simon Veyron
simon.veyron [at] mail.mcgill.ca

Jean-François Trempe

  • Biochemistry
  • X-ray crystallography
  • Molecular Pharmacology

Structure-based design of small-molecule activators of Parkin

Yanis Inglebert
yanis.inglebert [at] mail.mcgill.ca

Anne McKinney

  • Electrophysiology in vitro
  • Calcium imaging
  • Voltage imaging

Spike Timing-Dependent Plasticity at the spine level

Abishankari Rajkumar
I had graduated from the University of Ottawa with a Ph.D in Biochemistry. My thesis was focused on assessing the effects of polymorphism rs2419621 on the ability of women to lose weight following a diet replacement study. Using in vitro, ex vivo and human population statistics it was noted that individuals with the T allele had increased cellular and tissue respiration, paralleled with increased ability to lose fat mass. In 2018 I joined both Dr. Barbara Hales and Dr. Bernard Robaire’s labs, where I have been mainly focused on understanding the toxicity effects of emerging replacements on reproductive health. The following study uses cell lines to assess how bisphenols, plasticizers and organophosphate esters influence cellular phenotypic endpoints. Furthermore, we are currently in the process of analysing data from our rodent study which assessed the effects of an organophosphate ester mixture on reproductive health. This is an environmentally relevant mixture found in Canadian household dust.

Carlos Agustin Isidro Alonso
“I graduated as a Biologist in the National University of Mar del Plata in 2014, and got my PhD from the University of Buenos Aires in 2018. I became passionate about reproduction from the very beginning of my research career. I learned numerous techniques related to gamete handling and analysis from various mammalian species. During my postdoc I got involved in reproductive endocrinology, which led me to develop skills in molecular biology and tissue and cell culture, as well as extensive management of mice colonies.”

Etienne Billard
“After a B.Sc. in Chemistry/Biology and a M.Sc. in Drug Sciences at Université Blaise Pascal, (Clermont-Ferrand II, France), I did a PhD in Biology under the supervision of Dr. David Chatenet (INRS, Laval), undertaking the synthesis and pharmacological characterisation of allosteric modulators of the urotensinergic system, using techniques such as peptide synthesis, binding, BRET-based biosensors and ex-vivo aortic contraction experiments. After my graduation in 2018, I worked with Dr. Jean-François Masson (UdeM, Montreal) on the development of a Surface-Enhanced Raman Spectroscopy (SERS)-based instrument to determine the composition of street-drug samples for harm-reduction purposes. I started postdoctoral research under Terry’s lab in early 2020, focusing on the mechanisms of action of LSD, a psychoactive substance with therapeutic value regarding the treatment of major depression and anxiety disorders. My research investigates potential interaction/hetero-oligomerization between AMPA and 5-HT2A, the receptor that mediates hallucinogenic effects of LSD.”

Juliana C. C. Dallagnol
“My research has been focused on the design, synthesis and pharmacological evaluation of novel target-specific drug candidates. I have experience in the synthesis of small molecules and biopolymers (polysaccharides), glycoconjugates, macrocycles, peptides and peptidomimetics. I have worked with the identification of novel scaffolds as well as hit-to-lead optimization. I have experience working with cell-based assays, biochemistry and molecular biology techniques and the evaluation of toxicity, potency, and efficacy of drug candidates in vitro. Additionally, I have experience on using computational tools to evaluate ADME properties as well as to screen libraries of compounds and propose chemical modifications (docking and MD).”

Kalai Mangai Muthukumarasamy
I obtained my Ph.D in Cardiovascular Research at the University of Copenhagen, Denmark in 2019 with the support of Marie Skłodowska-Curie Actions-Innovative Training Network (Afib-TrainNet) fellowship. Afib-TrainNet, the European based consortium had the goal of investigating novel drug targets for atrial fibrillation (AF) and to improve the understanding of underlying mechanisms of AF. My project involved deciphering the regulation of PKA on small-conductance calcium-activated potassium channel type 3 (SK3), which is associated with clinical AF. I joined as a postdoctoral fellow in Dr. Stanley Nattel’s lab in late 2019 and I am studying the contribution of calcium-activated potassium channels to the physiology and pathophysiology of fibroblasts and its differentiated myofibroblasts form which play a major role in myocardial injury and repair.

Raphaël Bolteau
“Raphaël Bolteau obtained his Ph.D in Medicinal Chemistry at the University of Lille in 2020. He worked on the design, synthesis and pharmacological evaluation of A2A receptor antagonists either selective or with an additional action on the mGlu5 receptor for the potential treatment of neurodegenerative diseases. In 2021, he joined the Castagner Lab at McGill University, as a Postdoctoral Researcher. He is working on the design and synthesis of promising second-generation inositol phosphate analogues against Clostridioides difficile infection.”

Simon Veyron
“I defended my PhD in structural biochemistry at Université Paris-Saclay in 2018 and since moved to McGill to work as a x-ray crystallography expert. My current research focus on small-molecule activator of the human E3-Ubiquitin ligase Parkin but I also am in charge of the crystallography-related part of the lab. As a new project, I am currently trying to implement lipids in my team as a new tool to study proteins activity and structure."

Yanis Inglebert
I defended my PhD in cellular neuroscience at Université Aix-Marseille in 2018. After a first postdoc in France, I joined the Anne McKinney lab at McGill in april 2020. My research investigates several forms of synaptic plasticity at spine level in the hippocampus and the cortex. In particular, Spike Timing-Dependent Plasticity (or STDP). I am trying to understand how some spines can “learn” or “forget” more easily than others.

Troubleshooting, training, brainstorming…

If you are having difficulties in your research and need our help, we would be glad to get involved! See below the things that we can help you with.

 

Abishankari Rajkumar
abishankari.rajkumar [at] mcgill.ca

  • Cellular metabolism assays, Seahorse XF analyzer, Mitochondrial Respiration assays, Operetta high-content imaging analyses, BMD Express software (data analyses), cellular biology (cell culture; transfection; vector cloning), western blot, immunofluorescence imaging, confocal microscopy.

Carlos Agustin Isidro Alonso, PhD
carlos.alonso [at] mcgill.ca

  • Reproductive biology: Bovine, mouse and human sperm in vitro capacitation and assessment. Bovine and murine IVF and embryo culture. Mice sperm cryopreservation. Primary culture of oviductal epithelial cells and pituitary cells.
  • Cellular and molecular biology: cell line culture and transfection. Essential cloning skills and bacteria culture.
  • Immunology: Western blot, ELISA, Flow Cytometry, Immunocytochemistry.
  • Microscopy: Epifluorescence and confocal microscopy.
  • Mouse colony breeding and maintenance.

Etienne Billard
etienne.billard [at] mail.mcgill.ca

  • Protein-Protein Interaction: BRET/FRET experiments, Proximity Ligation Assay, Co-Immunoprecipitation.
  • Peptide/Small molecule synthesis, labeling, purification, and characterization
  • GPCR ligands characterization, including the detection of biased-signaling and allosteric modulation.

Juliana C. C. Dallagnol
juliana.dallagnol [at] mcgill.ca

  • Chemical labeling and derivatization for Microscopy, HPLC analyses and binding assays (radiolabeling);
  • Purification and analytical methods (HPLC, LC/MS-MS, affinity chromatography, electrophoresis);
  • Setting up in vitro assays for the evaluation of potency,
  • efficacy, allostery and biased signaling (functional selectivity), and subcellular location bias;
  • Drugs solubility (critical evaluation of physicochemical properties and clues to better solubilize/disperse your drug to guarantee homogeneity in your assay);
  • Chemical characterization (NMR, UV-vis, IR and mass spectroscopy);
  • Molecular modeling, docking and virtual screening;

Kalai Mangai Muthukumarasamy
kalai.muthukumarasamy [at] mail.mcgill.ca

  • Cardiac Electrophysiology - patch clamp, langendorff isolated heart perfusion (cardiomyocytes and fibroblasts isolation), primary cell culture and transfection, calcium imaging, measurement of cardiomyocyte contractility, immunofluorescence, hiPSC-CMs.

Raphaël Bolteau
raphael.bolteau [at] mcgill.ca

  • Organic chemistry (from literature to synthesis and characterization)
  • Purification of organic compounds (normal phase or reverse phase chromatographies, recrystallization…)
  • Medicinal Chemistry aspects (drug design, ADME properties, affinity vs selectivity, BHE crossing ….)
  • Pharmacological assays (radioligand displacement assays for GPCRs) and functional assays (AMPc quantification)
  • Molecular modeling / docking studies (AutoDock Chimera Vina, Discovery Studio or Molecular Forecaster)

Simon Veyron
simon.veyron [at] mail.mcgill.ca

  • Biochemistry : in bacteria protein expression, purification, activity assay, protein-lipid interaction, liposome synthesis.
  • Crystallography : crystallogenesis, x-ray diffraction, crystallography.

Yanis Inglebert
yanis.inglebert [at] mail.mcgill.ca

  •  Electrophysiology (patch clamp, field recording, calcium/voltage imaging, optogenetics….)

 

 


 

 

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