Tripartite McGill-Luxembourg-Beijing Partnership on Brain-Periphery Interactions in Prodromal Parkinson’s Disease

Headshots of Edward Fon and Julien Doyon.Co-Principal Investigators: Edward Fon, Julien Doyon
International partners: Xuanwu Hospital of Capital Medical University; Luxembourg Centre for Systems Biomedicine of the University of Luxembourg
HBHL funding (over 3 years): $720,000
HBHL award start date: January 1, 2021

Parkinson’s disease (PD) affects 2-3% of people over 65 years old. Symptoms relating to PD can begin decades before the classical signs of the disease are seen, such as slow movements and tremors. This long pre-PD phase is known as prodromal PD.

This project aims to better characterize Parkinson’s disease (PD) progression and mechanisms. A unique sharable database integrating clinical, genetic, biological and imaging data will be created, and the role of gut bacteria in prodomal PD will be analyzed. This knowledge could allow us to deliver therapies to patients with prodromal PD before motor symptoms set in, reducing the burden of neurological illness worldwide.

McGill Co-applicants

  • Jean-Baptiste Poline, The Neuro (Montreal Neurological Institute-Hospital)
  • Ziv Gan-Or, The Neuro (Montreal Neurological Institute-Hospital)
  • Ronald Postuma, The Neuro (Montreal Neurological Institute-Hospital)
  • Corinne Maurice, Microbiology & Immunology
  • Ken Dewar, Human Genetics
  • Samantha Gruenheid, Microbiology & Immunology
  • Alan C. Evans, McConnell Brain Imaging Center
  • Jean-Paul Soucy, McConnell Brain Imaging Center
  • Bratislav Misic, McConnell Brain Imaging Center
  • Thomas Durcan, The Neuro (Montreal Neurological Institute-Hospital)
  • Alex Gregorieff, Pathology
  • Jo Anne Stratton, The Neuro (Montreal Neurological Institute-Hospital)

Collaborators

  • Heidi McBride, The Neuro (Montreal Neurological Institute-Hospital), McGill
  • Louis Collins, McConnell Brain Imaging Centre, McGill
  • Alain Dagher, McConnell Brain Imaging Centre, McGill
  • Benjamin De Leener, Polytechnique Montréal
  • Yasser Iturria-Medina, McConnell BIC, McGill
  • Pedro Rosa-Neto, Research Centre for Studies in Aging, Douglas Research Centre, McConnell BIC, McGill
  • Piu Chan, Xuanwu Hospital of Capital Medical University, Beijing, China
  • Ting Ma, Xuanwu Hospital of Capital Medical University
  • Tao Wu, Xuanwu Hospital of Capital Medical University
  • Shu-Ying Liu, Xuanwu Hospital of Capital Medical University
  • Rejko Krüger, Luxembourg Center for Systems Biomedicine, University of Luxembourg
  • Paul Wilmes, Luxembourg Center for Systems Biomedicine, University of Luxembourg
  • Jens Christian Schwamborn, Luxembourg Center for Systems Biomedicine, University of Luxembourg
  • Anja Leist, University of Luxembourg
  • Enrico Glaab, Luxembourg Center for Systems Biomedicine, University of Luxembourg
  • Clarissa Gomes, Luxembourg Center for Systems Biomedicine, University of Luxembourg
  • Magali Perquin, Luxembourg Institute of Health
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