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Chemical Society Seminar: Thomas Maimone - Synthetic Studies Toward Complex Natural Products

16 Oct 2018 13:00

Concise total syntheses of biologically active natural products will be disclosed and the enabling synthetic tactics discussed. Emphasis will be placed on a discussion of complex meroterpenes and terpene-derived metabolites. The exploitation of oxidative synthetic processes, as well as new methods for complex polycycle synthesis, will be highlighted.

Chemical Society Seminar: Roger Linington - Integrated Methods for Bioactive Natural Product Discovery

30 Oct 2018 13:00

Although natural products have traditionally played an important role in therapeutic discovery and development, rediscovery of known compound classes is increasingly hampering novel compound development. 1 To address this issue, our laboratory is developing new methods for the direct mechanistic and chemical characterization of small molecules in complex mixtures....

CCVC Lecture Tour and Graduate Student Invited Lecturer: Sarah Reisman - Necessity is the Mother of Invention: Natural Products and the Chemistry They Inspire

6 Nov 2018 13:00

The chemical synthesis of natural products provides an exciting platform from which to conduct fundamental research in chemistry and biology. Our group is currently pursuing the synthesis of a number of structurally complex natural products, including the diterpenoids ryanodine, talatisamine, and pleuromutilin....

Chemical Society Seminar: Mark Stradiotto - Move Over Palladium: Developing PAd-DalPhos/Nickel-Catalysed C-N Cross-Couplings

20 Nov 2018 13:00

While palladium-based synthetic methods including C(sp2)-N cross-coupling (aka Buchwald-Hartwig amination) are useful, the cost and rarity of palladium provides motivation for the development of alternative protocols that make use of inexpensive and abundant base-metals....

Chemical Society Seminar: Jeffrey Moore - Autonomous Function for Life Cycle Control of Polymer Composites

27 Nov 2018 13:00

In this talk I will discuss the molecular design of organic structural materials that mimic the ability of living systems to protect, report, heal and even regenerate themselves in response to damage, with the goal of increasing lifetime, safety and sustainability of many manufactured items. I will emphasize recent developments in frontal ring-opening metathesis polymerization (FROMP) to manufacture composites with minimal energy consumption....

Tomlinson Teaching Lecture: Jeffrey Moore - Increasing Learning and Curiosity in Chemistry by Making the Molecular Sciences Personal

28 Nov 2018 13:00

The premedical competencies as outlined in a recent American Association of Medical Colleges (AAMC)-HHMI report on Scientific Foundation for Future Physicians calls for stronger connections between course content and the underlying principles in health and medicine....

QCAM: Chinedum Osuji -

4 Dec 2018 13:00

The 2018/2019 J.T. Donald Lecture: Carolyn Bertozzi - Targeting the Glycocalyx for Cancer Immune Therapy

11 Dec 2018 13:00

Successful tumors are able to evade the immune system, which is otherwise capable of killing transformed cells. Therapies that prevent this evasion have become revolutionary treatments for incurable cancers. This presentation will focus on our recent work targeting immune suppressive Siglec receptors and their sialylated glycan ligands, which are abundant within the cancer glycocalyx. We found that Siglec-ligand interactions can confer resistance to antibody-dependent cell cytotoxicity...