- Chemical Society Seminar
- Dept. of Chemistry
Radical reactions are routinely considered in synthetic planning, and highly active research continues on new ways to make and use radicals. Because the products of radical-molecule reactions are again radicals, such processes are perfectly suited to be run as sequential reactions (cascades). Likewise, because radicals can be oxidized or reduced, radical-ionic crossover reactions can be implemented. Such cascade reactions serve well the goal of step economy in organic synthesis....
Thiamin is an essential cofactor in all forms of life. While structurally simple, its biosynthesis is remarkably complex and presents a treasure trove of new biological chemistry. In my lecture, I will describe the different routes to the thiamin pyrimidine and thiazole and our initial results on thiamin catabolism and salvage.