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William J. Muller

Professor
Department of Biochemistry

Tyrosine kinase epidermal growth factor receptor (EGFR) family

Rosalind and Morris Goodman Cancer Center
The Cancer Research Building
1160 Pine Avenue
Office: Room 516; Lab: Room 507
Montreal, Quebec H3A 1A3
Tel: 514-398-5847; Lab: 514-398-4512
Fax: 514-398-6769
william [dot] muller [at] mcgill [dot] ca

1986 - PhD, McGill University

Canada Research Chair in Molecular Oncology

In the news

Key breast cancer gene found - Montreal Gazette (31 Aug 04)
Gene 'switches off' breast cancer - BBC news
Breast cancer can be reversed in laboratory mice, scientists report - Science Daily

Research interests

Slide of mouse mammary gland tissue showing small cancerous tumours.

The progression of the primary mammary epithelial cell to malignant phenotype involves multiple genetic events including the activation of dominant activating oncogenes and inactivation of specific tumour suppressor genes. Our laboratory has focused on the role of a class of receptor tyrosine kinases known as the epidermal growth factor receptor (EGFR) family in the induction of breast cancer. Elevated expression of the various EGFR family members has been observed in a large proportion of sporadic breast cancers and their derived cell lines. For example, amplification and overexpression of erbB-2/neu proto-oncogene is observed in 20-30% human breast cancer and is inversely correlated with the survival of the patient.

The major focus of our laboratory is to determine the relative contribution of the various EGFR family members and their coupled signaling pathways in ErbB-2 induced mammary tumour progression. Given the fact that germline inactivation of these signaling pathways results in either embryonic or perinatal lethality, we have used use Cre/Lox recombination system to specifically inactivate each of these signaling molecules members in the mammary epithelium of mice expressing activated erbB-2.

The results of these biochemical and genetic analyses will provide important insight in molecular basis for erbB-2 induced tumorigenesis and metastasis.

Publications - William J. Muller