Yu (Brandon) Xia

Our research is focused on computational biology, structural biology, and systems biology. We aim to construct genome-scale models of complex biomolecular systems such as proteins and protein networks with high spatial and temporal resolutions. By further analyzing these high-resolution models, we aim to elucidate the relationship between sequence, structure, function, and evolution of biomolecular systems, to probe design principles of biological molecules and networks, and to investigate systems biology mechanisms of disease. To achieve these aims, we develop and use diverse computational methods ranging from theory and simulation to modeling and informatics.