Sina Kheiri, PhD
Assistant Professor, Jarislowsky Research Chair in Translational Oncology

B.A.Sc., M.A.Sc, Ph.D.
- Microphysiological Systems
- Organ-on-a-Chip
- Tissue Engineering and Cancer Modeling
- Vasculogenesis & Angiogenesis
- Translational Oncology
- Computational Fluid Dynamics
I am developing microphysiological systems (MPS), which are engineered microfluidic devices that recreate the structure and function of human tissue at a small scale, allowing me to study disease and test therapies in a setting that closely mirrors human biology. My lab is working on building vascularized tumor MPS models, with a strong interest in upper gastrointestinal cancers, incorporating functional lymphatic vessels alongside blood vasculature, since these are the primary routes for both drug delivery and metastatic spread. To construct these tissues, I am using a narrative engineering approach: biomanufacturing strategies that assemble living building blocks, such as shape-defined tumor organoids, into structured, functional tissue architectures, giving me a level of control over tumor geometry and organization not achievable through cell culture alone. I am also combining these platforms with computational approaches, including computational fluid dynamics and machine learning, to guide device design and predict tissue behavior. The central goal of my research is to build MPS models that better reflect patient diversity by incorporating sex as a biological variable and recreating circadian rhythms within the tissue systems, both of which strongly influence drug metabolism and cancer progression.
- Interaction between tumor cells and the vascular and lymphatic microenvironment;
- Biomanufacturing of vascularized tissues;
- Sex- and time-informed precision medicine in cancer;
- Self-driving bio labs
Dr. Sina Kheiri is an Assistant Professor of Surgery at McGill University, where he holds the Jarislowsky Endowed Research Chair in Translational Oncology and a Junior Scientist appointment at the Research Institute of the McGill University Health Centre (RI-MUHC).
His main interest has always been using engineering phenomena and tools to better understand biology and control biological processes. This drove him to pursue a master’s degree in applied science at the University of British Columbia, followed by a PhD in Mechanical Engineering at the University of Toronto, co-supervised by Prof. Edmond Young and Prof. Eugenia Kumacheva, where he focused on microfluidics, organ-on-a-chip systems, and biofluid mechanics in cancer. Recognizing vascularization as a central, unmet challenge in building physiologically relevant tissue models, he then pursued postdoctoral training at MIT as an NSERC Postdoctoral Fellow, working with Prof. Roger Kamm and Prof. Ritu Raman, where he focused on mechanobiology and vascularized microphysiological systems (MPS).
Dr. Kheiri's research develops human-relevant tumor MPS, combining microfluidics, biomanufacturing, and computational approaches to recreate the structure and function of human tissues, with a strong interest in solid tumor and cancer models. His work has been recognized with the Douglas R. Colton Medal for Research Excellence, the CBMS Young Researcher Grant, and the Barbara and Frank Milligan Fellowship.
Google Scholar: https://scholar.google.ca/citations?user=QpfTyjoAAAAJ&hl=en
PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=sina+kheiri
1. 4D force patterning enables spatial control of angiogenesis. Kheiri S*, Shah J*, Chai P, Venkatesh SA, Flynn RA, Kamm RD, Raman R. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2026; PMID: 42406945 https://doi.org/10.1073/pnas.2532667123
2. GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling. Chai P, Kheiri S, Kuo A, Shah J, et al. Nature. 2026; PMID: 41606331 https://doi.org/10.1038/s41586-025-10052-8
3. Machine learning-assisted exploration of multidrug-drug administration regimens for organoid arrays. Yakavets I*, Kheiri S*, Cruickshank J, Hickman RJ, Rakhshani F, Aldeghi M, Rajaonson EM, Young EWK, Aspuru-Guzik A, Cescon DW, Kumacheva E. Science Advances 2025; PMID: 40737392 https://doi.org/10.1126/sciadv.adt1851
4. Microfluidic Platform for Generating and Releasing Patient-Derived Cancer Organoids with Diverse Shapes: Insight into Shape-Dependent Tumor Growth. Kheiri S*, Yakavets I*, Cruickshank J, Ahmadi F, Berman HK, Cescon DW, Young EWK, Kumacheva E. Advanced Materials. 2024; PMID: 39276011 https://doi.org/10.1002/adma.202410547
5. Integrating spheroid-on-a-chip with tubeless rocker platform: A high-throughput biological screening platform. Kheiri S, Chen Z, Yakavets I, Rakhshani F, Young EWK, Kumacheva E. Biotechnology Journal. 2023; PMID: 37436706 https://doi.org/10.1002/biot.202200621