Physiology Seminar: Precision genome editing to study protein function, genetic variation and drug development
In this talk, I will discuss the use of precision genome editing to advance our study of protein and gene function, alongside its translational application to characterize human genetic variation and to design exosite-directed drugs. In particular, I will present my research on 53BP1-mediated p53 regulation to exemplify how base editing screens increase the resolution and output of phenotype-genotype analyses. Also, I will highlight the current utility and future potential of a versatile precision genome editing platform for high throughput functionalization of variants of uncertain significance associated with human disorders. Finally, I will outline the application of base editing screens to drug development, focusing on the relevance of deep mutagenesis analyses combined with structural data to pinpoint exosites of druggable potential.
This seminar will take place both in-person and online, Details in attached poster