Physiology Seminar: Dr. Svetlana Komarova "The role of extracellular ATP and its derivatives in responses of bone cells to physical forces" "

Friday, October 27, 2023 11:00
McIntyre Medical Building Room 1034, 3655 promenade Sir William Osler, Montreal, QC, H3G 1Y6, CA

Physical forces are critical for the development, maintenance, and adaptation of various tissues in the body including bone. Bone adapts to mechanical loads through actions of bone cells: osteoclasts that specialize in bone resorption; osteoblasts that produce bone; and osteocytes embedded in bone matrix that sense mechanical forces and coordinate bone adaptation. ATP is a ubiquitous intracellular molecule critical for cellular bioenergetics, which is also one of the first signals released from bone cells that experience mechanical stimulation. Extracellular ATP is degraded by ecto-ATPases to form ADP and eventually adenosine. I will discuss our studies investigating how spatiotemporal signals provided by extracellular ATP and ADP may encode the information regarding severity, scale and proximity of the mechanical stimulus, allowing for a well-choreographed tissue responses to physical forces.

This seminar will take place in-person and online (details in attached poster below). All are welcome!

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