Physiology Seminar by Dr. Allen J. Ehrlicher: " Under pressure: compression-mediated nuclear mechanotransduction"

Friday, March 17, 2023 11:00to12:00
McIntyre Medical Building Room 1034, 3655 promenade Sir William Osler, Montreal, QC, H3G 1Y6, CA


Mechanotransduction, the conversion of mechanical stimuli into biochemical signals, is facilitated by numerous macromolecules, ion channels, and protein complexes within the cell. The nucleus itself also serves as a mechanosensor, integrating cytoskeletal and external stresses. In my research, we have found that nuclear strain mechanosensing appears to be a master control parameter for the regulation of Yes Associated Protein (YAP). In this talk, I will describe the biophysical regulation of YAP activity due to nuclear compression, how this is modulated by the structural protein Lamin A/C, and discuss some of the far-reaching applications from stem cell differentiation, to cancer and cellular aging.


This seminar will take place in-person and online (details in attached poster below)

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