Exploration of mechanisms underlying atrial fibrillation caused by myocardial ischemic damage: Confocal imaging of cell calcium, showing spontaneous Ca2+ release provoked by adrenergic stimulation in a cell from the ischemic border zone.

Stanley Nattel

Myelination of cultured dorsal root ganglion neuron axons by Schwann cells observed by immunostaining to myelin protein MBP (red) and a neurofilament (green). To the right an EM image of myelinating cultures shows compact myelin on large caliber axons.

Guillermina Almazan

Clostridium difficile causes serious nosocomial infections of the colon. Two toxins secreted by the bacteria are interesting therapeutic targets. 2014, CDC, Photo credit: Jennifer Hulsey

Bastien Castagner

Co-localization of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the mouse pituitary gland as detected by dual-label immunofluorescence.

Dan Bernard

Homology model of GABA-A receptor structure.

Derek Bowie

Spectrograph (frequency vs. time) of representative ultrasonic vocalizations emitted by adult male rats following systemic administration of amphetamine.

Paul Clarke

Exposure to increasing doses of an anticancer drug (B and C) during organogenesis induces oxidative stress in mouse embryos, as indicated by green fluorescent staining of 4-hydroxy-nonenal protein adducts

Barbara Hales

Gold nanoflowers in tumor cells and microglia.

Dusica Maysinger

Qualitative analysis of 8-oxodG (green) immunofluorescence on caudal spermatozoa from young and aged rats counterstained with DAPI showing staining with 8-oxodG-positive spermatozoa in the aged samples.

Bernard Robaire

Model depicting positive and negative interactions between P-TEFb and histone H2B ubiquitylation during transcript elongation.

Jason Tanny

Heterodimers of GPCRs can alter all aspects of their function as compared to parent homodimers.

Terry Hebert

The subunit of amyloid plaque fibrils, peptide Aβ, is generated from the amyloid precursor protein (APP). Aβ42 oligomers are intermediates in the pathway of fibril formation and correlate with the neurotoxicity and cognitive deficits of Alzheimer patients.

Gerhard Multhaup

Genome wide mapping of DNA methylation, using 2000 different probes, defines a landscape of methylation that characterizes liver cancer. These probes could serve as exquisite diagnostic tools. The density of methylation increases from red to green.

Moshe Szyf

The amyloid precursor protein (APP) was labeled with either YFP or CFP and interaction of both molecules was measured by FRET.

Lisa Marie Münter

Confocal microscopy image of a rat spinal cord Lamina I neuron labelled retrogradely from the parabrachial nucleus with cholera toxin subunit b (CTb - in red) which displays substance P receptor (NK-1r) immunoreactivity (in green) on the plasma membrane.

Alfredo Ribeiro-da-Silva

A theoretical model of how Alzheimer’s disease (AD) biomarkers become altered or abnormal as the disease progresses from a cognitively normal stage, to Mild Cognitive Impairment (MCI) to AD dementia.

Claudio Cuello

The epigenome is reprogrammed in the germline and early embryo, leaving them susceptible to exposures in utero and postnatally and some of these effects may be transmitted to the next generation.

Jacquetta Trasler

The 3D structure of parkin, a ubiquitin ligase involved in a form of Parkinson's disease, shows how REP, by binding RING1 and preventing binding of an E2 ubiquitin-conjugating enzyme, regulates transfer of ubiquitin to a catalytic site in the RING2 domain.

Jean-François Trempe

Neuropharmacology involves the study and treatment of debilitating diseases of the nervous system, such as Alzheimer's or Parkinson's disease, epilepsy, multiple sclerosis, chronic pain, mental depression and drug abuse. Investigations in this field are by definition multidisciplinary in nature. They address the fundamental mechanisms underlying drug action in the nervous system, and the knowledge already gained through the research of several of our staff members should lead to the discovery of novel treatments for these disorders.

Other colleagues are studying how certain drugs act to combat arrhythmias (abnormal heart rhythms). Infertility, a serious medical problem affecting 250,000 Canadians, is also under investigation in the Department. In focusing on male infertility, research being undertaken is aimed at improving our understanding of this condition. It also includes the development of strategies to improve methods of contraception with fewer side effects, including a male contraceptive pill.

As well, toxic effects of drugs on animal models, particularly in pregnancy and in the developing embryo are being studied.

Using molecular biological approaches including epigenomics, nanomedicine and receptor signalling, we are studying the mechanisms triggering pathological cell changes which cause cancer and many other diseases, to discover ways to control them. The possibility of using genetic elements as a new class of therapeutic agents is also being investigated.

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