Ryan Mailloux

Degrees

• BSc (Honours) - Biochemistry/Laurentian University

• PhD - Biomolecular Sciences/Laurentian University

Recruiting

Looking for a Postdoctoral Fellow - joint supervision with Professor Luis Agellon.

Having expertise in nutrient metabolism and redox biology would be viewed as an asset.

Short Bio

Professor Mailloux received his PhD in Biomolecular Sciences from Laurentian University in 2008. After conducting his postdoctoral research at the University of Ottawa and Carleton University/Health Canada, he served as an assistant professor on the tenure-track from 2015-2019 in the Department of Biochemistry at Memorial University of Newfoundland. Professor Mailloux was recruited by McGill University in 2019 and served as Director of the School of Human Nutrition from 2023-2025 wherein he established the Enhanced Reality Simulator for advanced dietetics training in the Clinical Nutrition Research Unit (CNRU), rat housing in the Small Animal Research Unit (SARU), and helped establish the MAPL facility. He also holds academic associate status in the McGill Department of Biochemistry, is the Chair of the Canadian Oxidative Stress Consortium, and serves as an Associate Editor for Free Radical Biology and Medicine. He currently has an H-index of 47 (SCOPUS, retrieved Sept 16, 2026) and 45 (Web of Science, retrieved Sept 16, 2026).  

Research Interests

His research focuses on understanding how mitochondria generate free radicals like hydrogen peroxide and use these reactive molecules in cell communication. Specifically, his work focuses on mitochondrial hydrogen peroxide in the liver, the redox regulatory mechanisms that control its production, and how controlled mitochondrial hydrogen peroxide production can be used it to maintain optimal liver health. Professor Mailloux’s group is also invested in understanding how defects in mitochondrial hydrogen peroxide production by liver mitochondria can contribute to the manifestation of hepatic diseases like metabolic dysfunction induced fatty liver disease (MALFD) and its progression to more advanced liver disorders like metabolic dysfunction-associated steatohepatitis (MASH) and hepatocellular carcinoma (HCC). Finally, his team discovered reversible redox modifications like S-glutathionylation and S-nitrosylation serve as a novel mechanism for the regulation of hydrogen peroxide production in liver mitochondria. His team is now collaborating with various groups to target these hydrogen peroxide-generating sites with different therapeutics to prevent and treat MAFLD and HCC.

Professor Mailloux has published 94 articles on the topics of mitochondrial bioenergetics, oxidative eustress and oxidative distress, redox homeodynamics, hydrogen peroxide production and how dysfunctional bioenergetics causes metabolic disorders. More information on his research program and publications can be found here:

SCOPUS: https://www.scopus.com/authid/detail.uri?authorId=8664226100

Webofscience: https://www.webofscience.com/wos/woscc/summary/d8775f2b-6a5b-4adf-9be7-22e24062a89e-e23f6cb0/relevance/1

Google Scholar: https://scholar.google.ca/citations?user=M9XKSHEAAAAJ&hl=en

Current Research

Professor Mailloux’s research focuses on understanding how cells produce reactive oxygen species for signaling in response to nutrient and metabolic stress, the role of membrane contact sites in regulating redox signals, and how metabolic diseases are caused by defects in redox signaling pathways. In addition, his research is focused on defining how dietary nutrient overload disrupts redox signaling networks in hepatocytes causing liver diseases and how redox signals control the metabolic reconfigurations necessary for macrophage polarization to the M1 phase and cancer cell transformation and metastasis.

Courses

Publications

*Mailloux, R.J., Treberg, J., Grayson, C. et al. Mitochondrial function and phenotype are defined by bioenergetics. Nat Metab (2023).

To view a list of Dr. Mailloux's publications, click here. Also available on PubMed.

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