Luis B. Agellon

Professor

T: 514-398-7862  | luis.agellon [at] mcgill.ca (Email) | Macdonald-Stewart Bldg MS2-043

Degrees

BSc, Biology, McMaster University, 1982
PhD, Biology, McMaster University, 1986

Short Bio

Luis Agellon received his BSc and PhD degrees from McMaster University and postdoctoral training at The Johns Hopkins University (USA).  He held faculty positions at Columbia University (USA) and University of Alberta before joining the faculty at McGill University. 

Research Interests

Our research looks at how nutrients and other compounds found in foods control genes in the body, and how ingestion of certain types of nutrients cause chronic diseases such as atherosclerosis, obesity, high blood pressure, diabetes and gallstone disease.  We also study how certain compounds that are naturally found in fruits and vegetables impact on gene function and promote health.  By understanding how these compounds affect metabolism, our lab hopes to develop new strategies that help to prevent or lessen the severity of chronic diseases. 

Current Research

Dr. Agellon’s research program is comprised of three themes encompassing regulation of gene function and cellular metabolism by nutrients and non-nutrient plant metabolites, cellular and organ function in health and disease, and development of in vivo models of metabolic disorders for discovery research and therapeutics development. Engineered in vivo models and cells are used to learn how nutrients and non-nutrient components of the diet are metabolized, how these compounds and their metabolites regulate gene expression and coordinate metabolic function in cells as well as in the whole organism, and how gene variations influence the efficiency of metabolism. The goal of the research program is to gain insights into the functional relationship between nutrients, genes, gene function and metabolism so that practical and effective strategies for promoting health and alleviating metabolic dysfunction can be achieved through optimized nutrition and use of bioactive components extractable from foods.

Courses

NUTR 307 Metabolism and Human Nutrition 3 Credits
    Offered in the:
  • Fall
  • Winter
  • Summer

NUTR 604 Integrated Metabolic Research 3 CreditsTaught only in alternate years
    Offered in the:
  • Fall
  • Winter
  • Summer

NUTR 695 Hum Nutr Research Orientation 1 Credits
    Offered in the:
  • Fall
  • Winter
  • Summer

NUTR 701 Doctoral Comprehensive Exam
    Offered in the:
  • Fall
  • Winter
  • Summer

NUTR 797 Course not available

Publications

To view a list of Dr. Agellon's publications, click here.

Selection of Recent Review Articles

Transport and biological activities of bile acids (PMID 23603607)

The rise of proteostasis promoters (PMID 27797166)

Coping with endoplasmic reticulum stress in the cardiovascular system (PMID 23020580)

Endoplasmic reticulum stress, genome damage, and cancer (PMID 25692096)

Efficacy of the porcine species in biomedical research (PMID 26442109)

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