Have you ever imagined that laying down on your bed may affect your fertility?
Lefèvre PLC, Wade M, Goodyer C, Hales BF, Robaire B. A Mixture Reflecting Polybrominated Diphenyl Ether PBDE) Profiles Detected in Human Follicular Fluid Significantly Affects Steroidogenesis and Induces Oxidative Stress in a Female Human Granulosa Cell Line. Endocrinology. 2016 157(7):2698-711. doi: 10.1210/en.2016-1106.
Less body fat for toddlers taking vitamin D
Supplement given during first year of life critical for muscle-mass development
T. J. Hazell, S. Gallo, C. A. Vanstone, S. Agellon, C. Rodd, and H. A. Weiler. Vitamin D supplementation trial in infancy: body composition effects at 3years of age in a prospective follow-up study from Montréal. Pediatr Obes. 2016 Feb 4. doi: 10.1111/ijpo.12105. [Epub ahead of print]
Homing in on the Cause of Molar Pregnancies
Reddy R, Nguyen NM, Sarrabay G, Rezaei M, Rivas MC, Kavasoglu A, Berkil H, Elshafey A, Nunez KP, Dreyfus H, Philippe M, Hadipour Z, Durmaz A, Eaton EE, Schubert B, Ulker V, Hadipour F, Ahmadpour F, Touitou I, Fardaei M, Slim R. The genomic architecture of NLRP7 is Alu rich and predisposes to disease-associated large deletions. Eur J Hum Genet. 2016 Mar 9. doi: 10.1038/ejhg.2016.9. [Epub ahead of print]
The father effect - Discovery of how environmental memories may be transmitted from a father to his grandchildren
Siklenka K, Erkek S, Godmann M, Lambrot R, McGraw S, Lafleur C, Cohen T, Xia J, Suderman M, Hallett M, Trasler J, Peters AHFM, Kimmins S. Disruption of histone methylation in developing sperm impairs offspring health transgenerationally. Science. 2015 Nov 6;350(6261):aab2006. DOI: 10.1126/science.aab2006
Early germ cells that will develop into sperm are of lower quality in aged males
Selvaratnam J, Paul C, Robaire B. Male Rat Germ Cells Display Age-Dependent and Cell-Specific Susceptibility in Response to Oxidative Stress Challenges. Biology of Reproduction. 2015; 93(3):72, 1–17. DOI 10.1095/biolreprod.115.131318.
Live births possible for women with recurrent molar pregnancies
Akoury E, Gupta N, Bagga R, Brown S, Déry C, Kabra M, Srinivasan R, Slim R. Live births in women with recurrent hydatidiform mole and two NLRP7 mutations. Reprod Biomed Online. 2015 Apr 16. pii: S1472-6483(15)00156-X. doi: 10.1016/j.rbmo.2015.03.011.
Novel Inheritable DNA Methylation Marks Found in the Genome May be Linked to Cancer and Autism
McGraw S, Zhang JX, Farag M, Chan D, Caron M, Konermann C, Oakes CC, Mohan KN, Plass C, Pastinen T, Bourque G, Chaillet JR and Trasler JM (2015) Transient DNMT1 suppression reveals hidden heritable marks in the genome. Nucleic Acids Research, 43(3):1485-97. doi: 10.1093/nar/gku1386
Bidirectional communication responsible for defective XY oocyte
Xu B, Noohi S, Shin JS, Tan SL, Taketo T (2014) Bi-directional communication with cumulus cells involved in the deficiency of XY oocytes in the components essential for proper second meiotic spindle assembly. Developmental Biology 385: 242-252. doi: 10.1016/j.ydbio.2013.11.004
Molar pregnancies linked to abnormal cytotrophoblast differentiation
Nguyen NM, Zhang L, Reddy R, Déry C, Arseneau J, Cheung A, Surti U, Hoffner L, Seoud M, Zaatari G, Bagga R, Srinivasan R, Coullin P, Ao A, Slim R. Comprehensive genotype–phenotype correlations between NLRP7 mutations and the balance between embryonic tissue differentiation and trophoblastic proliferation. J Med Genet. 2014 Sep;51(9):623-34. doi: 10.1136/jmedgenet-2014-102546.
A father’s diet matters!
Lambrot R, Xu C, Saint-Phar S, Chountalos G, Cohen T, Paquet M, Suderman M, Hallett M, Kimmins S. (2013). Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes. Nature Communications, 4, 2889. doi:10.1038/ncomms3889
ICSI at least as successful in cancer survivors!
García A, Herrero MB, Holzer H, Tulandi T, Chan P. Assisted reproductive outcomes of male cancer survivors. J Cancer Surviv. 2014 Oct 2. DOI: 10.1007/s11764-014-0398-7