Rat testis section showing the expression of Peroxiredoxin 6. From the laboratory of Cristian O'Flaherty.

Triple transgenic reporter mouse embryo with fluorescent markers for collagens that are important in skeletal development. From the laboratory of Barbara Hales.

Telomere signal & DNA damage after treatment with cisplatin. IMF of gamma H2AX (green), FISH detection of telomere signals (red), & DAPI (blue) in C-18-4 cells. From Robaire lab. (Biol Reprod. 2014; 90:72)

 

Sperm epigenome essential for normal development. Offspring of mice with abnormal epigenome lead to major craniofacial malformations in two subsequent generations. From the Kimmins & Trasler labs. 

KHDC3L (magenta) and alpha tubulin (green) in a human oocyte. From Rima Slim Laboratory (Akoury et al., 2014, Hum Reprod)

The Goodyer lab studies human growth hormone receptor (GHR) gene to create molecular “blueprint" that will allow researchers to define genetic alterations in children & adults who exhibit abnormal growth or metabolic disorders.

Single granulosa cell adjacent to oocyte. Transzonal projections emanate from the granulosa cell & physically link to the oocyte, enabling intercellular communication needed for oocyte growth. From the lab of H Clarke.

 

The Head lab studies the effects of environmental chemicals on avian development. They use their findings to try to understand the impact of environmental chemicals on wild species of birds in the field.

The Bernard lab investigates mechanisms controlling production of follicle-stimulating hormone by pituitary gonadotrope cells (red cells).

The Yamanaka lab, interested in how a single fertilized egg develops into a multicellular organism, uses mouse embryos and embryonic stem cells to study morphogenesis, cell allocation and cell lineage specification in development.

About Us

History

Founded by Dr. Bernard Robaire in 1982, the Centre for Research in Reproduction and Development is among the longest-standing research centres at McGill. Today, the Centre is home to more than 30 principal investigators, 60 graduate students, 40 fellows and research associates, and 20 technical support staff from 11 Departments, 3 Faculties, and 8 Divisions at the University. With such critical mass, the CRRD has established itself as one of the most productive and dynamic research hubs for young and established researchers committed to the science of reproduction and development.

The research programs of our members span a wide range of topics, including understanding the basic biological mechanisms that control developing eggs and sperm within the gonads, how the reproductive hormones are produced and exert their effects, how the developing embryo implants into the uterus and establishes communication with its mother, causes and cures for conditions such as pre-eclampsia and intra-uterine growth retardation, and the effects of environmental pollutants and disease on the development of the eggs and sperm and of the fetus. We use both animal model systems and human clinical studies to reach our research objectives.

Mission and Objectives

  1. Strengthening research in reproductive and developmental biology across McGill by supporting new research collaborations.
  2. Increasing the visibility of Centre members and activities through social media (FB, Twitter, LinkedIn) and our annual Research Day.
  3. Promoting interactions with local, regional, national, and international investigators and centres. 
  4. Building future research capacity by providing training opportunities and support for graduate studies and post-doctoral fellows in reproductive and developmental biology.

Funding Sources

Funding for the Centre comes from the Réseau Qébécois en reproduction (RQR) and from McGill (VPRIR and Faculty of Medicine).

Given the current funding environment, we are expecting budgetary shortfalls in the near future and are actively seeking new sources of funding. Please click here, if you are interested in making a donation or contact crrd [at] mcgill.ca for more information.

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