Frontotemporal Dementia & Neuropsychiatry

Principal Investigator: Dr. Simon Ducharme
Publications: PubMed, Google Scholar

The FTD & Neuropsychiatry Lab led by Dr. Simon Ducharme aims to develop clinical and therapeutic tools for neuropsychiatric disorders, focusing on major neurocognitive disorders. We are conducting translational studies using structural and functional imaging in frontotemporal dementia (FTD) to improve early diagnostic markers for this devastating disease. Our group is involved in several national and international neuroimaging studies on dementia, in addition to innovative clinical trials on Alzheimer’s disease and FTD.

People

Dr. David Benrimoh Dr. David Benrimoh MD Graduate Student
Tristin Best Tristin Best MSc Graduate student, IPN program
Dr. Simon Ducharme MD MSc FRCP(C) Principal Investigator
Dr. Jake Levy Dr. Jake Levy MD Graduate Student
Dr. Ana Manera Dr. Ana Manera MD Post-Doctoral Fellow
Jillian McCarthy Jillian McCarthy BSc Graduate Student
Mahdie Soltaninejad Graduate Student, IPN program
Teodora Yaneva Teodora Yaneva MSc Research Staff

 

Careers

Currently, there are no career opportunities in our lab. Thank you for your interest.

National and International Studies

Canadian Consortium on Neurodegeneration in Aging – Comprehensive Assessment of Neurodegeneration and Dementia (CCNA-COMPASS)

Genetic Frontotemporal Dementia Initiative (GENFI2)

Neuropsychiatric International Consortium for FTD (NIC-FTD)

Diagnostic and Prognostic Precision Medicine Algorithm for FTD (DIPPA-FTD)

Clinical Trials

For information on currently recruiting clinical trials on dementia is available here.

Publications

  1. Manera AL, Dadar M, Collins DL, Ducharme S; Frontotemporal Lobar Degeneration Neuroimaging Initiative. Deformation-based morphometry study of longitudinal MRI changes in behavioral variant frontotemporal dementia. Neuroimage Clin. 2019;24:102079. doi: 10.1016/j.nicl.2019.102079. Epub 2019 Nov 5. Pubmed PMID: 31795051.
  2. Ducharme S, Pearl-Dowler L, Gossink F, McCarthy J, Lai J, Dickerson BC, Chertkow H, Rapin L, Vijverberg E, Krudop W, Dols A, Pijnenburg Y. The Frontotemporal Dementia versus Primary Psychiatric Disorder (FTD versus PPD) Checklist: A Bedside Clinical Tool to Identify Behavioral Variant FTD in Patients with Late-Onset Behavioral Changes. J Alzheimers Dis. 2019;67(1):113-124. PubMed PMID: 30584146.
  3. Levy JP, Bocti C, Elie D, Paquet N, Soucy JP, Ducharme S. Bifrontal Hypermetabolism on Brain FDG-PET in a Case of C9orf72-Related Behavioral Variant of Frontotemporal Dementia. J Neuropsychiatry Clin Neurosci. 2019 Winter;31(1):92-94. PubMed PMID: 30404533.
  4. Benrimoh D, Pomerleau VJ, Demoustier A, Poulin S, Maltais JR, Brouillette J, Ducharme S. Why We Still Use "Organic Causes": Results From a Survey of Psychiatrists and Residents. J Neuropsychiatry Clin Neurosci. 2019 Winter;31(1):57-64. PubMed PMID: 30305004.
  5. Alhusaini S, Karama S, Nguyen TV, Thiel A, Bernhardt BC, Cox SR, Corley J, Taylor A, Evans AC, Star JM, Bastin ME, Wardlaw JM, Deary IJ, Ducharme S. Association between carotid atheroma and cerebral cortex structure at age 73 years. Ann Neurol. 2018 Oct;84(4):576-587. PubMed PMID: 30179274.
  6. McCarthy J, Collins DL, Ducharme S. Morphometric MRI as a diagnostic biomarker of frontotemporal dementia: A systematic review to determine clinical applicability. Neuroimage Clin. 2018;20:685-696. PubMed PMID: 30218900.
  7. Ducharme S, Price BH, Dickerson BC. Apathy: a neurocircuitry model based on frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2018 Apr;89(4):389-396. PubMed PMID: 29066518.
  8. Ducharme S, Bajestan S, Dickerson BC, Voon V. Psychiatric Presentations of C9orf72 Mutation: What Are the Diagnostic Implications for Clinicians? J Neuropsychiatry Clin Neurosci. 2017 Summer;29(3):195-205. PubMed PMID: 28238272.
  9. Ducharme S, Albaugh MD, Nguyen TV, Hudziak JJ, Mateos-Pérez JM, Labbe A, Evans AC, Karama S. Trajectories of cortical thickness maturation in normal brain development--The importance of quality control procedures. Neuroimage. 2016 Jan 15;125:267-279. PubMed PMID: 26463175.
  10. Ducharme S, Murray ED, Seiner SJ, Tayeb H, Legesse B, Price BH. Retrospective Analysis of the Short-Term Safety of ECT in Patients With Neurological Comorbidities: A Guide for Pre-ECT Neurological Evaluations. J Neuropsychiatry Clin Neurosci. 2015 Fall;27(4):311-21. PubMed PMID: 25658682.
  11. Ducharme S, Price BH, Larvie M, Dougherty DD, Dickerson BC. Clinical Approach to the Differential Diagnosis Between Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders. Am J Psychiatry. 2015 Sep 1;172(9):827-37. PubMed PMID: 26324301.
  12. Ducharme S, Dickerson BC. The neuropsychiatric examination of the young-onset dementias. Psychiatr Clin North Am. 2015 Jun;38(2):249-64. PubMed PMID: 25998114.
  13. Karama S, Ducharme S, Corley J, Chouinard-Decorte F, Starr JM, Wardlaw JM, Bastin ME, Deary IJ. Cigarette smoking and thinning of the brain's cortex. Mol Psychiatry. 2015 Jun;20(6):778-85. PubMed PMID: 25666755.
  14. Ducharme S, Albaugh MD, Hudziak JJ, Botteron KN, Nguyen TV, Truong C, Evans AC, Karama S. Anxious/depressed symptoms are linked to right ventromedial prefrontal cortical thickness maturation in healthy children and young adults. Cereb Cortex. 2014 Nov;24(11):2941-50. PubMed PMID: 23749874.
  15. Ducharme S, Guiot MC, Nikelski J, Chertkow H. Does a positive Pittsburgh Compound B scan in a patient with dementia equal Alzheimer disease?. JAMA Neurol. 2013 Jul;70(7):912-4. PubMed PMID: 23689280.
  16. Ducharme S, Hudziak JJ, Botteron KN, Albaugh MD, Nguyen TV, Karama S, Evans AC. Decreased regional cortical thickness and thinning rate are associated with inattention symptoms in healthy children. J Am Acad Child Adolesc Psychiatry. 2012 Jan;51(1):18-27 PubMed PMID: 22176936.
  17. Le Blanc G, Jetté Pomerleau V, McCarthy J, Borroni B, van Swieten J, Galimberti D, Sanchez-Valle R, LaForce R Jr, Moreno F, Synofzik M, Graff C, Masellis M, Tartaglia MC, Rowe JB, Vandenberghe R, Finger E, Tagliavini F, de Mendonça A, Santana I, Butler C, Gerhard A, Danek A, Levin J, Otto M, Frisoni G, Sorbi S, Rohrer JD, Ducharme S; Genetic Frontotemporal Dementia Initiative (GENFI). Faster Cortical Thinning and Surface Area Loss in Presymptomatic and Symptomatic C9orf72 Repeat Expansion Adult Carriers. Ann Neurol. 2020 Jul;88(1):113-122
  18. Ducharme S, Dols A, Laforce Jr R, Devenney E, Kumfor F, van den Stock J, Dallaire-Théroux C, Seelaar H, Gossink F, Vijverberg E, Huey E, Vandenbuicke M, Masellis M, Trieu C, Onyike C, Caramelli P, de Souza L, Santillo A, Landqvist Waldö M, Landin-Romero R, Piguet O, Kelso W, Eratne D, Velakouli D, Ikeda M, Perry D, Pressman P, Boeve B, Vandenberghe, R, Mendez M, Azuar C, Levy R, Le Ber I, Baez S, Lerner A, Ellajosyula R, Pasquier F, Galimberti D, Scarpini E, van Swieten J, Hornberger M, Rosen H, Hodges J, Diehl-Schmid J, Pijnenburg Y. Recommendations to Distinguish Behavioural Variant Frontotemporal Dementia from Psychiatric Disorders. Brain. 2020 Jun 1;143(6):1632-1650.

Complete list of publications.

Media and Lab News

Dr. Ducharme was interviewed on pathological laughing and crying in the context of the Joker movie.

Research work from recent laboratory graduate Dr. Saud Alhusaini was featured in Neurology Today.

Dr. Ducharme was interviewed on TVA’s Salut Bonjour on the topic of clinical trials in dementia.

Dr. Ducharme was interviewed for the event Youth and Young Adult Mental Health and Wellness (Sept, 2020) produced by the Montreal General Hospital Foundation.

Dr. Ducharme was interviewed on FTD and managing challenging behaviour.

Resources and Information

For graduate student applications please send your CV to teodora.yaneva [at] mcgill.ca (Mrs. Teodora Yaneva).

For clinical Neuropsychiatry elective rotations, please see here.

FTD vs PPD [checklist]

Funding and Other Partners

                           

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