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Student art exhibition to highlight McGill Bicentennial

The Faculty of Science is celebrating McGill’s 200th anniversary with a student art exhibition on the theme of “Science!”. McGill students at all levels and all faculties are invited to submit works in any medium, expressing what science means to them.

Faculty of Science bicentennial committee member, Torsten Bernhard, says the aim of the exhibition is to celebrate science in all its forms.

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Published: 12 Jan 2021

Dr. Strauss publishes article in the Journal of Cell Biology: Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

Glucose homeostasis and growth essentially depend on the hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand–receptor interactions. While biochemistry predicts two distinct insulin binding sites, 1 and 2, recent structural analyses have resolved only site 1.

Published: 17 Feb 2020

Dr. Charles E. Smith continues long-standing collaborative investigations with Dr. James Simmer and Dr. Jan Hu from the University of Michigan

Dr. Charles E. Smith continues long-standing collaborative investigations with Dr. James Simmer and Dr. Jan Hu from the University of Michigan about how ameloblasts coordinate their activities to produce the protective enamel covering of teeth as well as flawed responses that occur from these cells when matrix formation/signaling is disrupted by genetic alterations.

Below is a list of recent publications:

Published: 28 Nov 2019

Dr. McPherson's Lab has developed a protocol to easily assess the specificity of antibodies—and hopefully stem some of the reproducibility crisis.

Peter S. McPherson

Opinion: Scientists Need to Demand Better Antibody Validation

My lab has developed a protocol to easily assess the specificity of antibodies—and hopefully stem some of the reproducibility crisis.

 

Click here to read the full article.

Published: 30 Oct 2019

Reinhardt lab receives funding from the prestigious Marfan Foundation (USA) to explore the connection between diet and disease development in Marfan syndrome

Reinhardt lab receives funding from the prestigious Marfan Foundation (USA) to explore the connection between diet and disease development in Marfan syndrome. Congratulations!

Published: 8 Oct 2019

Dr. Sandra Miller published an article in Current Trends in Immunology

TITLE: Augmentation of cell numbers and function in the immune system by in vivo administration of North American (NA) ginseng (Panax Quinquefolium): Assessment in normal and cancer-bearing infant, juvenile, adult and elderly mice

Published: 7 Oct 2019

Reinhardt lab published new mechanisms in elastic fiber formation in the Proceedings of the National Academy of Sciences of the United States of America (PNAS)

Title: Fibulin-4 exerts a dual role in LTBP-4L–mediated matrix assembly and function

Published: 30 Sep 2019

Amal Seffouh, a Postdoctoral Fellow in the Ortega lab, publishes her most recent work about the role of RbgA in the maturation of the 50S ribosomal subunit

Amal Seffouh, a Postdoctoral Fellow in the Ortega lab, publishes her most recent work about the role of RbgA in the maturation of the 50S ribosomal subunit.

 

Click here to read the paper.

 

Published: 9 Sep 2019

Congratulations to Dr. Marc McKee for receiving the ASBMR 2019 Adele L. Boskey Award!

Congratulations to Dr. Marc McKee for receiving the ASBMR 2019 Adele L. Boskey Award! The Adele L Boskey Esteemed Award for Bone and Mineral Research recognizes an American Society for Bone and Mineral Research member for outstanding and major scientific contributions, leadership and mentorship in the area of bone and mineral research especially in the areas of mechanisms of mineralization, bone mineral, bone quality, and mechanobiology.

Published: 13 Aug 2019

Aida Razi’s last PhD thesis chapter now published online in the Nucleic Acids Research journal. This publication features the first cryo-EM structures obtained by the Ortega lab in the Titan Krios microscope at FEMR-McGill

Aida Razi’s last PhD thesis chapter now published online in the Nucleic Acids Research journal. This publication features the first cryo-EM structures obtained by the Ortega lab in the Titan Krios microscope at FEMR-McGill.

 

Read the paper at https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz571/5527280?searchresult=1

Published: 4 Jul 2019

Dr. Kelly Sears is awarded the Microscopical Society of Canada Technologist Award 2019

Dr. Kelly Sears, Research Manager at the Facility for Electron Microscopy Research (FEMR) is awarded the Microscopical Society of Canada Technologist Award 2019. This award recognizes his passion and dedication to FEMR research mission. Congratulations!

 

Published: 15 May 2019

Deanna MacNeil from the Autexier lab establishes how an imbalance favoring telomerase RNA degradation over correct maturation is causative for the premature aging telomere biology disorder dyskeratosis congenita.

The telomerase holoenzyme responsible for maintaining telomeres in vertebrates requires many components in vivo, including dyskerin. Dyskerin binds and regulates the accumulation of the human telomerase RNA, hTR, as well as other non-coding RNAs that share the conserved H/ACA box motif.

Published: 23 Apr 2019

Reinhardt lab receives 5-year CIHR grant to investigate extracellular matrix-mediated regulation of microRNAs in health and disease.

Reinhardt lab receives 5-year CIHR grant to investigate extracellular matrix-mediated regulation of microRNAs in health and disease. Congratulations!

Published: 24 Jan 2019

Reinhardt lab establishes a new paradigm how extracellular fibrillin-1 regulates intracellular microRNAs and cell function

Fibrillins are the major components of microfibrils in the extracellular matrix of elastic and non-elastic tissues. Fibrillin-1 contains one evolutionarily conserved RGD sequence that mediates cell–matrix interactions through cell-surface integrins. The Reinhardt lab presents a novel paradigm how extracellular fibrillin-1 controls cellular function through integrin-mediated microRNA regulation.

Published: 8 Jan 2019

A new collaboration between the Reinhardt group and the Mantovani group at Laval University leads to the production of physiological-like vascular scaffolds published in Biomaterials.

One of the tightest bottlenecks in vascular tissue engineering is the lack of strength and elasticity of engineered vascular wall models caused by limited elastic fiber deposition. In this study, collagen gel-based scaffolds were cellularised with vascular smooth muscle cells (SMCs) and supplemented with human plasma fibronectin (FN), a known master organizer of several extracellular matrix (ECM) fiber systems.

Published: 9 Aug 2018

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