The Neuro. Montreal Neurological Institute
3801 Rue University, Montréal, QC H3A 2B4
Topics
* Basic mathematics for pharmacokinetic modeling
* Introduction to PET physics
* Introduction to pharmacological principles relevant to PET imaging
* Theory and application of reversible and irreversible compartment models
* Reference tissue and graphical/regression approaches to parameter estimation
* Applications to receptor systems, misfolded proteins, blood flow and glucose metabolism
* Hands on exercises with simulation software designed expressly for the course.
List of tutors
- Olivier Barret — (France)
- Ronald Boellaard — (Netherlands)
- Rich Carson — (USA)
- Sandeep Golla — (Netherlands)
- Bob Innis — (USA)
- Mark Lubberink — (Sweden)
- Gitte Moos-Knudsen — (Denmark)
- Marc Normandin — (USA)
- Julie Price — (USA)
- Mark Slifstein — (USA)
- Paolo Zanoti-Fregonara — (France)
| FEE TYPE | Price |
|---|---|
| Students (graduate and undergraduate(a) | CAD 540 |
| Academic (Faculty and post-doc) | CAD 810 |
| Industry | CAD 1080 |
|
All prices in CAD, taxes applicable for Canadian registrants (a) Proof of student status required |
|
May 16, 2024
| Theme | Time | Topic |
|---|---|---|
| Breakfast | 8:30 | |
| Primer 1 | 9:00 | Physics - Primer |
| 9:00 | Math - Primer | |
| 9:00 | Pharmacology | |
| Primer 2 | 10:00 | Physics - |
| 10:00 | Math - | |
| 10:00 | Pharmacology - | |
| 11:00 | Coffee + Software Installation | |
| Modeling Basics | 11:30 | Images, Image processing, ROIs, Partial Volume |
| 12:00 | Data Types, Input Functions, Time Activity Curves, Calibration | |
| 12:30 | Lunch and group photo | |
| 13:30 | Computer Exercise 1A,B,C: Exponentials, Convolutions | |
| 14:00 | Extraction and Blood Flow | |
| 14:30 | One-Tissue and Two-Tissue Compartment Models | |
| 14:30 | One-Tissue and Two-Tissue Compartment Models | |
| 15:00 | Coffee | |
| 15:15 | Receptor Kinetics | |
| 15:45 | Computer Exercise 2: Models and Rate Constants | |
| 16:15 | In-Vitro/In-Vivo Receptor Binding | |
| 16:45 | Irreversible Kinetics | |
| 17:15 | Questions/Discussion | |
| 17:45 |
Day 1 - Close Dinner - Ballroom, PGSS Thomson House, Rue McTavish |
May 17, 2024
| Theme | Time | Topic |
|---|---|---|
| Data Fitting, Simplified Methods, Applications | 8:30 | Light breakfast |
| 9:00 | Questions/Feedback | |
| 9:30 | Parameter Estimation and Model Selection | |
| 10:00 | Computer Exercise 3: Parameter Estimation | |
| 10:30 | Coffee | |
| 11:00 | Reference Tissue Methods | |
| 11:30 | Computer Exercise 4 (5 in software) Reference tissue methods | |
| 12:00 | Data Transformation for Regression (Logan, Patlak, Ichise) | |
| 12:30 | Lunch | |
| 13:30 | Computer Exercise 5 (4 in software): Linear Methods | |
| 14:00 | FDG and Glucose Metabolism | |
| 14:30 | Neuroinflammation Imaging | |
| 15:00 | Coffee | |
| 15:30 | Receptor Kinetics - In Vivo Pharmacology | |
| 16:00 | Computer Exercise 6 (8 in software): Distribution Volumes | |
| 16:15 | Tau imaging | |
| 16:45 | Synaptic Vesicle Imaging | |
| 17:00 | Blood Flow and Quantitative Imaging in Cardiology | |
| 17:30 | Day 2 - Close Dinner Cruise (time and transportation to be updated) |
May 18, 2024
| Theme | Time | Topic |
|---|---|---|
| Data Fitting, Simplified Methods, Applications | 8:00 | Light breakfast |
| 8:30 | Breakout Session with Tutors | |
| 9:30 | Coffee | |
| 10:00 | Breakout Highlights | |
| 10:45 | Exploring Kinetics with the NeuroExplorer | |
| 11:00 | Exploring Kinetics with the NeuroExplorer | |
| 11:30 | Review: The Beautiful World | |
| 12:10 | Review: The Real World | |
| 12:30 | Day 3 - Lunch and close |
