Publications (2009 - 2019)

 

Peer-reviewed articles

Vaniotis G, Moffett S, Sulea T, Wang N, Elahi SM, Lessard E, Baardsnes J, Perrino S, Durocher Y, Frystyk J, Massie B, Brodt P. Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties. Sci Rep., 8(1):17361, 2018.

Vaniotis G., Rayes, RF., Qi, S., Milette, S., Wang, S., Perrino, S.,  Nyström, N., He Y., Lamarche-Vane N., and Pnina Brodt.  Collagen IV-conveyed signals regulate cytokine production and promote liver metastasis  Oncogene, doi: 10.1038/s41388-018-0242-z. [Epub ahead of print], 2018.

Rayes, R., Fernandez, M.C., Milette, S., Wang, N., Bourdeau, F.,  Ham, B., Yakar , S., and Brodt, P. Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency, Oncotarget, 9(21):15691-15704, 2018.  

Van Dam, P-J, Van der Stok, EP., (+ 27 authors), Brodt P., Reynolds AR and Vermeulen, PB.   International consensus guidelines for scoring the histopathological growth patterns of liver metastasis- British Journal of Cancer, 117(10):1427-1441, 2017.  

Millete, S., Sicklick, JK., Lowy, AM., and Brodt P., Molecular Pathways: Targeting the microenvironment of liver metastases. Clin. Cancer Research – Invited Review, doi: 10.1158/1078-0432.CCR-15-1636. [Epub ahead of print], 2017.

Fernandez, M.C., Rayes, R., Ham, B., Wang, N., Bourdeau, F., Xu, J., Kisselova, T. and Brodt, P. (2016). The type I Insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells. Oncotarget, 8(32): 52281–52293, 2017.

Brodt, P., Role of the microenvironment in liver metastasis: from pre- to prometastatic niches- Clinical Cancer Research - Invited review,  15;22(24): 5971-5982, 2016.

Ham, B., Fernandez, M.C., D’Costa, Z. and Brodt, P. The diverse roles of the TNF axis in cancer progression and metastasis. Trends in Cancer Research - Invited Review, 11:1-27, 2016. 

Ham, B., Wang, N., D’Costa, Z., Fernandez, M. C., Bourdeau, F., Auguste, P., Illemann, M., Eefsen, R. L., Høyer-Hansen, G., Vainer, B., Evrard, M., Gao, Z-H., and Brodt, P. TNF receptor-2 facilitates an immunosuppressive microenvironment in the liver to promote the colonization and growth of hepatic metastases. Cancer Research, 75(24):5235-47, 2015.

Li, S., Pinard, M., Wang, Y., Yang, L., Lin, R., Hiscott, J., Su, B., and Brodt, P. Crosstalk between the TNF and IGF pathways enhances NF-κB activation and signaling in cancer cells. Growth Hormone & IGF Research, 25(5): 253-261, 2015.

Wang, N., Rayes, R.F., Elahi, S.M., Lu, Y., Hancock, M.A., Massie, B., Rowe, G.E., Aomari, H., Hossain, S., Durocher, Y., Pinard, M., Tabariès, S., Siegel, P.M., Brodt, P. The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. Molecular Cancer Therapeutics, 14(4): 982 – 993, 2015.

Van den Eynden, G.G., Bird, N.C., Dirix, L.Y., Eefsen, R.L., Gao, Z-H., Høyer-Hansen, G., Illemann, M., Majeed, A.W., Metrakos, P., Reynolds, A.R., Vainer, B., van Dam, P-J., Van Laere, S.J., Vermeulen, P.B., Vidal-Vanaclocha, F. and Brodt, P. Tumor stromal phenotypes define VEGF sensitivity – Letter, Clinical Cancer Research, 20: 5140, 2014.

Seccareccia, E., Pinard, M., Wang N., Li, S., Burnier, J.V., Dankort, D., and Brodt, P. The inhibitor of kappa B kinase-epsilon regulates MMP-3 expression levels and can promote lung metastasis. Oncogenesis 3:e116, 2014.

Van den Eynden, G.G., Majeed, A.W., Illemann, M., Vermeulen, P.B., Bird, N.C., Høyer-Hansen, G., Eefsen, R.L., Reynolds, A.R. and Brodt, P. The multifaceted role of the microenvironment in liver metastasis: biology and clinical implications – Invite review - Cancer Research, 73(7): 2031-43, 2013.

Wang, N., Lu, Y., Pinard, M., Pilotte, A., Gilbert, R., Massie, B. and Brodt, P. Sustained production of a soluble IGF-I receptor by gutless adenovirus-transduced host cells protects from tumor growth in the liver. Cancer Gene Therapy, 20 (4): 229 - 236, 2013.

Seccarecia, E. and Brodt, P. The role of the insulin-like growth factor-I receptor in malignancy: An update – Invited review- Growth Hormone and IGF Research, 22 (6): 193 - 199, 2012.

Brodt, P. Surviving host innate immunity: Cancer cells can turn a deadly assault into an advantage. OncoImmunology - invited commentary OncoImmunology, 1(9): 1601–1603, Dec 2012.

Eefsen, R.L., Van den Eynden, G.G., Høyer-Hansen, G., Brodt, P., Laerum, O.D., Vermeulen, P.B., Christensen, J., Wettergren, A., Federspiel, B., Willemoe, G.L., Vainer, B., Østerlind, K. and Illemann, M. Histopathological growth pattern, proteolysis and angiogenesis in chemonaive patients resected for multiple colorectal liver metastases – J Oncol. 2012; 2012: 907971, 2012.

Arabzadeh, A., Chan, C., Nouvion, A-L., Breton, V., Benlolo, S., DeMarte , L., Turbide , C., Brodt, P., Ferri, L. and Beauchemin, N. Host-related Carcinoembryonic Antigen Cell Adhesion Molecule 1 Promotes Metastasis of Colorectal Cancer. Oncogene, 37: 849-60, 2012.

Li, S., Wang, N. and Brodt, P. Metastatic cells can escape the pro-apoptotic effects of TNF-alpha to increase autocrine IL-6/STAT3 signalling - Cancer Research, 72: 865-875, 2012.

Eichbaum, C., Meyer A.-S., Wang, N., Bischofs, E., Steinborn, A., Bruckner, T., Brodt, P., Sohn, C. and Eichbaum, M.H. Breast Cancer Cell-derived Cytokines, Macrophages and Cell Adhesion: Implications for Metastasis Anticancer Res. 10:3219-27, 2011.

Burnier, J.V., Wang, N., Michel, R.P., Hassanain, M., Li S., Lu, Y., Metrakos, P., Antecka, E., Burnier, M.N., Ponton, A., Gallinger, S. and Brodt P. Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis. Oncogene 30:3766-83, 2011.

Wu, Y., Brodt, P., Sun, H., Meji, W., Novosyadlyy, R., Nunez, N., Chen, X., Mendoza, A., Hong, S-H., Khanna, C. and Yakar, S. IGF-1 regulates the liver microenvironment in obese mice and promotes liver metastasis. Cancer Research 70 :57-67, 2010.

Li, S., Zhang, D., Yang, L., Burnier J.V., Wang, N., Lin, R., Lee E.R., Glazer, R.I. and Brodt, P. The IGF-I receptor can alter the matrix metalloproteinase repertoire of tumor cells through transcriptional regulation of PKC-alpha. Mol. Endocrinology 23(12):2013-25, 2009.

Jung, T., Castellana, D., Klingbeil P., Cuesta Hernández, I., Vitacolonna, M., Orlicki, D.J., Roffler, S.R., Brodt, P. and Zöller, M. CD44v6dependence of premetastatic niche preparation by exosomes. Neoplasia 11: 1093-1105, 2009.

McDonald, B., Spicer, J., Giannais, B., Fallavollita, L., Brodt, P. and Ferri, L. Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms. Int. J. Cancer, 125 :1298-1305, 2009.

Wang, N., Fallavollita, L., Nguyen, L., Burnier, J., Rafei, M., Galipeau, J., Yakar, S. and Brodt, P. Autologous bone marrow stromal cells genetically engineered to secret an IGF-I receptor decoy prevent the growth of liver metastases. Mol. Ther, 17:1241-9, 2009.

Abstracts

Chen, Y-H. M., Qi, S., Hashimoto,M., Perrino, S., Jabado, N., Brodt, P. Evaluation of an IGF-Trap for the Treatment of Pediatric High-Grade Gliomas. Cancer Research Program Research Day, Montreal, Canada, 2019.

Brodt P., Samani A.A., Zhu X. and Nalbamtoglu J. Glioma cells with downregulated IGF-IR expression can persist in the brain in a dormant state. Proc. AACR conference on Dormancy and Residual Disease- Montreal, Canada, 2018.

*Milette S, Perrino S., Wang N., Piccirillo C. and Brodt P. Estrogen promotes immune evasion in the liver to enhance metastatic expansion. Proc. AACR conference on Dormancy and Residual Disease, Montreal, Canada, 2018.

*Konda J.D., HashimotoM., ZhangJ., Fernandez M.C., Wang N., Perrino S., Montermini L., Rak J., Jean-Sebastien Pelletier, Andrew Lowy and Pnina Brodt. Pancreatic Ductal Adenocarcinoma-associated stellate cells promote a pro-metastatic microenvironment in the liver - Proc. Am. Assoc. Cancer Res., Chicago, United States, 2018.

Milette, S., Perrino, S., Wang, N., Brodt, P., Sex hormones regulate the immune microenvironment of liver metastases. Cell symposia: Human Immunity. Banff, Alberta, Canada, 2017.

Vaniotis, G., Rayes, RF., Qi, S., Milette, S., Bourdeau, F., Wang, N., Perrino, S., Lamarche-Vane, N., Brodt, P. Collagen IV-conveyed signals regulate cytokine production and promote liver metastasis. Cancer Research Program Research Day, Montreal, Canada, 2017.

Qi, S., Vaniotis, G., Wang, N., Brodt, P. CCL7 promotes cancer cell invasion by regulating invadopodia formation via CCR3 signaling. Cancer Research Program Research Day, Montreal, Canada, 2017.

Milette, S., Perrino, S., Wang, N., Brodt, P. The role of sex hormones in the response of the immune microenvironment to liver metastases. Cancer Research Program Research Day, Montreal, Canada, 2017.

Tsui, J., Vaniotis, G., Fernandez, MC., Brodt., P. Identification of resistance mechanisms to IGF-IR targeting in triple negative breast cancer.  Proc. Am. Assoc. Cancer Res., 2017.

Milette, S., Wang, N., Perrino, S., Brodt, P. Sex disparity in the response of the immune microenvironment to colon cancer liver metastases. Proc. Am. Assoc. Cancer Res., 2017.

Fernandez, M.C. and Brodt, P. An IGF-Trap inhibits metastasis of pancreatic ductal adenocarcinoma. Proceedings of the Molecular Therapeutics of Cancer Research Society, Seattle, United States, 2016.

Ham, B., D’Costa, Z., Wang, N., Fernandez, MC., Bourdeau, F., Auguste, Brodt., P. Regulation of the immunosuppressive microenvironment of liver metastases by TNFR2. Proc. Special Conference of the EACR/AACR/SIC, Florence, Italy, 2015.

Fernandez, MC., Rayes, RF, Xu, J., Kisseleva T., Yakar, S., Brodt, P. The IGF axis regulates hepatic stellate cell recruitment and activation during colorectal carcinoma liver metastasis.Proc. Am. Assoc. Cancer Res., 2015.

Ham, B., Auguste, P., Evrard, M., Wang, N., Bourdeau, F. and Brodt, P. Identification of a bone marrow-derived MDSC subset that promotes the growth of colon carcinoma liver metastases. Proc. Am. Assoc. Cancer Res., 2014.

Rayes, R.F., Burnier, J.V., Wang, N. and Brodt, P. A distinct gene expression program induced by extracellular matrix type IV collagen promotes liver metastasis. Proc. Am. Assoc. Cancer Res., 2014.

Rayes, R.F., Burnier, J.V., Wang, N. and Brodt, P. Regulation of site-specific liver metastasis by collagen IV-conveyed signals. Canadian Cancer Research Conference, Toronto, 2013.

Wang, N., Rayes, R., Lu, Y., Elahi, M., Qayum, N., Hancock, M. A., Massie, B., Siegel, P. and Brodt, P. A novel IGF-trap inhibits the growth of metastases from different tumor types. Gordon conference on Insulin-Like Growth Factors in Physiology & Disease, Ventura, CA, 2013.

Wang, N., Pinard, M., Lu, Y., Pilotte, A., Gilbert, R., Massie, B., and Brodt, P. Sustained production of a soluble IGF-I receptor by gutless adenovirus - transduced host cells protects from tumor growth in the liver. Proc. Am. Assoc. Cancer Res., 2013.

Qayum, N., Wang, N. and Brodt, P. Hepatic stellate cell activation is TNF receptor 2-dependent and required for angiogenesis and liver metstasis. Hallmarks of Cancer Cell Symposium, San Francisco, 2012.

Van den Eynden, G., Bird, N., Illemann, M., Eefsen, R.L., Brodt, P., Majeed, A.W., Høyer-Hansen, G. and Vermeulen, P.B. Identification and characterisation of histological growth patterns of liver metastases of colorectal cancer: the result of different tumor micro-environment interactions. Proc. Metastasis Res. Soc.- 2012.

Eefsen, R.L., Van den Eynden, G.G., Høyer-Hansen, G., Brodt, P., Laerum, O.D., Vermeulen, P.B., Christensen, I.J., Wettergren, A., Federspiel, B., Willemoe, G.L., Østerlind, K. and Illemann, M. Uniform growth pattern observed within chemonaïve patients with multiple liver metastases. Proc. Ketstone Symposium, Dublin, Ireland, 2012.

Ham, B., Auguste, P., Evrard, M., Wang, N., Lu, Y. and Brodt, P. TNF-receptor 2 plays a critical role in liver metastasis by regulating sinusoidal endothelial VCAM-1 expression, LY6G+ leukocyte recruitment and transendothelial migration. Proc. Am. Assoc. Cancer Res- 2012.

Eefsen, R.L., Van den Eynden, G.G., Brodt, P., Burnier, J., Høyer-Hansen, G., Ib Jarle, C., Metrakos, P., Laerum, O.D., Federspie, B., Willemoe, G., Østerlind, K. and Illemann, M. Growth patterns of liver metastases as compared to resected tumors of the same colorectal cancer patients. Proc. ASCO GI Symposium, San Francisco, 2012.

Wang, N., Pilotte, E., Mehdy, L., Lu, Y., Gilbert, R., Massie, B and Brodt, P. Developing an IGF–I receptor decoy as an anti-cancer drug. Proc. of the 5th China Medicinal Biotech Forum – 2011.

Seccarecia, E., Li, S. and Brodt, P. The role of IGF1 signaling in site-specific tumor metastasis: Regulating matrix metalloproteinase (MMP) expression. Proc. Am. Assoc. Cancer Res- 2011.

Wang, N., Spicer, J., Ferri, L. and Brodt, P. The TNF receptor 2 promotes liver metastasis by regulating the recruitment of host inflammatory cells. Proc. Am. Assoc. Cancer Res- 2011.

Wang, N., Spicer, J., Ferri, L. and Brodt, P. Distinct and gender-specific roles of the TNF receptors in liver metastasis. Proceedings of the 15th international meeting of the International Society for Cells of the Hepatic Sinusoids – 2010.

Li, S., Yang, L., Lin, R., Hiscott, J. and Brodt, P. Crosstalk between TNF-α-and IGF signalling increases IL-6 production and protects tumor cells from TNF-α-induced apoptosis in the liver. Proc. Am. Assoc. Cancer Res- 2010.

Li, S., Yang, L., Lin, R., Hiscott, J. and Brodt, P. Overexpression of the IGF-I receptor alters the metastatic properties of tumor cells by regulating of their cytokine profiles: role of NF-κB signaling. Proc. Am. Assoc. Cancer Res- 2009.

Burnier, J.V., Wang, N., Anteca, E., Michel, R.P., Hassanain, M., Metrakos, P., Burnier, M.N., Gallinger, S. and Brodt, P. Collagen IV expression levels are a critical determinant of liver metastasis. Proc. Am. Assoc. Cancer Res- 2009.

Books

Brodt, P. (Ed): Liver Metastasis: Biology and Clinical Management –Springer-Verlag Heidlberg, London, NY, 2011, ISBN: 978-94-007-0292-9.

Book Chapters

Spicer, J., Brodt, P. and Ferri, L. Role of inflammation in the early stages of liver metastasis. In: Liver metastasis: Biology and Clinical Management, Brodt P. (Ed), Springer, Heidelberg, London, NY, pp 155-186, 2011.

Li, S., Yakar, S. and Brodt, P. Role of the IGF- axis in liver metastasis: experimental and clinical evidence. In: Liver metastasis: Biology and Clinical Management, Brodt P. Editor, Springer Heidelberg, London, NY, pp. 233-272, 2011.

Burnier, J., Li, S. and Brodt, P. Role The role of the IGF Axis in human malignancy - Evidence from epidemiological studies and tissue analysis. In: Insulin Resistance and Cancer, Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications - Fantus G. (Ed). Springer NY- pp.213-242, 2011.

Brodt P. Role of the host inflammatory response in colon carcinoma initiation, progression and liver metastasis. In: Colon Cancer Liver Metastasis, Beauchemin N. and Huot J (Ed). Springer NY, pp. 289-319, 2010.