Photos

Hepatic stellate cells immunostained with antibodies to specific markers.

 

 

Tumor cells (green) and hepatic stellate cells (red) in a frozen liver section.

Hepatic stellate cells stained with antibodies to a specific marker.

Immunohistochemistry: the procedure

Optical live imaging of a nude mouse with liver metastases of aggressive human colon cancer cells tagged with a luciferase marker.

 

Immunohistochemistry image of a frozen liver section from mice bearing micrometastases of lung carcinoma cells (green). Shown are macrophages (red), pIGF-IR (white) and nuclei (blue).

Metastatic colon cancer cells (green) recruit host immune cells (red and yellow) to the liver.

Metastatic colon cancer cells (green) recruit host immune cells (red) to the liver.

The IGF- Trap: Novel therapy for metastatic malignancies (from Wang, N. et al, Molecular Cancer Therapeutics, 2015)

Myeloid derived suppressor cells (MDSC) in colon cancer liver metastases express TNFR2 (from Ham, B. et al, Cancer Research, 2015)

Regulatory T cells (Treg) infiltrate colon cancer liver metastases (from Ham, B. et al, Cancer Research, 2015)

MDSC in hepatic metastases of CRC patients express TNFR2 (from Ham, B. et al, Cancer Research, 2015)