• "Evolution of cell size control is canalized towards adders or sizers by cell cycle structure and selective pressures" Félix Proulx-Giraldeau, Jan M. Skotheim, Paul Francois. BiorXiv


  • "Universal antigen encoding of T cell activation from high-dimensional cytokine dynamics" Achar SR, Bourassa FXP, Rademaker TJ, Lee A, Kondo T, Salazar-Cavazos E, Davies JS, Taylor N, François P*, Altan-Bonnet G*, Science 2022. 376(6595):880-884
  • "Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock" Layague Sanchez PG, Mochulska V, Mauffette Denis C, Mönke G, Tomita T, Tsuchida-Straeten N, Petersen Y, Sonnen KF, François P*, Aulehla A* eLife (In Press)
  • "Latent space of a small genetic network: Geometry of dynamics and information" Seyboldt R, Lavoie J, Henry A, Vanaret J, Petkova MD, Gregor T, François P* PNAS.2022. 119 (26) e2113651119


  • "Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling" Bergeron-Sandoval LP, Kumar S, Khadivi Heris H, Chang CLA, Hendricks AG, Cornell CE, Keller SL, François P, Hendricks AG, Ehrlicher AJ, Pappu RV, Michnick SW*. PNAS. 2021. 118 (50) e2113789118
  • "Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential" Rogers D, Sood A, Wang H, van Beek JJP, Rademaker TJ, Artusa P, Schneider C, Shen C, Wong DC, Lebel M-E, Condotta SA, Richer MJ, Martins AJ, Tsang JS, Barreiro L, François P, Langlais D, Melichar HJ, Textor J, Mandl JN*. Cell Rep. 2021. 37(9):110064


  • "Geometric models for robust encoding of dynamical information into embryonic patterns" Jutras-Dubé L, El-Sherif E, François P, eLife 2020;9:e55778
  • "Numerical Parameter Space Compression and Its Application to Biophysical Models" Hsu CT, Brouhard GJ, François P, Biophys J 118(6):1455-1465


  • "Successive Kinesin-5 Microtubule Crosslinking and Sliding Promote Fast, Irreversible Formation of a Stereotyped Bipolar Spindle" " Leary A, Sim S, Nazarova E, Shulist K ,Genthial R, Yang SK ,Bui KH , Francois P , Vogel J Curr Biol. 29(22):3825-3837.e3
  • "Physical approaches to receptor sensing and ligand discrimination" François P, Zilman A, Curr. Op. Syst. Biol. 18,111-121
  • "A High-Throughput Image Correlation Method for Rapid Analysis of Fluorophore Photoblinking and Photobleaching Rates" Sehayek S, Gidi Y, Glembockyte V, Brandão HB, François P, Cosa G, Wiseman PW, ACS Nano 13, 10, 11955-11966
  • "Attack and Defense in Cellular decisions: lessons from machine learning" Rademaker T, Bengio E, François P, Physical Review X (In Press)
  • "In Silico Evolution of Biochemical Log-Response" Hemery M, François P, J. Phys. Chem. B, 123,10, 2235-2243


  • “φ-evo: A program to evolve phenotypic models of biological networks" Henry A, Hemery M, François P. PLoS Comput Biol 14(6): e1006244.
  • “Landscape, bifurcations, geometry for development" François P, Jutras-Dubé L. Curr. Op. Syst. Biol. (In Press)
  • “From evolutionary computation to phenotypic spandrels Inverse problem for immune ligand recognition" François P, Hemery M. Systems Immunology <
  • “Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation" Sonnen KF, Lauschke VM, Uraji J, Falk HJ, Petersen Y, Funk MC, Beaupeux M, François P, Merten CA, Aulehla A. Cell, 172(5):1079-1090


  • “Untangling the hairball: fitness based asymptotic reduction of biological networks" Proulx-Giraldeau F, Rademaker TJ, François P Biophys. J.,113(8):1893-1906 (2017) (see also a simple summary)
  • “Speed regulation of genetic cascades allows for evolvability in the body plan specification of insects" Zhua X, Rudolf H, Healey L, François P, Brown SJ, Klingler M, El-Sherif E, PNAS 114(41):E8646-E8655 (2017)
  • “Multiscale quantification of tissue behavior during amniote embryo axis elongation" Benazeraf B, Beaupeux M, Tchernookov M, Wallingford A, Salisbury T, Shirtz A, Shirtz A, Huss D, Pourquie O, François P, Lansford R, Development, 144: 4462-4472 (2017)
  • "Sorting at embryonic boundaries requires high heterotypic interfacial tension" Canty L, Zarour E, Kashkooli L, François P, Fagotto F Nature Communications, 8(1):157 (2017)






2010 and before

  •  “Adaptation d’échelle et gradient de phase dans un modèle ex vivo de somitogenèse”, François P. Med Sci (Paris).2013 Aug-Sep;29(8-9):696-8.
  •  “Une avancée technique pour comprendre la dynamique de l’ horloge de segmentation”, Delaune E, François P, Shih NP, Amacher SL. Med Sci (Paris). 2013 Apr;29(4):355-8.
  • “A non directional cell migration gradient in the presomitic mesoderm contributes to axis elongation in chicken embryos” Benazeraf B, François P, Baker R, Denans N, Little C, Pourquié O, Biologie Aujourd'hui 205(2):95-103. (2011) doi: 10.1051/jbio/2011014
  • Review on “A Cell Biologist’s Guide to Modeling and Bioinformatics”, François P,The Quaterly Review of Biology 83 (3):311-312(2008)
  • “ Genetic networks: design in silico and applications”, François P, Physicalia Magazine (journal of the Belgian Physical Society) (2005)
  • “Ces gaz qui soufflent le chaud”, François P, Science et vie hors série Énergie (2001)


Paul François

Ernest Rutherford Physics Building, Room 221
McGill University
3600 rue University
Montréal, QC, Canada H3A 2T8


Tel: +1 514 398 1635 Fax : +1 514 398 8434

Email: paulf at physics dot mcgill dot ca


Back to top