Adam Hendricks

Academic title(s): 

Assistant Professor
Department of Bioengineering

Associate Member
Department of Biomedical Engineering

Affiliate Member
Quantitative Biology Initiative 

Member
Integrated Program in Neuroscience

Adam Hendricks
Contact Information
Phone: 
514-398-8925
Address: 

Macdonald Engineering Building, Room 383
815 Sherbrooke St W
Montreal, Quebec H3A 0C3


Email address: 
adam.hendricks [at] mcgill.ca
Department: 
Bioengineering
Areas of expertise: 

Many essential cellular functions – cell division, motility, protein synthesis, intracellular transport, and others – are driven by motor proteins, a specialized set of enzymes that convert chemical energy into mechanical work. Two motor proteins, kinesin and cytoplasmic dynein, are responsible for the long-range transport of mRNA, proteins, organelles, and signaling molecules along the microtubule cytoskeleton. Active transport by kinesin and dynein is critical for the maintenance of biosynthetic, signaling, and degradative pathways in the cell. Long and highly-polarized cells like neurons are particularly sensitive, and accordingly mutations in kinesin or dynein cause neurodegenerative disease in mouse models and humans. Further, defects in intracellular transport have been linked to many neurodegenerative diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, and Huntington’s disease.

In the complex cellular environment, kinesin and dynein are regulated by interactions with the cytoskeleton, other motor proteins, and binding partners. These interactions allow motors to perform complicated functions such as cell division and the targeted trafficking of intracellular cargoes. The Hendricks lab is focused on understanding how motor proteins function collectively, and how interactions among motor proteins and with the complex cellular environment modulate their behavior. We employ in vitro experiments that incorporate aspects of the cellular environment, high-resolution tracking and manipulation in living cells, and mathematical modeling to understand motor protein dynamics in the cell. In particular, we aim to develop methods to extend the application of single molecule techniques such as optical trapping, FRET, and subpixel resolution tracking to examine motor function in living cells.

Research areas: 
Signals and Systems
Biomolecular and Cellular Engineering
Imaging and Microscopy
Area(s): 
Förster Resonance Energy Transfer (FRET) Microscopy
Cell Motor Function
Cell Manipulation
Mathematical Modeling
Motor Protein Dynamics
Optical Trapping
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