Khanh Huy Bui

Khanh Huy Bui
Department: 
Anatomy and Cell Biology
Contact Information
Email address: 
huy.bui [at] mcgill.ca
Address: 

Strathcona Anatomy Dentistry Building
3640 University, Room W309
Montreal, Quebec  H3A 0C7

Degree(s): 

BSc (University of New South Wales), MSc (Chalmers), PhD (Eidgenössische Technische Hochschule Zürich)

Position: 
Assistant Professor
Areas of interest: 

Structure, function, and assembly of the eukaryotic flagella.

Current research: 

Cilia are hair-like structures protruding out of the cell, taking part in a wide variety of biological processes. Since the cilia play an essential role in the development and function of the cell, cilia-related diseases usually have detrimental effects on the development and the health of patients such as retardation, blindness and chronic respiratory diseases. Understanding how cilia function, will provide opportunities to effectively diagnose and treat cilia-related diseases. Our research focuses on elucidating the three-dimensional structure of the cilia and the underlying logistic system used to dynamically maintain and assemble the cilia. We aim to obtain high resolutions of various components of the cilia by cryo-electron microscopy and cryo-electron tomography. Together with complementary data, we will model the atomic structures of cilia components to get novel insights into the molecular mechanism of ciliary assembly. In addition, we will also use correlative light and electron microscopy to explore the ciliary dynamics.

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