Craig A. Mandato

Craig A. Mandato
Department: 
Anatomy and Cell Biology
Contact Information
Email address: 
craig.mandato [at] mcgill.ca
Address: 

Strathcona Anatomy Building
3640 University, Room M/31 (Office), Room W211 (Lab)
Strathcona Anatomy Dentistry Building

Degree(s): 

PhD (Waterloo)

Position: 
Associate Professor, Department Chair
Areas of interest: 

The role of cytoskeletal components in cell division, cell motility and cellular wound healing.

Current research: 

The Mandato lab is interested in eukaryotic cells cytokinesis or fission. Aberrant cytokinesis results in aneuploidy, which is the leading cause of spontaneous miscarriages in humans and is the hallmark of many human cancers. During animal cell cytokinesis a contractile ring composed of actin filaments and myosin-2 is responsible for generating the force necessary for the fission event, while microtubules are responsible for directing the assembly of the contractile ring. The force needed for cellular locomotion is also generated by actin filaments and myosin-2 and is controlled by microtubules. Given the significance of these cellular functions to both normal and pathological human physiology, the goal of the Mandato lab is to understand the underlying cellular and molecular mechanisms. To address these issues methodologically, the Mandato lab uses cell biological and in vivo (frog) approaches.

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