“Although we used mice, the findings are extremely relevant to humans,” says senior author Dr. Gabriella Gobbi, a researcher of the Mental Illness and Addiction Axis at the RI-MUHC and an associate professor at the Faculty of Medicine at McGill University. “We used California mice which, like in some human populations, are monogamous and raise their offspring together.”
“Because we can control their environment, we can equalize factors that differ between them,” adds first author, Francis Bambico, a former student of Dr. Gobbi at McGill and now a post-doc at the Centre for Addiction and Mental Health (CAMH) in Toronto. “Mice studies in the laboratory may therefore be clearer to interpret than human ones, where it is impossible to control all the influences during development.”
Dr. Gobbi and her colleagues compared the social behaviour and brain anatomy of mice that had been raised with both parents to those that had been raised only by their mothers. Mice raised without a father had abnormal social interactions and were more aggressive than counterparts raised with both parents. These effects were stronger for female offspring than for their brothers. Females raised without fathers also had a greater sensitivity to the stimulant drug, amphetamine.
“The behavioural deficits we observed are consistent with human studies of children raised without a father,” says Dr. Gobbi, who is also a psychiatrist at the MUHC. “These children have been shown to have an increased risk for deviant behaviour and in particular, girls have been shown to be at risk for substance abuse. This suggests that these mice are a good model for understanding how these effects arise in humans.”
In pups deprived of fathers, Dr. Gobbi’s team also identified defects in the mouse prefrontal cortex, a part of the brain that helps control social and cognitive activity, which is linked to the behaviourial deficits.
“This is the first time research findings have shown that paternal deprivation during development affects the neurobiology of the offspring,” says Dr. Gobbi. These results should incite researchers to look more deeply into the role of fathers during critical stages of growth and suggest that both parents are important in children’s mental health development.
About the study
The paper in the journal Cerebral Cortex entitled Father absence in the monogamous California mouse impairs social behavior and modifies dopamine and glutamate synapses in the medial prefrontal cortex, was authored by Francis Bambico (First author) from the Behavioral Neurobiology Laboratory, Centre for Addiction and Mental Health (CAMH), Toronto; Baptiste Lacoste, Patrick Hattan and Gabriella Gobbi from the Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University Health Centre, Montreal. Cerebral Cortex is published by Oxford University Press.
This work was supported by the Fonds de la Recherche en Santé du Québec (FRSQ), and fellowships from the McGill University Health Centre (MUHC) and from the Faculty of Medicine of McGill University.
- Cited paper: cercor.oxfordjournals.org/
- McGill University Health Centre (MUHC): www.muhc.ca
- Research Institute of the MUHC: www.muhc.ca/research
- McGill University: www.mcgill.ca
- Fonds de recherche du Québec – Santé (FRQS) : www.frsq.gouv.qc.ca/en