Rosemary C. Bagot

Academic title(s): 

Assistant Professor
William Dawson Scholar

 

Contact Information:

 


Office: Stewart Biology Building, N8/4
Phone: 514.398.3419
Email: rosemary.bagot[at]mcgill.ca

 

Mailing Address:
Department of Psychology
1205 Dr Penfield Avenue
Montreal, QC
H3A 1B1

 

Biography: 

Research Areas:

Behavioral Neuroscience

Research Summary:

Dr. Bagot’s research focuses on the mechanisms of altered brain circuit function in depression. Epidemiological studies highlight the importance of stress in the etiology of depression. However, not all people who experience stress become depressed. Uncovering the brain circuit changes and behavioural characteristics associated with increased stress susceptibility is key to understanding differences in resilience and susceptibility to depression. Dr. Bagot’s research employs a multi-disciplinary approach integrating in vitro electrophysiology, in vivo optogenetics, in vivo calcium imaging and next-generation sequencing in robust mouse behavioural models to elucidate the brain circuit changes that drive maladaptive behaviours and the underlying gene expression networks that mediate altered circuit function.

Selected References:

Lorsch, Z.S., Loh, Y.E., Purushothaman, I., Walker, D.M., Parise, E.M., Salery, M., Cahill, M.E., Hodes, G.E., Pfau, M.L., Kronman, H., Hamilton, P.J., Issler, O., Labonte, B., Symonds, A.E., Zucker, M., Zhang, T.Y., Meaney, M.J., Russo, S.J., Shen, L., Bagot, R.C., & Nestler, E.J. (2018). Estrogen receptor a drives pro-resilient transcription in mouse models of depression. Nature Communications. 9(1): 1116.

Muir, J., Lorsch, Z.S., Ramakrishnan, C., Deisseroth, K., Nestler, E.J., Calipari, E.S., & Bagot, R.C. (2018). In vivo fiber photometry reveals signature of future stress susceptibility in nucleus accumbens. Neuropsychopharmacology. 43(2):255-263.
Peña, C.J., Kronman, H.G., Walker, D.M., Cates, H.M., Bagot, R.C., Purushothaman, I. Issler, O., Loh, Y.E., Leong, T., Kiraly, DD., Goodman, E., Neve, R.L., Shen, L., & Nestler, E.J. (2017). Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2. Science. 356(6343): 1185-1188.

Bagot, R.C., Cates, H.M., Purushothaman, I., Vialou, V., Heller, E.A., Yieh, L., LaBonté, B., Peña, C.J., Shen, L., Wittenberg, G.M. & Nestler, E.J. (2017). Ketamine and imipramine reverse transcriptional signatures of susceptibility and induce resilience-specific gene expression profiles. Biological Psychiatry. 81 (4): 285-295.
 
Bagot, R.C., Cates, H.M., Purushothaman, I., Lorsch, Z.L., Walker, D.M., Wang, J., Huang. X., Schlüter, O., Maze, S., Peña, C.J., Heller, E.A., Issler, O., Wang, M, Song, W., Stein, J.L., Liu, X.C., Doyle, M.A., Scobie, K.N., Sun, H.S., Neve, R.L., Geschwind, D., Dong, Y., Shen, L., Zhang, B., & Nestler, E.J. (2016) Circuit-wide transcriptional profiling reveals region-specific gene networks regulating depression susceptibility. Neuron. 90(5): 969-83

Calipari, E.S., Bagot, R.C., Purushothaman, I., Davidson, T.J., Yorgason, J.T., Peña, C.J., Walker, D.M., Pirpinias, S.T., Guise, K., Ramakrishnan, C., Deisseroth, K., & Nestler, E.J. (2016). In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward. Proceedings of the National Academy of Sciences.113(10): 2726-31.

Bagot, R.C., Parise, E.M., Peña, C.J., Zhang, H.X., Maze, I., Chaudhury, D.C. Persaud, B., Cachope, R., Bolaños, C.A., Cheer, J., Deisseroth, K., Han, M.H., & Nestler, E.J. (2015). Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression-like behavior. Nature Communications. 6: 7062.

Bagot, R.C., Tse, Y.C., Nguyen, H.B., Wong, A.S., Meaney, M.J., & Wong, T.P. (2012). Maternal care influences hippocampal N-methyl-D-aspartate receptor function and dynamic regulation by corticosterone in adulthood. Biological Psychiatry. 72(6), 491-8.