Rosemary C. Bagot
Office: Stewart Biology Building, N8/4
Department of Psychology
1205 Dr Penfield Avenue
Dr. Bagot’s research focuses on the mechanisms of altered brain circuit function in depression. Epidemiological studies highlight the importance of stress in the etiology of depression. However, not all people who experience stress become depressed. Uncovering the brain circuit changes and behavioural characteristics associated with increased stress susceptibility is key to understanding differences in resilience and susceptibility to depression. Dr. Bagot’s research employs a multi-disciplinary approach integrating in vitro electrophysiology, in vivo optogenetics, in vivo calcium imaging and next-generation sequencing in robust mouse behavioural models to elucidate the brain circuit changes that drive maladaptive behaviours and the underlying gene expression networks that mediate altered circuit function.
Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, et al. (2016): Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility. Neuron.
Bagot RC, Parise EM, Pena CJ, Zhang HX, Maze I, Chaudhury D, et al. (2015): Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nature communications. 6:7062.
Calipari ES, Bagot RC, Purushothaman I, Davidson TJ, Yorgason JT, Pena CJ, et al. (2016): In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward. Proceedings of the National Academy of Sciences of the United States of America. 113:2726-2731.
Bagot RC, Tse YC, Nguyen HB, Wong AS, Meaney MJ, Wong TP (2012): Maternal care influences hippocampal N-methyl-D-aspartate receptor function and dynamic regulation by corticosterone in adulthood. Biological psychiatry. 72:491-498.
Bagot RC, Zhang TY, Wen X, Nguyen TT, Nguyen HB, Diorio J, et al. (2012): Variations in postnatal maternal care and the epigenetic regulation of metabotropic glutamate receptor 1 expression and hippocampal function in the rat. Proceedings of the National Academy of Sciences of the United States of America. 109 Suppl 2:17200-17207.