Office: Stewart Biology Building, N8/5
Department of Psychology
1205 Dr Penfield Avenue
Our research group studies the neurobiology of memory, with a sharp focus on mechanisms involved in memory maintenance and forgetting. We investigate these phenomena from a systems perspective, using a variety of techniques and organisms; for example, we conduct behavioral studies in genetically modified Drosophila melanogaster, manipulate pharmacologically neurons in specific brain areas in rodents, and assess memory in humans using computer-based tasks. In collaborative projects, our group participates in studies exploring dysfunctions of memory processes in conditions such as Fragile X, autism, or Alzheimer’s disease.
Migues PV, Liu L, Archbold GEB, Einarsson EÖ, Wong J, Bonasia K, Ko SH, Wang YT, Hardt O (2016) Blocking Synaptic Removal of GluA2-Containing AMPA Receptors Prevents the Natural Forgetting of Long-Term Memories. The Journal of Neuroscience 36:3481–3494.
Hardt O, Nader K, Wang YT (2014) GluA2-dependent AMPA receptor endocytosis and the decay of early and late long-term potentiation: possible mechanisms for forgetting of short- and long-term memories. Philosophical Transactions of the Royal Society B: Biological Sciences 369:20130141.
Hardt O, Nader K, Nadel L (2013) Decay happens: the role of active forgetting in memory. Trends in Cognitive Sciences 17:111–120.
Nadel L, Hardt O (2011) Update on memory systems and processes. Neuropsychopharmacology 36:251–273.
Migues PV, Hardt O, Wu DC, Gamache K, Sacktor TC, Wang YT, Nader K (2010) PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nature Neuroscience 13:630–634.