Our lab has several ongoing projects which study novel cancer therapies and cancer prevention strategies. Our research program includes work in cellular and molecular biology, translational research, clinical studies, and epidemiology.
We examine the roles of peptide growth factors, particularly insulin and insulin-like growth factors (IGFs), in the pathophysiology of neoplasia. We have demonstrated that many cancers are dependent on IGF stimulation, and have shown that novel compounds that target IGF bioactivity deserve evaluation as cancer therapies.
We also are examining the mechanisms by which the well-known antidiabetic drug metformin may act to restrain cancer growth or prevent the development of cancer.
To view our detailed list of publications regarding our research, please consult the articles in our Publications or pollak-lab.oncology [at] mcgill.ca (email) our lab.