Recent Publications


  1. Haeger RM, Rassier DE. Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformitiesScientific Reports. 10(1):21590, 2020.
  2. Matusovsky OS, Kodera N, MacEachen C, Ando T, Cheng YS, Rassier DE. Millisecond Conformational Dynamics of Skeletal Myosin II Power Stroke Studied by High-Speed Atomic Force MicroscopyACS Nano. Published ahead, 2020.
  3. de Souza Leite F, Rassier DE. Sarcomere Length Nonuniformity and Force Regulation in Myofibrils and SarcomeresBiophysical Journal. 119(12):2372-2377, 2020.
  4. Haeger R, de Souza Leite F, Rassier DE. Sarcomere length non-uniformities dictate force production along the descending limb of the force-length relationProceedings of the Royal Society B. 287(1937):20202133, 2020.
  5. van de Locht M, de Winter JM, Rassier DE, Helmes MHB, Ottenheijm CAC. Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force TransducerJournal of Visualized Experiments. 159, 2020.
  6. Mendoza AC, Rassier DE. Extraction of Thick Filaments in Individual Sarcomeres Affects Force Production by Single MyofibrilsBiophysical Journal. 118(8):1921-1929, 2020.
  7. de Winter JM, Molenaar JP, Yuen M, van der Pijl R, Shen S, Conijn S, van de Locht M, Willigenburg M, Bogaards SJ, van Kleef ES, Lassche S, Persson M, Rassier DE, Sztal TE, Ruparelia AA, Oorschot V, Ramm G, Hall TE, Xiong Z, Johnson CN, Li F, Kiss B, Lozano-Vidal N, Boon RA, Marabita M, Nogara L, Blaauw B, Rodenburg RJ, Küsters B, Doorduin J, Beggs AH, Granzier H, Campbell K, Ma W, Irving T, Malfatti E, Romero NB, Bryson-Richardson RJ, van Engelen BG, Voermans NC, Ottenheijm CA. KBTBD13 is an actin-binding protein that modulates muscle kineticsJournal of Clinical Investigation. 130(2):754-767, 2020.
  8. Cheng YS, de Souza Leite F, Rassier DE. The load dependence and the force-velocity relation in intact myosin filaments from skeletal and smooth musclesAmerican Journal of Physiology-Cell Physiology. 318(1):C103-C110, 2020.
  9. Li A, Nelson SR, Rahmanseresht S, Braet F, Cornachione AS, Previs SB, O'Leary TS, McNamara JW, Rassier DE, Sadayappan S, Previs MJ, Warshaw DM. Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systemsProceedings of the National Academy of Sciences USA. 116(43):21882-21892, 2019.
  10. Persson M, Steinz MM, Westerblad H, Lanner JT, Rassier DE. Force generated by myosin cross-bridges is reduced in myofibrils exposed to ROS/RNSAmerican Journal of Physiology-Cell Physiology. 317(6):C1304-C1312, 2019.
  11. Matusovsky OS, Mansson A, Persson M, Cheng YS, Rassier DE. High-speed AFM reveals subsecond dynamics of cardiac thin filaments upon Ca 2+ activation and heavy meromyosin bindingProceedings of the National Academy of Sciences USA. 116(33):16384-16393, 2019.
  12. Liang F, Emeriaud G, Rassier DE, Shang D, Gusev E, Hussain SNA, Sage M, Crulli B, Fortin-Pellerin E, Praud JP, Petrof BJ. Mechanical ventilation causes diaphragm dysfunction in newborn lambsCritical Care. 23(1):123, 2019.
  13. Steinz MM, Persson M, Aresh B, Olsson K, Cheng AJ, Ahlstrand E, Lilja M, Lundberg TR, Rullman E, Möller KÄ, Sandor K, Ajeganova S, Yamada T, Beard N, Karlsson BC, Tavi P, Kenne E, Svensson CI, Rassier DE, Karlsson R, Friedman R, Gustafsson T, Lanner JT. Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritisJCI Insight. 5. pii: 126347, 2019.
  14. Bagni MA, Colombini B, Nocella M, Pregno C, S Cornachione A, Rassier DE. The effects of fatigue and oxidation on contractile function of intact muscle fibers and myofibrils isolated from the mouse diaphragmScientific reports. 9(1) 4422, 2019.
  15. Rassier DE, Kashina A. Protein arginylation of cytoskeletal proteins in the muscle: modifications modifying functionAmerican Journal of Physiology-Cell Physiology. 316(5):C668-C677, 2019.
  16. Månsson A, Persson M, Shalabi N, Rassier DE. Nonlinear Actomyosin Elasticity in Muscle? Biophysical Journal. 116 (2) 330-346, 2019.
  17. Cheng YS, Matusovskiy OS, Rassier DE. Cleavage of loops 1 and 2 in skeletal muscle heavy meromyosin (HMM) leads to a decreased functionArchives of Biochemistry and Biophysics. 661: 168-177, 2019.
  18. Lowey S, Bretton V, Joel PB, Trybus KM, Gulick J, Robbins J, Kalganov A, Cornachione AS, Rassier DE. Hypertrophic cardiomyopathy R403Q mutation in rabbit β-myosin reduces contractile function at the molecular and myofibrillar levels. Proceedings of the National Academy of Sciences (PNAS). 115(44):11238-11243, 2018.
  19. Rahman MA, Ušaj M, Rassier DE, Månsson A. Blebbistatin Effects Expose Hidden Secrets in the Force-Generating Cycle of Actin and MyosinBiophysical Journal. 115(2):386-397, 2018.
  20. Månsson A, Ušaj M, Moretto L, Rassier DE. Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle? International Journal of Molecular Sciences. 19(7). pii: E1863, 2018.
  21. Joureau B, de Winter JM, Conijn S, Bogaards SJP, Kovacevic I, Kalganov A, Persson M, Lindqvist J, Stienen GJM, Irving TC, Ma W, Yuen M, Clarke NF, Rassier DE, Malfatti E, Romero NB, Beggs AH, Ottenheijm CAC. Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3)Annals of Neurology. (2):269-282, 2018.
  22. de Souza Leite F, Minozzo FC, Altman D, Rassier DE. Microfluidic perfusion shows intersarcomere dynamics within single skeletal muscle myofibrilsProceedings of the National Academy of Sciences USA. 15;114(33):8794-8799, 2017.
  23. Kamandulis S, de Souza Leite F, Hernández A, Katz A, Brazaitis M, Bruton JD, Venckunas T, Masiulis N, Mickeviciene D, Eimantas N, Subocius A, Rassier DE, Skurvydas A, Ivarsson N, Westerblad H. Prolonged force depression after mechanically demanding contractions is largely independent of Ca 2+ and reactive oxygen species. FASEB Journal. 31(11):4809-4820, 2017.
  24. Rassier DE. Sarcomere mechanics in striated muscles: from molecules to sarcomeres to cells. American Journal of Physiology - Cell Physiology. 313(2):C134-C145, 2017.
  25. Shalabi N, Persson M, Månsson A, Vengallatore S, Rassier DE. Sarcomere Stiffness during Stretching and Shortening of Rigor Skeletal Myofibrils. Biophysical Journal. 113(12):2768-2776, 2017.
  26. Shalabi N, Cornachione A, Leite FS, Vengallatore S, Rassier DE. Residual force enhancement is regulated by titin in skeletal and cardiac myofibrils. The Journal of Physiology. 595(6):2085-2098, 2017. 
  27. Rassier DE. Reply to "Letter to the editor: Comments on Cornacchione et al. (2016): "The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms". American Journal of Physiology - Cell Physiology. 311(1):C160-161, 2016.
  28. Rassier DE, Minozzo FC. Length-dependent Ca2+ activation in skeletal muscle fibers from mammalians. American Journal of Physiology – Cell Physiology. 311(2):C201-C211, 2016.
  29. Leite FS, Kashina A, Rassier DE. Posttranslational Arginilation Regulates Striated Muscle Function. Exercise and Sport Sciences Reviews. 44(3):98-103, 2016.
  30. Rassier DE. Reply to "Letter to the editor: Titin-actin interaction: the report of its death was an exaggeration". American Journal of Physiology - Cell Physiology. 310(7):C623, 2016.
  31. Hussain SN, Cornachione AS, Guichon C, Al Khunaizi A, Leite FS, Petrof BJ, Mofarrahi M, Moroz N, de Varennes B, Goldberg P, Rassier DE. Prolonged controlled mechanical ventilation in humans triggers myofibrillar contractile dysfunction and myofilament protein loss in the diaphragm. Thorax. 71(5):436-45, 2016.
  32. Cheng AJ, Yamada T, Rassier DE, Andersson DC, Westerblad H, Lanner JT. Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery. Journal of Physiology (London). 594(18):5149-5160, 2016.
  33. Rassier DE. Two Kinases to Soften the Heart. Biophysical Journal.110 (2): 289-91, 2016.
  34. Power GA, Minozzo FC, Spendiff S, Filion M E, Konokhova Y, Purves-Smith MF, Pion C, Aubertin-Leheudre M, Morais JA, Herzog W, Hepple RT, Taivassalo T, Rassier DE. Reduction in single muscle fiber rate of force development with aging is not attenuated in world class older masters athletes. American Journal of Physiology - Cell Physiology . 310(4):C318-327, 2016.
  35. Leite FS, Minozzo FC, Kalganov A, Cornachione AS, Cheng YS, Leu NA, Han X, Saripalli C, Yates JR 3rd, Grazier H, Kashina AS, Rassier DE. Reduced passive force in skeletal muscles lacking protein arginylation. American Journal of Physiology - Cell Physiology. 310(2):C127-135, 2016.
  36. Cornachione, AS, Leite FS, Bagni, MA, Rassier, DE. The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms. American Journal of Physiology - Cell Physiology. 310(1):C19-C26, 2016.
  37. Minozzo FC, Altman A, Rassier DE. MgADP activation contributes to force enhancement during fast stretch of isolated skeletal myofibrils. Biochimical and Biophysical Research Communication. 463(4):1129-1134, 2015.
  38. Trecarten N, Minozzo FC, Leite FS, Rassier DE. Residual force depression in single sarcomeres is abolished by MgADP-induced activation. Scientific Reports. Article ID: 10555, 2015.
  39. Altman D, Minozzo F C, Rassier DE. Thixotropy and rheopexy of muscle fibers probed using sinusoidal oscillations. PLoS ONE. 10(4):e0121726, 2015.
  40. Philippou A, Minozzo FC, Spinazzola JM, Smith LR, Lei H, Rassier DE, Barton ER. Masticatory muscles of mouse do not undergo atrophy in space. The FASEB Journal. 29(7):2769-79, 2015.
  41. Rassier DE, Leite FS, Nocella M, Cornachione AS, Colombini B, Bagni MA. Non-crossbridge forces in activated striated muscles: a titin dependent mechanism of regulation? Journal of Muscle Research and Cell Motility. 36(1):37-45, 2015. 
  42. Månsson A, Rassier DE, Tsiavaliaris G. Poorly understood aspects of striated muscle contraction. BioMed Research International. Article ID 245154, 2015.
  43. Cornachione AS, Leite FS, Wang J, Leu NA, Kalganov A, Volgin D, Han X, Xu T, Cheng YS, Yates JR 3rd, Rassier DE, Kashina A. Arginylation of Myosin heavy chain regulates skeletal muscle strength. Cell Reports. 24:8(2):470-476, 2014.
  44. Yamada T, Fedotovskaya O, Cheng AJ, Cornachione AS, Minozzo FC, Aulin C, Friden C, Turesson C, Andersson DC, Glenmark B, Lundberg IE, Rassier DE, Westerblad H, Lanner JT. Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness. Annals of Rheumatic Diseases. 74(10):1907-1914, 2015.
  45. Minozzo FC, Baroni B, Correa JA, Vaz MA, Rassier DE. Force produced after stretch in sarcomeres and half-sarcomeres isolated from skeletal muscles. Scientific Reports. 3:2320, 2013.
  46. Minozzo FC, Rassier DE. The effects of Ca2+ and MgADP on force development during and after muscle length changes. PLoS ONE. 8(7):e68866. 2013. 
  47. Ribeiro PAB, Ribeiro JP, Minozzo FC, Pavlov I, Leu NA, Kurosaka S, Kashina A, Rassier DE. Contractility of myofibrils from the heart and diaphragm muscles measured with atomic force cantilevers: Effects of heart-specific deletion of arginyl-tRNA-protein transferase. International Journal of Cardiology. 168(4):3564-3571, 2013. 
  48. Kalganov A, Shalabi N, Zitouni N, Kachmar LH, Lauzon AM, Rassier DE. Forces measured with micro-fabricated cantilevers during actomyosin interactions produced by filaments containing different myosin isoforms and loop 1 structure. Biochimica et Biophysica Acta. 1830(3):2710-2719, 2013.
  49. Baroni BM, Rodrigues R, Franke RA, Geremia JM, Rassier DE, Vaz MA. Time course of neuromuscular adaptations to knee extensor eccentric training. International Journal of Sports Medicine. 34(10):904-11, 2013.
  50. Bates G, Sigurdardottir S, Kachmar L, Zitouni NB, Benedetti A, Petrof BJ, Rassier DE, Lauzon AM. Molecular, cellular, and muscle strip mechanics of the mdx mouse diaphragm. American Journal of Physiology - Cell Physiology. 304(9):C873-C880, 2013.
  51. Rassier DE. Residual force enhancement in skeletal muscles: one sarcomere after the other. Journal of Muscle Research and Cell Motility. 33(3-4):155-165, 2012.
  52. Kurosaka S, Leu NA, Pavlov I, Han X, Ribeiro PA, Xu T, Bunte R, Saha S, Wang J, Cornachione A, Mai W, Yates JR 3rd, Rassier DE, Kashina A. Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 53(3):333-341, 2012.
  53. Rassier DE. The mechanisms of the residual force enhancement after stretch of skeletal muscle: non-uniformity in half-sarcomeres and stiffness of titin. Proceedings of the Royal Society of London B. 279(1739):2705-2713, 2012.
  54. Minozzo FC, Hilbert L, Rassier DE. Pre-power-stroke cross-bridges contribute to force transients during imposed shortening in isolated muscle fibers. PLoS One. 7(1):e29356, 2012.
  55. Cornachione A, Rassier DE. A non-cross-bridge, static tension is present in permeabilized skeletal muscle fibers after active force inhibition or actin extraction. American Journal of Physiology – Cell Physiology. 302(3):C566-C574, 2012.
  56. Rassier DE, Pavlov I. Force produced by isolated sarcomeres and half-sarcomeres after an imposed stretch. American Journal of Physiology – Cell Physiology. 302(1):C240-C248, 2012.
  57. Labuda A, Brastaviceanu T, Pavlov I, Paul W, Rassier DE. Optical detection system for probing cantilever deflections parallel to a sample surface. The Review of Scientific Instruments. 82(1):013701, 2011.
  58. MacIntosh BR, Glumpak JJ, MacNaughton MB, Rassier DE. Pattern of summation with fatigue and inhibition of calcium release in rat muscle. Muscle & Nerve. 44(3), 410–417, 2011.
  59. Safronov AP, Shakhnovich M, Kalganov A, Kamalov IA, Shklyar TF, Blyakhman FA, Pollack GH. DC electric fields produce periodic bending of polyelectrolyte gels. Polymer. 52:2430-2436, 2011.
  60. Kalganov A, Novinger R, Rassier DE. A technique for simultaneous measurement of force and overlap between single muscle filaments of myosin and actin. Biochemical and Biophysical Research Communications. 403(3-4):351-356, 2010.
  61. Minozzo F, Rassier DE. Effects of blebbistatin and Ca2+ concentration on the force produced during stretch of skeletal muscle fibers. American Journal of Physiology – Cell Physiology. 299(5):C1127-1135, 2010.
  62. Pun C, Syed A, Rassier DE. History-dependent properties of skeletal muscle myofibrils contracting along the ascending limb of the force-length relationship. Proceedings of the Royal Society of London B. 277:475-484, 2010.
  63. Pavlov I, Novinger R, Rassier DE. Sarcomere dynamics in skeletal muscle myofibrils during isometric contractions. Journal of Biomechanics. 42(16):2808-2812, 2009.
  64. Pavlov I, Novinger R, Rassier DE. The mechanical behavior of individual sarcomeres and half-sarcomeres isolated from skeletal muscles. American Journal of Physiology – Cell Physiology. 297(5): C1211-C1219, 2009.
  65. Rassier DE. Molecular basis of force development by skeletal muscle during and after stretch. Molecular and Cellular Biomechanics. 6(4): 229-242, 2009.
  66. Rassier DE. Pre-power-stroke cross-bridges contribute to force during stretch of skeletal muscle myofibrils. Proceedings of the Royal Society of London B. 275: 2577–2586, 2008.
  67. MacIntosh BR, Smith MJ, Rassier DE. Staircase but not posttetanic potentiation in rat muscle after spinal cord hemisection. Muscle & Nerve. 38(5):1455-65, 2008.
  68. Joumaa V, Rassier DE, Leonard T, Herzog W.The origin of passive force enhancement in skeletal muscle. American Journal of Physiology – Cell Physiology. 294(1):C74-C78, 2008.
  69. MacIntosh BR, Jones D, Devrome AN, Rassier DE. Prediction of summation in incompletely fused tetanic contractions of rat muscle. Journal of Biomechanics. 40(5): 1066-1072, 2007.
  70. Joumaa V, Rassier DE, Leonard T, Herzog W. Passive force enhancement in single myofibrils. Pflügers Archiv - European Journal of Physiology. 455(2): 367-371, 2007.
  71. Bullimore SR, Leonard TR, Rassier DE, Herzog W. History-dependence of isometric muscle force: Effect of prior stretch or shortening amplitude. Journal of Biomechanics. 40(7): 1518-1524, 2007.
  72. Frasson VB, Rassier DE, Herzog W, Vaz MA. Dorsiflexor and plantarflexor torque-angle and torque-velocity relationships of classical ballet dancers and volleyball players. Br Journal of Biomechanics. 8(14):31-37, 2007.
  73. Herzog W, Lee EJ, Rassier DE. Residual force enhancement in skeletal muscle. Journal of Physiology (London). 574(3): 635-42, 2006.
Back to top