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Welcome to the Rassier Laboratory

Department of Kinesiology and Physical Education | Montreal, Quebec

 

 

Our Research:

Our laboratory focuses on the molecular and cellular mechanisms of muscle contraction and force regulation in health and disease.

The laboratory studies muscle contraction on different scales such as single cells, myofibrils, sarcomeres, filaments, and motor proteins. The laboratory also designs and develops research instruments and experimental systems that are unique.

We use advanced microscopy and micro/nano fabrication technologies to measure muscle forces ranging from millinewtons to piconewtons.

Recent Papers:

Matusovsky O. S., Kodera N., MacEachen C., Ando T., Cheng Y. S., Rassier D. EMillisecond Conformational Dynamics of Skeletal Myosin II Power Stroke Studied by High-Speed Atomic Force MicroscopyACS Nano. 15(2):2229-2239, 2021. 

Haeger R. M., Rassier D. EForce enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformitiesScientific Reports. 10(1):21590, 2020.   

Cheng Y. S, de Souza Leite F., Rassier D. EThe load dependence and the force-velocity relation in intact myosin filaments from skeletal and smooth musclesAmerican Journal of Physiology-Cell Physiology. 318(1):C103-C110, 2020. 

Matusovsky O. S., Mansson A., Persson M., Cheng Y. S., Rassier D. EHigh-speed AFM reveals subsecond dynamics of cardiac thin filaments upon Ca 2+ activation and heavy meromyosin bindingProceedings of the National Academy of Sciences USA. 116(33):16384-16393, 2019.    

 de Souza Leite F., Minozzo F. C., Altman D., Rassier D. EMicrofluidic perfusion shows intersarcomere dynamics within single skeletal muscle myofibrilsProceedings of the National Academy of Sciences USA. 15;114(33):8794-8799, 2017.                                                                                                                                            

 

 

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