Welcome to the Rassier Laboratory
Department of Kinesiology and Physical Education | Montreal, Quebec
Our laboratory focuses on the molecular and cellular mechanisms of muscle contraction and force regulation in health and disease.
The laboratory studies muscle contraction on different scales such as single cells, myofibrils, sarcomeres, filaments, and motor proteins. The laboratory also designs and develops research instruments and experimental systems that are unique.
We use advanced microscopy and micro/nano fabrication technologies to measure muscle forces ranging from millinewtons to piconewtons.
Matusovsky O. S., Kodera N., MacEachen C., Ando T., Cheng Y. S., Rassier D. E. Millisecond Conformational Dynamics of Skeletal Myosin II Power Stroke Studied by High-Speed Atomic Force Microscopy. ACS Nano. 15(2):2229-2239, 2021.
Haeger R. M., Rassier D. E. Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities. Scientific Reports. 10(1):21590, 2020.
Cheng Y. S, de Souza Leite F., Rassier D. E. The load dependence and the force-velocity relation in intact myosin filaments from skeletal and smooth muscles. American Journal of Physiology-Cell Physiology. 318(1):C103-C110, 2020.
Matusovsky O. S., Mansson A., Persson M., Cheng Y. S., Rassier D. E. High-speed AFM reveals subsecond dynamics of cardiac thin filaments upon Ca 2+ activation and heavy meromyosin binding. Proceedings of the National Academy of Sciences USA. 116(33):16384-16393, 2019.
de Souza Leite F., Minozzo F. C., Altman D., Rassier D. E. Microfluidic perfusion shows intersarcomere dynamics within single skeletal muscle myofibrils. Proceedings of the National Academy of Sciences USA. 15;114(33):8794-8799, 2017.