Currie gymnasium


Welcome to the Rassier Laboratory

Department of Kinesiology and Physical Education | Montreal, Quebec



Our Research:

Our laboratory is dedicated to investigating the underlying molecular and cellular mechanisms of muscle contraction and force regulation in both healthy and diseased states. Our research encompasses a wide range of scales, including single cells, myofibrils, sarcomeres, filaments, and motor proteins. To achieve this, we utilize cutting-edge microscopy and micro/nano fabrication technologies to accurately measure muscle forces ranging from millinewtons to piconewtons. Additionally, the laboratory is also involved in designing and developing unique research instruments and experimental systems, tailored to fit our specific research needs.

Recent Papers:

Moretto L., Ušaj M., Matusovsky O., Rassier D. E., Friedman R., Månsson A. Multistep orthophosphate release tunes actomyosin energy transduction. Nature Communication. 13(1):4575, 2022.

Matusovsky O. S., Kodera N., MacEachen C., Ando T., Cheng Y. S., Rassier D. EMillisecond Conformational Dynamics of Skeletal Myosin II Power Stroke Studied by High-Speed Atomic Force MicroscopyACS Nano. 15(2):2229-2239, 2021. 

Haeger R. M., Rassier D. EForce enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformitiesScientific Reports. 10(1):21590, 2020.   

Cheng Y. S., de Souza Leite F., Rassier D. EThe load dependence and the force-velocity relation in intact myosin filaments from skeletal and smooth musclesAmerican Journal of Physiology-Cell Physiology. 318(1):C103-C110, 2020. 

Matusovsky O. S., Mansson A., Persson M., Cheng Y. S., Rassier D. EHigh-speed AFM reveals subsecond dynamics of cardiac thin filaments upon Ca 2+ activation and heavy meromyosin bindingProceedings of the National Academy of Sciences USA. 116(33):16384-16393, 2019.    

 de Souza Leite F., Minozzo F. C., Altman D., Rassier D. EMicrofluidic perfusion shows intersarcomere dynamics within single skeletal muscle myofibrilsProceedings of the National Academy of Sciences USA. 15;114(33):8794-8799, 2017.                                                                                                                                            



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