Unconventional NMDA Receptor Signalling in Neocortical Plasticity

Tuesday, January 28, 2020 12:00to13:00
Montreal Neurological Institute deGrandpre Communications Centre, 3801 rue University, Montreal, QC, H3A 2B4, CA, 3801 rue University, Montreal, QC, H3A 2B4, CA
Free Admission

McGill's Seminar Series in Quantitative Life Sciences and Medicine
Sponsored by CAMBAM, QLS, MiCM and the Ludmer Centre

Title: Unconventional NMDA Receptor Signalling in Neocortical Plasticity
Speaker: Jesper Sjostrom, McGill University
When: Tuesday, January 28, 12-1pm 
Where: Montreal Neurological Institute, deGrandpre Communications Centre

Abstract: In the classical view, postsynaptic NMDA receptors (NMDARs) trigger Hebbian plasticity via calcium influx. However, unconventional presynaptic NMDARs (preNMDARs) which regulate both long-term and short-term plasticity at several synapse types have also been found. A lack of sufficiently specific experimental manipulations and a poor understanding of how preNMDARs signal have contributed to long-standing controversy surrounding these receptors. Our recent work indicates that, whereas ionotropic preNMDARs signaling controls evoked release, spontaneous release is regulated by metabotropic NMDAR signaling. Elucidating unconventional NMDAR signaling modes — both presynaptically and metabotropically — is in other words key to a full understanding of NMDAR function in health as well as disease.

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