Date: Friday, December 1 | Time: 12 pm (EST) | Location: Virtual (Zoom) | Free
Join via Zoom: https://mcgill.ca/x/Uby
It is a challenge to deposit nanofibres into hierarchically ordered and graded materials that are representative (morphologically and mechanically) of target tissues, and enable stimulation and repair. Solution blow spinning has emerged as a disruptive nanofibre spinning technology that enables the rapid deposition of fibres and does not require the use of electric fields. Stimulatory fibres can be produced from materials that are electrically conductive - under investigation for peripheral nerve tissue regeneration, piezoelectric materials, as well as bioactive glasses/hybrids for therapeutic ion delivery.
Fibre spinning is combined with automated collection devices to enable the deposition of aligned fibres with specific orientations (e.g. mimicking the +/- fibre angle arrangements observed in blood vessels). Acellular or cell-laden hydrogel layers can be intercalated between reinforcing fibre layers to build up multi-layer hierarchical constructs (e.g. tubes).
It is a further challenge to replicate some of the biochemical patterns indicative of natural extracellular matrix (ECM) signalling that occurs through gradients and spatial localization. To address this we apply photo-click chemistry to tether bioactive moieties to nanofibre structures. This system can serve as a basis for testing cell response to tethered signalling sites and other stimuli at the fibre/fibre-mat level.
Dr. Jonny Blaker
Dr. Jonny Blaker is Research Area Lead for Biomedical Materials at the Henry Royce Institute, the UK’s national institute for advanced materials , and Senior Lecturer in Biomaterials at The University of Manchester . He is also Adjunct Professor at The University of Oslo, Department of Biomaterials. Prior to joining The University of Manchester as Lecturer in 2014 he was Research Fellow in the Department of Chemical Engineering, Imperial College London, in the Polymer Composites and Engineering (PaCE) group working with Professor Alexander Bismarck developing bioinspired hierarchical composites, sustainable biobased composites, and bioactive composites for medical use.
He obtained his PhD in 2007 from the Department of Materials, Imperial College London under the supervision of Professor Aldo Boccaccini. He has a professional background as a Design Engineer, Dyson Ltd. He established his Bioactive Materials Group in 2014. Principal research areas are i) hierarchical composite materials and fibres as scaffolds for regenerative medicine, and ii) advanced materials derived from synthetic biology/2D nanocomposite materials