Consequences of exposure to organophosphate esters found in the Canadian environment on male and female reproductive health

Our research focuses on a major group of chemicals derived from consumer products, the organophosphate esters (OPEs), that is in rapidly increasing use. We are testing the hypothesis that exposure to these compounds is associated with adverse effects on the male and/or female reproductive systems. We are using cells with key endocrine functions to identify genes and pathways that are disrupted by OPEs and may serve as biomarkers of their effects on fertility. Using an animal model we are elucidating the effects of exposure to the mixture of OPEs found in Canadian house dust on male and female fertility. Finally, we are assessing the association of human OPE body burden with female and male infertility. These studies are enhancing our understanding of the health consequences of exposure to a family of widely used chemicals for which we currently have very limited data. In addition, we expect that they will contribute to the development of policies to ensure the identification of alternative chemicals that are safer and have a reduced environmental impact prior to their use as replacements.

Barbara Hales (PI), Cindy Goodyer and Bernard Robaire (Co-PIs)

This research project is supported by:
the Institute of Human Development, Child and Youth Health - CIHR