Dr. Eric Grignano
Assistant Professor, Department of Medicine, Division of Hematology
My research program focuses on iron metabolism, ferritinophagy, and ferroptosis in myeloid malignancies, with a particular emphasis on acute myeloid leukemia and clonal hematopoiesis. I develop translational strategies combining functional genomics, metabolic profiling, and therapeutic targeting to identify novel vulnerabilities in leukemia stem and progenitor cells. The long-term goal is to translate iron-handling dependencies into actionable therapeutic approaches.
1.Targeting ferritinophagy and NCOA4-dependent iron recycling in acute myeloid leukemia stem and progenitor cells using CRISPR and pharmacologic approaches.
2.Iron metabolism and mitochondrial ROS signaling as therapeutic vulnerabilities in therapy-resistant myeloid malignancies.
3.Functional profiling of ferroptosis sensitivity across genetically defined AML subtypes and combination strategies with targeted therapies (e.g., BCL2 inhibition).