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2014


February 2014

Recent discoveries from the Chen lab were recently highlighted in a short animation by SimpliSci. Please see: 

http://www.youtube.com/watch?v=4mPeV1Kuq6A

The CRN congratulates Dr. Tiago Ferreira and members of the van Meyel Laboratory for their recent publication in Development. The manuscript was highlighted on the cover of the journal. 

See Ferreira T, Ou Y, Li S, Giniger E, van Meyel DJ. Dendrite architecture organized by transcriptional control of the F-actin nucleator Spire. Development. 2014 Feb;141(3):650-60.

CRN Publications

Ferreira T, Ou Y, Li S, Giniger E, van Meyel DJ. Dendrite architecture organized by transcriptional control of the F-actin nucleator Spire. Development. 2014 Feb;141(3):650-60.

Carbonetto S. A blueprint for research on Shankopathies: A view from research on autism spectrum disorder. Dev Neurobiol. 2014 Feb;74(2):85-112.

Cook D, Nuro E, Murai KK. Increasing our understanding of human cognition through the study of Fragile X Syndrome. Dev Neurobiol. 2014 Feb;74(2):147-77.

January 2014

CRN Publications

Costa RP, Watt AJ, Sjöström PJ. How to train a neuron. Elife. 2013;2:e00491.

Kays I, Cvetkovska V, Chen BE. Structural and functional analysis of single neurons to correlate synaptic connectivity with grooming behavior. Nat Protoc. 2014 Jan;9(1):1-10. 

2013


December 2013

CRN Publications

Blackman AV, Abrahamsson T, Costa RP, Lalanne T, Sjöström PJ. Target-cell-specific short-term plasticity in local circuits. Front Synaptic Neurosci. 2013 Dec 6;5:11. eCollection 2013. 

October 2013

CRN Publications

Cameron S, Chang WT, Chen Y, Zhou Y, Taran S, Rao Y. Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein Borderless. J Neurosci. 2013 Oct 30;33(44):17413-21.

Goldman JS, Ashour MA, Magdesian MH, Tritsch NX, Harris SN, Christofi N, Chemali R, Stern YE, Thompson-Steckel G, Gris P, Glasgow SD, Grutter P, Bouchard JF, Ruthazer ES, Stellwagen D, Kennedy TE.

Pribiag H, Stellwagen D. Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly. J Neurosci. 2013 Oct 30;33(44):17278-89. 

Robins SC, Trudel E, Rotondi O, Liu X, Djogo T, Kryzskaya D, Bourque CW, Kokoeva MV. Evidence for NG2-glia derived, adult-born functional neurons in the hypothalamus. PLoS One. 2013 Oct 29;8(10):e78236.

Sudbury JR, Bourque CW. Dynamic and permissive roles of TRPV1 and TRPV4 channels for thermosensation in mouse supraoptic magnocellular neurosecretory neurons. J Neurosci. 2013 Oct 23;33(43):17160-5.

July 2013

Congratulations to Dr. Jesper Sjöström for receiving a 5 year New Investigator Salary Award from the Canadian Institutes of Health Research.

Congratulations to Dr. David Stellwagen for receiving a two year grant from the ALS Society of Canada, ALS Canada Research Fund grant entitled, "The role of TNFalpha in neurodegeneration."

Congratulations to Dr. Keith Murai for receiving a two year grant from the Pfizer/Fonds de recherche du Québec - Santé Innovation Fund entitled, "Investigation des interactions de la microglie-astrocyte dans la maladie d’Alzheimer."

CRN Publications

Altimimi HF, Stellwagen D. Persistent synaptic scaling independent of AMPA receptor subunit composition. J Neurosci. 2013 Jul 17;33(29):11763-7.

Siddoway BA, Altimimi HF, Hou H, Petralia RS, Xu B, Stellwagen D, Xia H. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci. 2013 Jul 3;33(27):11206-11. doi: 10.1523/JNEUROSCI.5241-12.2013.

June 2013

CRN Publications

Costa RP, Sjöström PJ, van Rossum MC. Probabilistic inference of short-term synaptic plasticity in neocortical microcircuits. Front Comput Neurosci. 2013 Jun 6;7:75. doi: 10.3389/fncom.2013.00075.

Pribiag H, Stellwagen D. TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors. J Neurosci. 2013 Oct 2;33(40):15879-93. 

Ricoult SG, Goldman JS, Stellwagen D, Juncker D, Kennedy TE. Generation of microisland cultures using microcontact printing to pattern protein substrates. J Neurosci Methods. 2012 Jun 30;208(1):10-7. doi: 10.1016/j.jneumeth.2012.04.016.

May 2013

The CRN congratulates Vedrana Cvetkovska, Alexa Hibbert, and Dr. Farida Emran in the laboratory of Dr. Brian Chen for their recent publication in Nature Neuroscience entitled Overexpression of Down Syndrome Cell Adhesion Molecule Impairs Precise Synaptic Targeting. Details about the research can be found at: http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3396.html

CRN Publications

Cvetkovska V, Hibbert AD, Emran F, Chen BE. Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting. Nat Neurosci. 2013 Jun;16(6):677-82. doi: 10.1038/nn.3396. Epub 2013 May 12.

Peng H, Ong YM, Shah WA, Holland PC, Carbonetto S. Integrins regulate centrosome integrity and astrocyte polarization following a wound. Dev Neurobiol. 2013 May;73(5):333-53. doi: 10.1002/dneu.22055.

April 2013

The CRN congratulates Dr. Charles Bourque who was recently awarded the 2013 Joseph Erlanger Distinguished Lectureship by the Central Nervous System Section of the American Physiological Society. Information about the announcement can be found at: http://www.newswise.com/articles/american-physiological-society-announces-top-award-lectures-distinguished-lectureships-at-experimental-biology-2013

February 2013

The CRN congratulates Ms. Katrina Choe in the lab of Charles Bourque for being chosen as a recipient of the Faculty of Medicine's McGill MedStar Award in recognition of her publication entitled “Taurine Release by Astrocytes Modulates Osmosensitive Glycine Receptor Tone and Excitability in the Adult Supraoptic Nucleus." J. Neurosci. 2012 32:12518-27.

CRN Publications

Suzuki-Anekoji M, Suzuki A, Wu SW, Angata K, Murai KK, Sugihara K, Akama TO, Khoo KH, Nakayama J, Fukuda MN, Fukuda M. In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. J Biol Chem. 2013 Feb 15;288(7):5007-16. 

January 2013

Congratulations to Dr. Jesper Sjöström for receiving a 5 year CIHR Operating Grant entitled: Presynaptic NMDA receptors in neocortical plasticity.

CRN Publications

Costa RP, Watt AJ, Sjöström PJ. How to train a neuron. elife. 2013;2:e00491. doi: 10.7554/eLife.00491. Epub 2013 Jan 22.

Fasano C, Bourque MJ, Lapointe G, Leo D, Thibault D, Haber M, Kortleven C, Desgroseillers L, Murai KK, Trudeau LÉ. Dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both D1 and D2 dopamine receptors. Neuropharmacology. 2013 Apr;67:432-43. doi: 10.1016/j.neuropharm.2012.11.030. Epub 2012 Dec 8.

Horn KE, Glasgow SD, Gobert D, Bull SJ, Luk T, Girgis J, Tremblay ME, McEachern D, Bouchard JF, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, Chapman CA, Ruthazer ES, Kennedy TE. DCC Expression by Neurons Regulates Synaptic Plasticity in the Adult Brain. Cell Rep. 2013 Jan 31;3(1):173-85. 



2012


December 2012

CRN Publications

David S, Zarruk JG, Ghasemlou N. Inflammatory pathways in spinal cord injury. Int Rev Neurobiol. 2012;106:127-52. doi: 10.1016/B978-0-12-407178-0.00006-5.

David S, López-Vales R, Wee Yong V. Harmful and beneficial effects of inflammation after spinal cord injury: potential therapeutic implications. Handb Clin Neurol. 2012;109:485-502. doi: 10.1016/B978-0-444-52137-8.00030-9.

October 2012

The CRN congratulates Dr. Brian Chen for receiving a Young Investigator Award from the Brain and Behavior Research Foundation (formerly NARSAD Foundation). The title of the award is: The role of the Plexin receptors in neural circuit formation and function.

Congratulations to Dr. Brian Chen  for receiving a 5 year NSERC Discovery Grant entitled: Synaptic Targeting in Hard-Wired Neural Circuits Underlying an Innate Behavior.

CRN Publications

Zhou Y, Cameron S, Chang WT, Rao YControl of directional change after mechanical stimulation in Drosophila. Mol Brain. 2012 Oct 29;5:39. doi: 10.1186/1756-6606-5-39.

September 2012

CRN Publications

Peng H, Ong YM, Shah WA, Holland PC, Carbonetto S. Integrins regulate centrosome integrity and astrocyte polarization following a wound. Dev Neurobiol. 2012 Sep 4. doi: 10.1002/dneu.22055. [Epub ahead of print]

August 2012

The CRN congratulates Katrina Choe and Dr. Charles Bourqe for their recent publication in the Journal of Neuroscience entitled Taurine release by astrocytes modulates osmosensitive glycine receptor tone and excitability in the adult supraoptic nucleus. The article was featured on the cover of the journal. 

Congratulations to Dr. Don van Meyel for receving a 5 year NSERC Discovery grant entitled: Using Drosophila to investigate the roles of conserved IgSF proteins in neuronal differentiation and axon guidance.

CRN Publications

Buchanan KA, Blackman AV, Moreau AW, Elgar D, Costa RP, Lalanne T, Tudor Jones AA, Oyrer J, & Sjöström PJ: Target-specific expression of presynaptic NMDA receptors in neocortical microcircuits. Neuron 2012 75:451-466.

Choe KY, Olson JE, Bourque CW. Taurine release by astrocytes modulates osmosensitive glycine receptor tone and excitability in the adult supraoptic nucleus. J. Neurosci. 2012 32:12518-27.

Markram H, Gerstner W, & Sjöström PJ (Eds): Spike-timing-dependent plasticity: a comprehensive overview. Frontiers Research Topic eBook 2012 ISBN: 978-2-88919-043-0, Frontiers Media SA.

Zusso M, Methot L, Lo R, Greenhalgh AD, David S, Stifani S. Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor runx1. J Neurosci. 2012 32:11285-98.

July 2012

CRN Publications

Berard JL, Zarruk JG, Arbour N, Prat A, Yong VW, Jacques FH, Akira S, David S. Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis. Glia. 2012 60:1145-59. 

Chierzi S, Stachniak TJ, Trudel E, Bourque CW, Murai KK. Activity maintains structural plasticity of mossy fiber terminals in the hippocampus. Mol Cell Neurosci. 2012 50:260-71. 

David S, Greenhalgh AD, López-Vales R. Role of phospholipase A2s and lipid mediators in secondary damage after spinal cord injury. Cell Tissue Res. 2012 349:249-67. 

Verbich D, Prenosil GA, Chang PK, Murai KK, McKinney RA. Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus. Glia. 2012 60:1067-77. 

June 2012

Congratulations to Dr. Keith Murai for receving a 5 year CIHR operating grant entitled: Neuron-glial mechanims in neural circuitry plasticity and homeostasis.

CRN Publications

Ricoult SG, Goldman JS, Stellwagen D, Juncker D, Kennedy TE. Generation of microisland cultures using microcontact printing to pattern protein substrates. J Neurosci Methods. 2012 208:10-7. 

May 2012

CRN Publications

Rathore KI, Redensek A, David S. Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-α and TGF-β1. Glia. 2012 60:738-50. 

Stochmanski SJ, Therrien M, Laganière J, Rochefort D, Laurent S, Karemera L, Gaudet R, Vyboh K, Van Meyel DJ, Di Cristo G, Dion PA, Gaspar C, Rouleau GA. Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models. Hum Mol Genet. 2012 21:2211-8. 

April 2012

CRN Publications

Bourque CW, Guilak F, Liedtke W. A TRP that makes us feel hyper. J Physiol. 2012 590:1779-80.

Schulz K, Kroner A, David S. Iron efflux from astrocytes plays a role in remyelination. J Neurosci. 2012 32:4841-7.

Trudel E, Bourque CW.  Circadian modulation of osmoregulated firing in rat supraoptic nucleus neurones. J Neuroendocrinol. 2012 24:577-86.

March 2012

CRN Publications

Zhou L, Jones EV, Murai KK. EphA signaling promotes actin-based dendritic spine remodeling through slingshot phosphatase. J Biol Chem. 2012 287:9346-59. 

February 2012

CRN Publications

Jones EV, Cook D, Murai KK. A neuron-astrocyte co-culture system to investigate astrocyte-secreted factors in mouse neuronal development. Methods Mol Biol. 2012;814:341-52.

Peng H, Carbonetto S. Astrocyte polarization and wound healing in culture: studying cell adhesion molecules. Methods Mol Biol. 2012;814:177-88.

Rathore KI, Redensek A, David S. Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-α and TGF-β1. Glia. 2012 Feb 1 (Epub ahead of print)

Trudel E, Bourque CW. Circadian modulation of osmoregulated firing in rat supraoptic nucleus neurons. J Neuroendocrinol. 2012 Feb 14 (Epub ahead of print)

January 2012

Congratulations to Dr. Brian Chen for receiving a 5 year grant from CIHR entitled: Molecular and Cellular Mechanisms of Neural Circuit Formation.

Congratulations to Dr. Charles Bourque for receiving a 5 year grant from CIHR entitled: Role of TRPV channels in the thermal and osmotic control of vasopressin neurons.

The CRN congratulates Dr. Jesper Sjöström for being appointed as Chief Editor for Frontiers in Synaptic Neuroscience. 

Congratulations to Dr. Keith Murai for being appointed Associate Editor at The Journal of Neuroscience.


2011

December 2011

CRN Publications

López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, Baskakis C, Rathore KI, Constantinou-Kokotou V, Stephens D, Shimizu T, Dennis EA, Kokotos G, David S. Phospholipase A2 superfamily members play divergent roles after spinal cord injury. FASEB J. 2011 Dec;25(12):4240-52. 

November 2011

CRN Publications

Bouhy D, Ghasemlou N, Lively S, Redensek A, Rathore KI, Schlichter LC, David S. Inhibition of the Ca²⁺-dependent K⁺ channel, KCNN4/KCa3.1, improves tissue protection and locomotor recovery after spinal cord injury. J Neurosci. 2011 Nov 9;31(45):16298-308.

Murai KK, Pasquale EB. Eph receptors and ephrins in neuron-astrocyte communication at synapses. Glia. 2011 Nov;59(11):1567-78. 

October 2011

CRN Publications

Ciura S, Liedtke W, Bourque CW. Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. J Neurosci. 2011 Oct 12;31(41):14669-76.

Cook D, Sanchez-Carbente Mdel R, Lachance C, Radzioch D, Tremblay S, Khandjian EW, DesGroseillers L,Murai KK. Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. PLoS One. 2011;6(10):e26120. 

September 2011

CRN Publications

Costa RP, Sjöström PJ. One cell to rule them all, and in the dendrites bind them. Front Synaptic Neurosci. 2011;3:5. 

Panatier A, Vallée J, Haber M, Murai KK, Lacaille JC, Robitaille R. Astrocytes are endogenous regulators of basal transmission at central synapses. Cell. 2011 Sep 2;146(5):785-98.

Rathore KI, Berard JL, Redensek A, Chierzi S, Lopez-Vales R, Santos M, Akira S, David S. Lipocalin 2 plays an immunomodulatory role and has detrimental effects after spinal cord injury. J Neurosci. 2011 Sep 21;31(38):13412-9.

Schulz K, Vulpe CD, Harris LZ, David S. Iron efflux from oligodendrocytes is differentially regulated in gray and white matter. J Neurosci. 2011 Sep 14;31(37):13301-11.

August 2011

CRN Publications

Markram H, Gerstner W, Sjöström PJ. A history of spike-timing-dependent plasticity. Front Synaptic Neurosci. 2011;3:4.

June 2011

Congratulations to Drs. Antje Kroner and Sam David for publishing "Repertoire of microglial and macrophage responses after spinal cord injury" in Nature Reviews in Neuroscience in June (see CRN Headlines for more details on this publication).

Congratulations to Dr. Yann Bernardinelli, Chris Salmon, Dr. Emma Jones, Dr. Todd Farmer, Dr. David Stellwagen, and Dr. Keith Murai for having their publication "Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus" featured in the June 15th issue of the Journal of Neuroscience and for having an image selected for the cover photo.

CRN Publications

Bernardinelli Y, Salmon C, Jones EV, Farmer WT, Stellwagen D, Murai KK. Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus. J Neurosci. 2011 Jun 15;31(24):8905-19

David S, Kroner A. Repertoire of microglial and macrophage responses after spinal cord injury. Nat Rev Neurosci. 2011 Jun 15;12(7):388-99.

May 2011

The CRN would like express our deepest sympathy to the family, friends and colleagues of Dr. David Colman, Director of the Montreal Neurological Institute, who passed away June 1, 2011. For those of us who had the pleasure to know him, Dr. Colman will be greatly missed for his dedication, good humor and important contributions to our neuroscience community.

April 2011

CRN Publications

Fernandes C, Rao Y. Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila. Mol Brain. 2011 Apr 19;4(1):17.

Neufeld SQ, Hibbert AD, Chen BE. Opposing Roles of PlexinA and PlexinB in Axonal Branch and Varicosity Formation. Mol Brain. 2011 Apr 13;4(1):15.

Redensek A, Rathore KI, Berard JL, López-Vales R, Swayne LA, Bennett SA, Mohri I, Taniike M, Urade Y, David S. Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury. Glia. 2011 Apr;59(4):603-14.

March 2011

Congratulations to Drs. Sal Carbonetto (Principal Investigator), Brian Chen, Sam David, Keith Murai, Yong Rao, and Don van Meyel for receiving infrastructure funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) for the project titled “Confocal laser scanning microscope for high-resolution, 3-dimensional imaging in neuroscience."

The CRN congratulates Dr. Keith Murai for receiving a grant from the Natural Sciences and Engineering Research Council of Canada (NSERC) for a project titled, "Crosstalk between inhibitory and excitatory neurotransmitter systems during synapse development in the brain."

CRN Publications

Jones EV, Bernardinelli Y, Tse YC, Chierzi S, Wong TP, Murai KK. Astrocytes control glutamate receptor levels at developing synapses through SPARC-beta-integrin interactions. JJ Neurosci. 2011 Mar 16;31(11):4154-65.

February 2011

Dr. Brian Chen is the recipient of a 2011 Sloan Research Fellowship provided by the Alfred P. Sloan Foundation. This award recognizes outstanding scholars in the fields of science, mathematics, economics and computer science. The CRN congratulates Dr. Chen on receiving this prestigious award.

January 2011

The CRN congratulates Dr. Eric Trudel for receiving the inaugural Medstar Award from McGill University. This award helps recognize excellent research performed at the Faculty of Medicine. Dr. Trudel received this award through his groundbreaking work on the role of the body's central clock in regulating vasopressin neurons in the hypothalamus (Nature Neuroscience (2010) 13:467-74).

CRN Publications

Stellwagen D. The contribution of TNFα to synaptic plasticity and nervous system function. Adv Exp Med Biol. 2011;691:541-57.


 

2010

December 2010

CRN Publications

Sudbury JR, Ciura S, Sharif-Naeini R, Bourque CW. Osmotic and thermal control of magnocellular neurosecretory neurons--role of an N-terminal variant of trpv1. Eur J Neurosci. 2010 Dec;32(12):2022-30.

Murai KK, Pasquale EB. Restraining stem cell niche plasticity: a new talent of Eph receptors. Cell Stem Cell. 2010 Dec 3;7(6):647-8.

November 2010

CRN founder, Dr. Albert Aguayo, is inducted into the Canadian Medical Hall of Fame. The CRN would like to congratulate Dr. Aguayo on this tremendous career achievement.

The CRN congratulates Dr. Yong Rao for receiving a grant from the China-Canada Joint Health Research Initiative for a project titled, "Genetic and drug screen for modulators of aggressive behavior in genetic model systems."

CRN Publications

Berard JL, Kerr BJ, Johnson HM, David S. Differential expression of SOCS1 in macrophages in relapsing-remitting and chronic EAE and its role in disease severity. Glia. 2010 Nov 15;58(15):1816-26.

Camp D, Currie K, Labbé A, van Meyel DJ, Charron F. Ihog and Boi are essential for Hedgehog signaling in Drosophila. Neural Dev. 2010 Nov 2;5:28.

October 2010

CRN Publications

Cameron S, Rao Y. Molecular mechanisms of tiling and self-avoidance in neural development. Mol Brain. 2010 Oct 11;3(1):28.

Ghasemlou N, Lopez-Vales R, Lachance C, Thuraisingam T, Gaestel M, Radzioch D, David S. Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury. J Neurosci. 2010 Oct 13;30(41):13750-9.

Stacey SM, Muraro NI, Peco E, Labbé A, Thomas GB, Baines RA, van Meyel DJ. Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion. J Neurosci. 2010 Oct 27;30(43):14446-57.

September 2010

CRN Publications

Yu L, Zhou Y, Cheng S, Rao Y. Plexin a-semaphorin-1a reverse signaling regulates photoreceptor axon guidance in Drosophila. J Neurosci. 2010 Sep 8;30(36):12151-6.

June 2010

CRN Publications

Houalla T, Shi L, van Meyel DJ, Rao Y. Rab-mediated vesicular transport is required for neuronal positioning in the developing Drosophila visual system. Mol Brain. 2010 Jun 11;3:19.

May 2010

Dr. Sam David is elected as Vice President of the Canadian Association for Neuroscience (CAN). Other members of the CAN executive include Dr. Yves De Koninck (President, U. Laval); Dr. Jaideep Bains (Secretary, U. Calgary); and Dr. Keith Murai (Treasurer).

The CRN congratulates Denise Cook, Scott Cameron and Dr. Emma Jones for their recent publication in the Journal of Neuroscience reviewing the role of Fragile X Mental Retardation Protein in regulating protein translation in neurons.

CRN Publications

Zhan Y, Melian NY, Pantoja M, Haines N, Ruohola-Baker H, Bourque CW, Rao Y, Carbonetto S. Dystroglycan and mitochondrial ribosomal protein l34 regulate differentiation in the Drosophila eye.PLoS One. 2010 May 5;5(5):e10488.

Cook D, Cameron S, Jones EV. Fragile X Mental Retardation Protein: Regulator of Specific mRNAs or Master Regulator of Global Translation? J Neurosci. 2010 May 26;30(21):7121-3.

April 2010

Dr. Michael Rasminsky receives the honorific title of Emeritus Professor at McGill University. The CRN congratulates Dr. Rasminsky on this tremendous achievement.

The CRN congratulates Dr. David Stellwagen for receiving a CIHR New Investigator Salary Award

CRN Publications

Bouvier D, Tremblay ME, Riad M, Corera AT, Gingras D, Horn KE, Fotouhi M, Girard M, Murai KK, Kennedy TE, McPherson PS, Pasquale EB, Fon EA, Doucet G. EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. J Neurochem. 2010 Apr;113(1):153-65.

Trudel E, Bourque CW. Central clock excites vasopressin neurons by waking osmosensory afferents during late sleep. Nat Neurosci. 2010 Apr;13(4):467-74.

March 2010

CRN Publications

López-Vales R, Redensek A, Skinner TA, Rathore KI, Ghasemlou N, Wojewodka G, DeSanctis J, Radzioch D, David S. Fenretinide promotes functional recovery and tissue protection after spinal cord contusion injury in mice. J Neurosci. 2010 Mar 3;30(9):3220-6.

February 2010

Research from the laboratory of Dr. Charles Bourque discovers how the body prevents itself from dehydration during the night by modifying the activity of specific neural circuits in the brain that control fluid balance. See the official press release below by the journal Nature.

Nature Press Office

Neuroscience: Getting through the night without a drink

DOI: 10.1038/nn.2503

The changes which our body orchestrates that prevent dehydration at night, when we sleep are reported in a study published online this week in Nature Neuroscience. The amount of water retained by the body is controlled by vasopressin, a hormone released by neurosecretory cells in a brain area known as the hypothalamus. These cells are activated by osmosensory cells, which track the concentration of water in blood. The hypothalamus also contains cells that form the suprachiasmatic nucleus, which is thought to contain a central body clock. Daily, rhythmic changes in the activity of the cells in this nucleus influences all of the body's daily rhythms, from when we feel hungry to when we feel sleepy. Eric Trudel and Charles Bourque studied the connection between these three groups of cells. They found that late at night, the connection between the water-sensing osmosensory cells and the vasopressin-releasing neurosecretory cells grows stronger, so that even slight dehydration results in a greater release of vasopressin. Also at this time of the night, activity in the suprachiasmatic nucleus reduces. The team artificially increased the firing of the suprachiasmatic nucleus cells and found that the connection between the osmosensory and neurosecretory cells grew weaker. These results suggest that that activation of the suprachiasmatic nucleus weakens the connection between osmosensory and neurosecretory cells, acting like a 'brake.' During the day, we can remedy low water concentrations merely by drinking some water. However, when we sleep during the night, the activity in the suprachiasmatic nucleus reduces, releasing the 'brake', and allowing more water retention.

CRN Publications

Prager-Khoutorsky M, Bourque CW. Osmosensation in vasopressin neurons: changing actin density to optimize function. Trends Neurosci. 2010 Feb;33(2):76-83.

January 2010

CRN Publications

Ghasemlou N, Bouhy D, Yang J, López-Vales R, Haber M, Thuraisingam T, He G, Radzioch D, Ding A, David S. Beneficial effects of secretory leukocyte protease inhibitor after spinal cord injury. Brain. 2010 Jan;133(Pt 1):126-38.

Girolami EI, Bouhy D, Haber M, Johnson H, David S.Differential expression and potential role of SOCS1 and SOCS3 in Wallerian degeneration in injured peripheral nerve. Exp Neurol. (In Press).

López-Vales R, Redensek A, Skinner TAA, Rathore KI, Ghasemlou N, Wojewodka G, DeSanctis J, Radzioch D, David S. Fenretinide promotes functional recovery and tissue protection after spinal cord contusion injury in mice. Journal of Neuroscience (In Press).

 


2009

December 2009

Congratulations to Dr. Brian Chen who has been appointed the Tier II Canada Research Chair (CRC) in Neural Circuit Formation. He also received funding from the Canadian Foundation for Innovation (CFI) for the construction of a "Facility for High-Resolution in vivo Imaging of Synapse Dynamics in Multiple Model Systems."

CRN Publications

Prager-Khoutorsky M, Bourque CW. Osmosensation in vasopressin neurons: changing actin density to optimize function. Trends Neurosci. 2009 Dec 4. E-Pub ahead of print

November 2009

CRN Publications

Ferguson K, Long H, Cameron S, Chang WT, Rao Y. The conserved Ig superfamily member Turtle mediates axonal tiling in Drosophila. J Neurosci. 2009 Nov 11;29(45):14151-9.

Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, Lavoie MJ, Slack RS, Rao Y, Zhang Z, Lu B, Haque ME, Park DS. Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet. 2009 Nov 15;18(22):4390-404.

October 2009

CRN Publications

Long H, Ou Y, Rao Y, van Meyel DJ. Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila. Development. 2009 Oct;136(20):3475-84.

September 2009

CRN Publications

Berard JL, Wolak K, Fournier S, David S. Characterization of relapsing-remitting and chronic forms of experimental autoimmune encephalomyelitis in C57BL/6 mice. Glia. 2009 Sep 24;58(4):434-445.

Fry EJ, Chagnon MJ, López-Vales R, Tremblay ML, David S.Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice. Glia. 2009 Sep 24;58(4):423-433.

July 2009

CRN Publications

Carmona MA, Murai KK, Wang L, Roberts AJ, Pasquale EB. Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12524-9.

Haber M, Vautrin S, Fry EJ, Murai KK. Subtype-specific oligodendrocyte dynamics in organotypic culture. Glia. 2009 Jul;57(9):1000-13.

June 2009

Congratulations to Dr. Don van Meyel who received a three year Hugh and Helen McPherson Memorial Award through the McGill Faculty of Medicine.

The CRN congratulates Jessica Sudbury in the lab of Dr. Charles Bourque who received a 3 year Canada Graduate Scholarship Doctoral Award from CIHR.

The CRN congratulates Dr. Masha Khoutorsky in the lab of Dr. Charles Bourque who received a 2 year Postdoctoral Fellowship from the Heart and Stroke Foundation of Canada.

May 2009

CRN Publications

Kalyvas A, Baskakis C, Magrioti V, Constantinou-Kokotou V, Stephens D, López-Vales R, Lu JQ, Yong VW, Dennis EA, Kokotos G, David S. Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis. Brain. 2009 May;132(Pt 5):1221-35.

April 2009

Congratulations to Dr. Don van Meyel who was awarded a multi-year NSERC Discovery Grant titled: "Discovery and analysis of genes that govern axon guidance in the developing nervous system"

Congratulations to Dr. Sam David and colleagues who were awarded a 6 year CIHR grant for an "Integrated Training Program in Basic and Clinical Aspects of Neuroinflammation."

February 2009

CRN Publications

Tremblay ME, Riad M, Chierzi S, Murai KK, Pasquale EB, Doucet G. Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus. J Comp Neurol. 2009 Feb 20;512(6):798-813.

January 2009

Congratulations to Dr. Don van Meyel who received a 5 year grant from CIHR titled, "Glial cell differentiation, function and neuron-glial interactions in the CNS."

Congratulations to Dr. Sam David who received a 5 year grant from CIHR titled, "Molecular mechanisms underlying the onset and resolution of macrophage activation in the nervous system: implications for neural injury and repair."

We are pleased to announce the arrival of Dr. Brian Chen (Assistant Professor in the Departments of Neurology & Neurosurgery and Medicine) at the Centre for Research in Neuroscience. Dr. Chen obtained his Ph.D. at the Cold Spring Harbor Laboratory and performed postdoctoral work at Harvard. His research is focused on understanding mechanisms involved in brain wiring and plasticity using invertebrate and vertebrate model systems.

CRN Publications

Schmucker D, Chen B. Dscam and DSCAM: complex genes in simple animals, complex animals yet simple genes. Genes Dev. 2009 Jan 15;23(2):147-56.

Jeong SY, Rathore KI, Schulz K, Ponka P, Arosio P, David S. Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis. J Neurosci. 2009 Jan 21;29(3):610-9.

 


2008

December 2008

CRN Publications

Piton A, Michaud JL, Peng H, Aradhya S, Gauthier J, Mottron L, Champagne N, Lafrenière RG, Hamdan FF; S2D team, Joober R, Fombonne E, Marineau C, Cossette P, Dubé MP, Haghighi P, Drapeau P, Barker PA, Carbonetto S, Rouleau GA. Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Hum Mol Genet. 2008 Dec 15;17(24):3965-74.

Salomon SN, Haber M, Murai KK, Dunn RJ. Localization of the Diaphanous-related formin Daam1 to neuronal dendrites. Neurosci Lett. 2008 Dec 5;447(1):62-7.

Novemeber 2008

CRN Publications

Martini R, Fischer S, López-Vales R, David S. Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease. Glia. 2008 Nov 1;56(14):1566-77.

Rathore KI, Kerr BJ, Redensek A, López-Vales R, Jeong SY, Ponka P, David S. Ceruloplasmin protects injured spinal cord from iron-mediated oxidative damage. J Neurosci. 2008 Nov 26;28(48):12736-47.

September 2008

Drs. Stellwagen and Murai receive a 2 year NIH grant to study the role of glial-derived TNF-alpha in regulating the structural and functional properties of synapses in response to drugs of abuse.

CRN Publications

Martini R, Fischer S, López-Vales R, David S. Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease. Glia. 2008 Sep 19;56(14):1566-1577.

Piton A, Michaud JL, Peng H, Aradhya S, Gauthier J, Mottron L, Champagne N, Lafrenière RG, Hamdan FF; S2D team, Joober R, Fombonne E, Marineau C, Cossette P, Dubé MP, Haghighi P, Drapeau P, Barker PA, Carbonetto S, Rouleau GA. Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Hum Mol Genet. 2008 Sep 18. [Epub ahead of print]

Sharif-Naeini R, Ciura S, Stachniak TJ, Trudel E, Bourque CW. Neurophysiology of supraoptic neurons in C57/BL mice studied in three acute in vitro preparations. Prog Brain Res. 2008;170:229-42.

Zhou C, Rao Y, Rao Y. A subset of octopaminergic neurons are important for Drosophila aggression. Nat Neurosci. 2008 Sep;11(9):1059-67.

Zhang Z, Bourque CW. Amplification of transducer gain by angiotensin II-mediated enhancement of cortical actin density in osmosensory neurons. J Neurosci. 2008 Sep 17;28(38):9536-44.

August 2008

CRN Publications

López-Vales R, Navarro X, Shimizu T, Baskakis C, Kokotos G, Constantinou-Kokotou V, Stephens D, Dennis EA, David S. Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Aug 21.

July 2008

Congratulations to Dr. Yann Bernardinelli (Murai Lab) who received a 1.5 year fellowship from the Fonds National Suisse De La Recherche Scientifique to study the role of glial cells in synaptic function.

CRN Publications

Bourque CW. Central mechanisms of osmosensation and systemic osmoregulation. Nat Rev Neurosci. 2008 Jul;9(7):519-31. Epub 2008 May 29.

Bouvier D, Corera AT, Tremblay ME, Riad M, Chagnon M, Murai KK, Pasquale EB, Fon EA, Doucet G. Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain. J Neurochem. 2008 Jul;106(2):682-95.

Ou Y, Chwalla B, Landgraf M, van Meyel DJ. Identification of genes influencing dendrite morphogenesis in developing peripheral sensory and central motor neurons. Neural Develop. 2008 Jul 10;3:16.

June 2008

CRN Publications

Kaneko M, Stellwagen D, Malenka RC, Stryker MP. Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex. Neuron. 2008 Jun 12;58(5):673-80.

May 2008

CRN Publications

David S, Fry EJ, López-Vales R. Novel roles for Nogo receptor in inflammation and disease. Trends Neurosci. 2008 May;31(5):221-6.

April 2008

Congratulations to the members of the Bourque Laboratory who recently received independent fellowships. Jessica Sudbury received a Doctoral Award from the FRSQ (Fonds de la Recherche en Sante du Quebec) and Tevye Stachniak was awarded a Doctoral Award from the HSFC (Heart and Stroke Foundation of Canada).

CRN Publications

Bouvier D, Corera AT, Tremblay ME, Riad M, Chagnon M, Murai KK, Pasquale EB, Fon EA, Doucet G. Presynaptic and postsynaptic localization of EphA4 and EphB2 in adult mouse forebrain. J Neurochem. 2008 Apr 12; [Epub ahead of print]

David S, Fry EJ, López-Vales R. Novel roles for Nogo receptor in inflammation and disease. Trends Neurosci. 2008 Apr 3. [Epub ahead of print]

Murai KK, Pasquale EB. Neuroscience. Axons seek neighborly advice. Science. 2008 Apr 11;320(5873):185-6.

Peng H, Shah W, Holland P, Carbonetto S. Integrins and dystroglycan regulate astrocyte wound healing: The integrin beta1 subunit is necessary for process extension and orienting the microtubular network. Dev Neurobiol. 2008 Apr;68(5):559-74.

Sharif-Naeini R, Ciura S, Bourque CW. TRPV1 gene required for thermosensory transduction and anticipatory secretion from vasopressin neurons during hyperthermia. Neuron. 2008 Apr 24;58(2):179-85.

Sharif-Naeini R, Ciura S, Zhang Z, Bourque CW. Contribution of TRPV channels to osmosensory transduction, thirst, and vasopressin release. Kidney Int. 2008 Apr;73(7):811-5.

Tahvildari B, Alonso AA, Bourque CW. Ionic Basis of ON and OFF Persistent Activity in Layer III Lateral Entorhinal Cortical Principal Neurons. J Neurophysiol. 2008 Apr;99(4):2006-11.

March 2008

CRN Publications

Kerr BJ, Girolami EI, Ghasemlou N, Jeong SY, David S. The protective effects of 15-deoxy-delta-(12,14)-prostaglandin J2 in spinal cord injury. Glia. 2008 Mar;56(4):436-48.

January 2008

We are pleased to announce the arrival of Dr. David Stellwagen as an Assistant Profesor in the Departments of Medicine and Neurology and the Centre for Research in Neuroscience. Dr. Stellwagen obtained a B.Sc. from Brown University and a PhD in Molecular and Cell Biology at Berkeley. He has 13 publications focused largely on understanding the mechanisms of synaptic remodeling in the brain.


2007

December 2007

CRN Publications

Murai, KK, van Meyel, D.J. Neuron-glial communication at synapses: insights from vertebrates and invertebrates. The Neuroscientist. 2007 Dec;13(6):657-66.

Richter M, Murai KK, Bourgin C, Pak DT, Pasquale EB. The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. J Neurosci. 2007 Dec 19;27(51):14205-15.

November 2007

CRN Publications

Brown CH, Scott V, Ludwig M, Leng G, Bourque CW. Somatodendritic dynorphin release: orchestrating activity patterns of vasopressin neurons. Biochem Soc Trans. 2007 Nov;35(Pt 5):1236-42.

September 2007

CRN Publications

Bourgin C, Murai KK, Richter M, Pasquale EB. The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways. J Cell Biol. 2007 Sep 24;178(7):1295-307.

Khawaja FA, Alonso AA, Bourque CW. Ca(2+)-dependent K(+) currents and spike-frequency adaptation in medial entorhinal cortex layer II stellate cells. Hippocampus. 2007;17(12):1143-8.

Stacey, S, Thomas, GB, Labbe, A, van Meyel, DJ. Longitudinal glia in the fly CNS: pushing the envelope on glial diversity and neuron-glial interactions Neuron-Glia Biology 2007 3(1):27-33.

August 2007

Drs. Louis Eric-Trudeau (U. of Montreal), Yong Rao (CRN), Edward Fon (MNI), David Park (U. Ottawa), Heidi McBride (U. Ottawa), and Michael Schlossmacher (U. Ottawa) receive a three year Team Grant Award from Neuroscience Canada Titled, "Mitochondrial dysfunction and neuronal demise: insights provided by Parkinson's disease genes." The award is for $1,500,000 over the 2007-2010 period.

CRN Publications

Kerr BJ, David S. Pain behaviors after spinal cord contusion injury in two commonly used mouse strains. Exp Neurol. 2007 Aug;206(2):240-7.

Mindorff, EN, O'Keefe DD, Labbe, A, Yang, JP, Ou, Y, Yoshikawa, S, van Meyel, DJ. A gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein Dorsal and reveals a requirement for the kinase Pelle in Drosophila photoreceptor axon targeting Genetics. 2007 176(4):2247-63.

July 2007

CRN Publications

Ellis LD, Krahe R, Bourque CW, Dunn RJ, Chacron MJ. Muscarinic receptors control frequency tuning through the downregulation of an A-type potassium current. J Neurophysiol. 2007 Jul 5 [e-pub ahead of print].

June 2007

Drs. Rob Dunn and Pierre Drapeau (University of Montreal) receive a five year grant from CIHR on "Developmental plasticity of the spinal cord synaptic drive."

CRN Publications

De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, Kaplan J. Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J. 2007 Jun 20;26(12):2823-31.

May 2007

CRN Publications

Bourque CW, Ciura S, Trudel E, Stachniak TJ, Sharif-Naeini R. Neurophysiological characterisation of osmosensitive neurons. Exp Physiol. 2007 May;92(3):499-505.

Kerr BJ, David S. Pain behaviors after spinal cord contusion injury in two commonly used mouse strains. Exp Neurol. 2007 May 21 [Epub ahead of print].

Zhou L, Martinez SJ, Haber M, Jones EV, Bouvier D, Doucet G, Corera AT, Fon EA, Zisch AH, Murai KK. EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology. J Neurosci. 2007 May 9;27(19):5127-38.

April 2007

CRN Publications

Zhang Z, Kindrat AN, Sharif-Naeini R, Bourque CW. Actin filaments mediate mechanical gating during osmosensory transduction in rat supraoptic nucleus neurons. J Neurosci. 2007 Apr 11; 27(15): 4008-4013.

Tremblay ME, Riad M, Bouvier D, Murai KK, Pasquale EB, Descarries L, Doucet G. Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus. J Comp Neurol. 2007 Apr 10;501(5):691-702.

March 2007

Glezer I, Chernomoretz A, David S, Plante MM, Rivest S. Genes Involved in the Balance between Neuronal Survival and Death during Inflammation. PLoS ONE. 2007 Mar 21;2:e310.

Reza Sharif-Naeini from the lab of Dr. Charles Bourque was recently awarded CIHR's Brain Star Award (seehttp://www.cihr-irsc.gc.ca/e/33053.html). Reza was also recently awarded a prestigious Human Frontiers Long Term Fellowship Award for Postdoctoral studies to be pursued in France.

A recent paper by Graham Thomas and Dr. Don van Meyel was selected as a Research Highlight in the March 2007 Update of Nature Publishing Group's Functional Glycomics Gateway.

CRN Publications

Fry EJ, Ho C, David S. A role for Nogo receptor in macrophage clearance from injured peripheral nerve. Neuron. 2007 Mar 1;53(5):649-62.

February 2007

Dr. Keith Murai receives a five year grant from CIHR on "Neuron-glial mechanisms that regulate synaptic morphology and function."

CRN Publications

Ghasemlou N, Jeong SY, Lacroix S, David S. T cells contribute to lysophosphatidylcholine-induced macrophage activation and demyelination in the CNS. Glia. 2007 Feb;55(3):294-302.

Thomas GB, van Meyel DJ. The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression. Development. 2007 Feb;134(3):591-600.

January 2007

CRN investigators Drs. Sal Carbonetto, Yong Rao, Don van Meyel and Keith Murai, and investigators Drs. Patrick Cossette (University of Montreal, Neurology), Chieh Chang (McGill, Biology), David Juncker (McGill, Biomedical Engineering), Anne McKinney (McGill, Pharmacology), and Guy Rouleau (Univ. of Montreal, Neurology), receive a 5 year award for a team grant titled "Reorganization of Brain Microcircuits" from CIHR (Regenerative Medicine and Nanomedicine Initiative).


2006

December 2006

CRN Publications

Sharif Naeini R, Ciura S, Bourque CW. TRPVs: ion channels that make you thirsty! Med Sci (Paris). 2006 Dec;22(12):1035-1037.

September 2006

CRN Publications

Jeong SY, David S. Age-related changes in iron homeostasis and cell death in the cerebellum of ceruloplasmin-deficient mice. J Neurosci. 2006 Sep 20;26(38):9810-9.

August 2006

CRN Publications

Ciura S, Bourque CW. Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. J. Neurosci. 2006 August 30;26(35):9069-9075.

Haber M, Zhou L, Murai KK. Cooperative Astrocyte and Dendritic Spine Dynamics at Hippocampal Excitatory Synapses. J. Neurosci. 2006 August 30;26(35):8881-8891.

Research studies from the laboratories of Dr. Charles Bourque and Dr. Keith Murai are picked as featured articles for the August 30th issue of the Journal of Neuroscience.

July 2006

Dr. Don van Meyel receives a one year Development / Planning Grant (International Opportunities Program) from the Canadian Institutes of Health Research (Institute of Genetics) on "Genetic control of the development of dendrites."

Dr. Sal Carbonetto receives a three year grant from the Canadian Institutes of Health Research/Neuromuscular Research Partnership on "Dystroglycan function and dysfunction in the fly CNS."

June 2006

Dr. Sal Carbonetto receives a three year grant from the Muscular Dystrophy Association on "Dystroglycan in neuromuscular synapse formation."

CRN Publications

McDearmid JR, Liao M, Drapeau P. Glycine receptors regulate interneuron differentiation during spinal network development. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9679-84.

Mehaffey WH, Fernandez FR, Rashid AJ, Dunn RJ, Turner RW. Distribution and function of potassium channels in the electrosensory lateral line lobe of weakly electric apteronotid fish. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2006 Jun;192(6):637-48.

Panatier A, Gentles SJ, Bourque CW, Oliet SH. Activity-dependent synaptic plasticity in the supraoptic nucleus of the rat hypothalamus. J Physiol. 2006 Jun 15;573(Pt 3):711-21.

May 2006

CRN Publications

Brown CH, Leng G, Ludwig M, Bourque CW. Endogenous Activation of Supraoptic Nucleus {kappa}-Opioid Receptors Terminates Spontaneous Phasic Bursts in Rat Magnocellular Neurosecretory Cells. J Neurophysiol. 2006 May;95(5):3235-44.

Chakfe Y, Zhang Z, Bourque CW. IL-1beta directly excites isolated rat supraoptic neurons via upregulation of the osmosensory cation current. Am J Physiol Regul Integr Comp Physiol. 2006 May;290(5):R1183-90.

Tremblay MR, Carbonetto S. An extracellular pathway for dystroglycan function in acetylcholine receptor aggregation and laminin deposition in skeletal myotubes. J Biol Chem. 2006 May 12;281(19):13365-73.

April 2006

Dr. Yong Rao receives a Chercheurs-Boursiers (Senior Level) from the FRSQ on "Établissement de circuits neuronaux durant le développement"

CRN Publications

Cafferty P, Yu L, Long H, Rao Y. Semaphorin-1a functions as a guidance receptor in the Drosophila visual system. J Neurosci. 2006 Apr 12;26(15):3999-4003.

March 2006

CRN Publications

Long H, Cameron S, Yu L, Rao Y. De novo GMP synthesis is required for axon guidance in Drosophila. Genetics. 2006 Mar;172(3):1633-42.

Shah WA, Peng H, Carbonetto S. Role of non-raft cholesterol in lymphocytic choriomeningitis virus infection via alpha-dystroglycan. J Gen Virol. 2006 Mar;87(Pt 3):673-8.

Zhang Z, Bourque CW. Calcium permeability and flux through osmosensory transduction channels of isolated rat supraoptic nucleus neurons. Eur J Neurosci. 2006 Mar;23(6):1491-500.

February 2006

CRN Publications

Brown CH, Bourque CW. Mechanisms of rhythmogenesis: insights from hypothalamic vasopressin neurons. Trends Neurosci. 2006 Feb;29(2):108-15.

Stachniak TJ, Bourque CW. Visually guided whole cell patch clamp of mouse supraoptic nucleus neurons in cultured and acute conditions. Am J Physiol Regul Integr Comp Physiol. 2006 Feb 9.

January 2006

Dr. Samuel David receives a Proof of Principle Grant from the CIHR on "Pre-clinical testing of novel phospholipase A2 inhibitors for the treatment of multiple sclerosis"

Dr. Keith Murai receives a Scholar Research Award from The EJLB Foundation on "Characterizing dynamic neuron-glial interactions that regulate synapse structure and function"

CRN Publications

Haber M, Murai KK. Reshaping neuron-glial communication at hippocampal synapses. Neuron Glia Biology 2006 Jan;2:59-66.

McDearmid JR, Drapeau P. Rhythmic motor activity evoked by NMDA in the spinal zebrafish larva. J Neurophysiol. 2006 Jan;95(1):401-17.

Sharif Naeini R, Witty MF, Seguela P, Bourque CW. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci. 2006 Jan;9(1):93-8.


2005

December 2005

CRN Publications

Deng Q, Rashid AJ, Fernandez FR, Turner RW, Maler L, Dunn RJ. A C-terminal domain directs Kv3.3 channels to dendrites. J Neurosci. 2005 Dec 14;25(50):11531-41.