Publications on Fungal Infections

1. Rodionov, D., Romero, P. A., Berghuis, A.M., Herscovics, A. (2009) Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity, Protein Expression and Purification 66, 1-6.

2. Mirza, I. A., Nazi, I., Korczynska, M., Wright, G. D., and Berghuis, A. (2005) Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases, Biochemistry 44, 15768-15773.

3. Ejim, L., Mirza, I. A., Capone, C., Nazi, I., Jenkins, S., Chee, G. L., Berghuis, A., and Wright, G. D. (2004) New phenolic inhibitors of yeast homoserine dehydrogenase, Bioorganic & Medicinal Chemistry 12, 3825-3830.

4. Jacques, S. L., Mirza, I. A., Ejim, L., Koteva, K., Hughes, D. W., Green, K., Kinach, R., Honek, J. F., Lai, H. K., Berghuis, A., and Wright, G. D. (2003) Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase, Chemistry & Biology 10, 989-995.

5. DeLaBarre, B., Thompson, P. R., Wright, G. D., and Berghuis, A. M. (2000) Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases, Nat Struct Biol 7, 238-244.

6. DeLaBarre, B., Jacques, S. L., Pratt, C. E., Ruth, D. A., Wright, G. D., and Berghuis, A. M. (1998) Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae, Acta Crystallogr D Biol Crystallogr 54, 413-415.

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