Antibiotic Resistance

1. Fong, D. H., Lemke, C. T., Hwang, J., Xiong, B., Berghuis, A. M. (2010) Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila, J Biol Chem 285, 9545-9555

2. Fong, D. H., Berghuis, A. M. (2009) Structural basis of APH(3')-IIIa-mediated resistance to N1-substituted aminoglycoside antibiotics, Antimicrobial Agents and Chemotherapy 53, 3049-3055.

3. Korczynska, M., Mukhtar, T. A., Wright, G. D., and Berghuis, A. (2007) Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase, Proc Natl Acad Sci USA 104, 10388-10393.

4. Burk, D. L., Hwang, J., Kwok, E., Marrone, L., Goodfellow, V., Dmitrienko, G. I., and Berghuis, A. M. (2007) Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae, Journal of Molecular Biology 373, 745-754.

5. Fong, D., Yim, V. C., D'Elia, M. A., Brown, E. D., and Berghuis, A. (2006) Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism, Biochim Biophys Acta 1764, 63-69.

6. Lemke, C., Hwang, J., Xiong, B., Cianciotto, N., and Berghuis, A. (2005) Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila, Acta Crystallogr F Struct Biol Cryst Commun 61, 606-608.

7. Gao, F., Yan, X., Baettig, O., Berghuis, A., and Auclair, K. (2005) Regio- and chemoselective 6'-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6'-N-acetyltransferases, Angew Chem Int Ed Engl 44, 6859-6862.

8. Burk, D., Xiong, B., Breitbach, C., and Berghuis, A. (2005) Structures of aminoglycoside acetyltransferase AAC(6')-Ii in a novel crystal form: structural and normal-mode analyses, Acta Crystallogr D Biol Crystallogr 61, 1273-1279.

9. Fong, D., and Berghuis, A. (2004) Crystallization and preliminary crystallographic analysis of 3′-aminoglycoside kinase type IIIa complexed with a eukaryotic protein kinase inhibitor, CKI-7, Acta Crystallogr D Biol Crystallogr 60, 1897-1899.

10. Burk, D., Ghuman, N., Wybenga-Groot, L. E., and Berghuis, A. (2003) X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members, Protein Sci 12, 426-437.

11. Thompson, P. R., Boehr, D. D., Berghuis, A., and Wright, G. D. (2002) Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop, Biochemistry 41, 7001-7007.

12. Fong, D., and Berghuis, A. (2002) Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry, EMBO J 21, 2323-2331.

13. Burk, D., and Berghuis, A. (2002) Protein kinase inhibitors and antibiotic resistance, Pharmacol Ther 93, 283-292.

14. Burk, D. L., Hon, W. C., Leung, A. K., and Berghuis, A. M. (2001) Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase, Biochemistry 40, 8756-8764.

15. Wybenga-Groot, L. E., Draker, K., Wright, G. D., and Berghuis, A. M. (1999) Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold, Structure 7, 497-507.

16. Thompson, P. R., Schwartzenhauer, J., Hughes, D. W., Berghuis, A. M., and Wright, G. D. (1999) The COOH terminus of aminoglycoside phosphotransferase (3')-IIIa is critical for antibiotic recognition and resistance, J Biol Chem 274, 30697-30706.

17. Wright, G. D., Berghuis, A. M., and Mobashery, S. (1998) Aminoglycoside antibiotics. Structures, functions, and resistance, Adv Exp Med Biol 456, 27-69.

18. Hon, W. C., McKay, G. A., Thompson, P. R., Sweet, R. M., Yang, D. S., Wright, G. D., and Berghuis, A. M. (1997) Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases, Cell 89, 887-895.

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