

Publications from TDC and Clinical Epidemiology authors: Latest results from PubMed
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Canadian Antibiotic Prescribing for Sepsis (CAPS) Study: A <em>Post Hoc</em> Analysis of the FABLED Cohort Study
CONCLUSIONS: Empiric therapies for septic patients in Canada were overly broad given the rare isolation of drug-resistant pathogens. Though likely confounded by severity of illness, optimal outcomes were observed when therapy was appropriate relative to the causative pathogen and infectious focus.
Perceptions about hepatitis C and barriers and enablers to screening and treatment among Egyptian immigrants to Canada: a theory-informed qualitative study
CONCLUSION: There is an urgent need to improve access to care for immigrants from endemic countries to eliminate HCV in Canada. We took a systematic, theory-informed approach to understand lived experiences and views among Egyptian immigrants in Canada. We identified key factors contributing to the low uptake of HCV screening and treatment. These findings will inform a theory-based intervention to optimize HCV care in immigrant communities.
Development of machine learning prediction models for systemic inflammatory response following controlled exposure to a live attenuated influenza vaccine in healthy adults using multimodal wearable biosensors in Canada: a single-centre, prospective...
BACKGROUND: Presymptomatic or asymptomatic immune system signals and subclinical physiological changes might provide a more objective measure of early viral upper respiratory tract infections (VRTIs) compared with symptom-based detection. We aimed to use multimodal wearable sensors, host-response biomarkers, and machine learning to predict systemic inflammation following controlled exposure to a live attenuated influenza vaccine, without relying on symptoms.
Multiple anthelmintic drug resistance in the canine hookworm Ancylostoma caninum: AAVP position paper and research needs
Cases of infection with the canine hookworm Ancylostoma caninum that are resistant to all anthelmintic classes registered in the United States of America (USA) for control of this parasite in dogs were first reported in 2019. Termed Multiple Anthelmintic Drug Resistance (MADR), cases have subsequently been reported in pet dogs across the USA. Recent studies using molecular tests that detect mutations known to cause resistance to benzimidazole anthelmintics have revealed an alarming frequency of...
Tracking progress along the WHO Neglected Tropical Diseases Road Map to 2030: A guide to the Gap Assessment Tool (GAT) and results from the 2023-2024 assessment
The monitoring and evaluation (M&E) framework for the World Health Organization (WHO) Neglected Tropical Diseases (NTD) road map includes both quantitative and qualitative assessments of progress at key timepoints up to 2030. These assessments provide critical information to improve programmatic action and identify immediate research needs. Quantitative assessments process multi-sourced data on a predefined number of global indicators. Qualitative assessments are based on results obtained from...
Resurgence of chikungunya in the Indian Ocean Region in 2024-2025
In the wake of a large outbreak in Reunion and Mayotte the GeoSentinel network has been signalling chikungunya cases among returning travellers acquired in multiple African and Asian countries between August 1st 2024 and June 10th 2025. These surveillance data suggest a resurgence of chikungunya in the Indian Ocean Region.
Clinical Practice Guideline-Supported Administration of Monoclonal Antibody Therapy for High-Risk Patients with COVID-19: Experience of a Quaternary Care Centre
CONCLUSION: CPG-supported mAb administration for management of COVID-19 in high-risk patients was associated with favourable clinical outcomes and may be a useful model to guide future therapies.
Antibiotic synergy against <em>Staphylococcus aureus</em>: a systematic review and meta-analysis
Antimicrobial combinations have been extensively evaluated in vitro to identify synergistic combinations for clinical use. Despite the available literature, no studies comprehensively summarize the findings for antimicrobial combinations against Staphylococcus aureus. We performed a systematic review to identify synergistic combinations that may be beneficial for clinical use against S. aureus. The PubMed, Cochrane, and Web of Science databases were queried from inception to February 2024 for...
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing
Over 70% of organic halogens, representing chlorine- and bromine-containing disinfection byproducts (Cl-/Br-DBPs), remain unidentified after 50 years of research. This work introduces a streamlined and cloud-based exposomics workflow that integrates high-resolution mass spectrometry (HRMS) analysis, multistage machine learning, and cloud computing for efficient analysis and characterization of Cl-/Br-DBPs. In particular, the multistage machine learning structure employs progressively different...
In vivo validation of a smart sensor-enabled dressing for remote wound monitoring
Every second, a person with diabetes develops a foot ulcer. At least half of these wounds become infected, which dramatically increases the risk of hospitalization, amputation, and death. Wound environment pH is a possible marker of infection, however, clinical application has yet to be achieved. Herein, we introduce a hydrogel sheet dressing made out of a transparent calcium alginate body, which is embedded by a pH-sensitive color changing dye named α-naphtholphthalein that equilibrates to...
Evidence of Coxiella burnetii and Bartonella species infections among patients with persistent febrile illness in four low- and middle-income countries
CONCLUSIONS: Direct and indirect evidence of C. burnetii or Bartonella sp. infections was observed in persistent fever cases. Further studies are necessary to elucidate the burden of these diseases in LMICs.
Cytomegalovirus-Induced Colitis Presenting as Acute Appendicitis in an Immunocompetent Patient With Ulcerative Colitis
We report a rare case of cytomegalovirus (CMV) colitis presenting radiologically as acute appendicitis in an immunocompetent 71-year-old man known for ulcerative colitis. Although initial imaging revealed acute appendicitis, a lack of clinical improvement with antibiotic therapy prompted further evaluation with colonoscopy, which led to the diagnosis of CMV colitis on a background of mild ulcerative colitis flare. Most individuals infected by CMV will exhibit lifelong latency; however, the virus...
Systems analysis unravels a common rural-urban gradient in immunological profile, function, and metabolic dependencies
Urbanization affects environmental exposures and lifestyle, shaping immune system variation and influencing disease susceptibility and vaccine responses. Here, we present systems analysis of immune profiles across the rural-urban gradient, comparing rural and urban Senegalese with urban Dutch individuals. By integrating single-cell phenotyping, metabolic profiling, and functional analysis, we reveal a trajectory of immune remodeling along the gradient. This includes enrichment of proinflammatory...
Identifying patients at high risk for antibiotic treatment following hospital admission: a predictive score to improve antimicrobial stewardship measures
CONCLUSION: The PILGRIM score effectively identifies newly hospitalized patients likely to receive antibiotics, demonstrating high specificity and PPV. Its application can improve future AMS programs and trial recruitment by facilitating targeted inclusion of patients, especially in the hematological and oncological setting. Further -external and prospective- validation is needed to broaden the model's applicability.
Comparison of ciprofloxacin and aminoglycoside susceptibility testing for ceftriaxone non-susceptible Enterobacterales by disk diffusion and VITEK 2 vs. broth microdilution using updated Clinical and Laboratory Standards Institute breakpoints
CONCLUSIONS: Our findings suggest that both disk diffusion and to a greater extent the AST-N391 card for the VITEK 2 system will overcall non-susceptibility according to current CLSI breakpoints for ciprofloxacin. By contrast, the existing AST-N391 VITEK 2 card can likely be used to correctly infer susceptibility to gentamicin and tobramycin.