(BSc University College of Cape Breton, MSc Lakehead, PhD McGill)
Assistant Professor
Faculty of Science
University of Ontario Institute of Technology
2000 Simcoe St. North, Science Building UA4000
Oshawa, Ontario, L1H 7K4
Tel.: 905-721-3050
Fax: 905-721-3304
[ MailTo('Email','sean.forester [at] uoit.ca',0); ]
Research Interests
The goal of my laboratory is to better understand inhibitory neurotransmission in parasitic heminths. This system is controlled, in large part, by a group of receptors called ligand-gated chloride channels (LGCCs). Specifically, my goal is better understand how this system is organized (at the genomic and functional levels), the biological roles of specific LGCCs and the functional relationships between different classes of channels. This will determine the potential of these channels as future targets for the next generation of anthelmintics.
Selected Publications
- Forrester SG and Pearce EJ (2006)
- Immunobiology of Schistosomes. In: Parasitic Flatworms: Molecular Biology, Biochemistry, Immunology and Physiology. Eds AG Maule and NJ Marks. CAB International pp174-192
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- Forrester SG, Warfel PW and Pearce EJ.(2004)
- Tegument expression of a novel type II receptor serine/threonine kinase in Schistosoma mansoni. Molecular and Biochemical Parasitology 136: 149-156
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- Forrester SG, Beech RN and Prichard RK (2004)
- Agonist enhancement of macrocyclic lactone activity at a glutamate-gated chloride channel subunit from Haemonchus contortus. Biochemical Pharmacology 67: 1019-1024
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- Prichard RK, Forrester SG, Njue A, Feng X, Liu J and Beech RN (2003)
- Receptor mechanisms of antiparasitics. Veterinary Pharmacology and Therapeutics 26 (supp): 29-31
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- Forrester SG, Prichard RK, Dent JA and Beech RN (2003)
- Haemonchus contortus: HcGluCla expressed in Xenopus oocytes forms a glutamate-gated ion channel that is activated by ibotenate and the anti-parasitic drug ivermectin. Molecular and Biochemical Parasitology 129(1):115-121
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- Forrester SG, Prichard RK and Beech RN (2002)
- A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand-binding and modulation of anthelmintic binding by glutamate. Biochemical Pharmacology 63(6):1061-8
