Kakkar Group has two inter-linked themes that are utilized in tandem to address key problems in a number of areas including biology. The research seeks to simplify the design of well-defined functionalized nanostructures through simple and high yield chemistry, and provide opportunities for the rational design of new technologies in drug delivery and diagnostics. Our research is highly interdisciplinary and offers opportunities to advantageously combine principles of synthetic chemistry and materials science.
Nanocarriers serve a critical role in directing drugs to diseased site, and their efficacy is a measure of our ability to manage high morbidity rate diseases. Advances in synthetic methodologies have expanded their scope from linear block-copolymers to branched (miktoarm polymers) and hyperbranched (dendrimers) macromolecules, to hybrids thereof (telodendrimers). Structural diversity is key in understanding and providing solutions to ever increasing complexity of diseases.
Miktoarm Star Polymers: From Basics of Branched Architecture to Synthesis, Self-assembly and Applications.
Editor: Ashok Kakkar
Imaging protocols are integrated and essential components in evaluating the performance of therapeutic interventions, and for early detection and prevention of diseases including atherosclerosis, cancer etc. Functionalized metal based nanostructures such as iron oxide nanoparticles and gold nanoshells offer significant potential in surveying disease sites through magnetic resonance imaging and surface plasmon resonance, respectively.