Dr. Todd Lee
Associate Professor - Department of Medicine, Division of Experimental Medicine
Associate Member - Department of Epidemiology, Biostatistics and Occupational Health
Dr. Lee conducts research in several domains and using numerous methodologies. He is active in observational studies looking at: medication safety, health care resource utilization, and clinical prediction, and the treatment of antimicrobial resistant organisms (AROs). He is involved in laboratory studies evaluating the diagnosis and the treatment of AROs. He is currently conducting randomized clinical trials involving: medication safety (MedSafer), the treatment of Staphylococcus aureus bacteremia, the treatment of Clostridium difficile, the eradication of ARO colonization, and the treatment of cellulitis.
- Identification of novel treatment strategies for carbapenem resistant organisms. This project seeks to evaluate combination antibiotic therapies within the laboratory to determine if unconventional combinations can demonstrate synergistic killing in vitro and then to determine (a) the mechanism of this synergy and (b) rapid tests which can predict combination activity.
- Strategies for prevention of recurrence in Clostridioides (formerly Clostridium) difficile. This project will be completed as part of a CIHR-funded randomized controlled trial involving differing strategies of initial vancomycin dosing in first episdoes or first recurrence. The graduate student would select/be assigned one of the secondary goals of the project.
- Evaluation of fecal microbiota transplant for a variety of clinical purposes including: eradication of ARO colonization, prevention of recurrence of C. difficile, as an adjunctive therapy in oncology or endocrinology applications.