Dr. Josie Ursini-Siegel
Assistant Professor - Department of Oncology
Associate Member - Department of Medicine, Division of Experimental Medicine
1. Define the molecular mechanisms by which the ShcA adaptor protein establishes breast cancer immunosuppression.
2. Determine how ShcA integrates mTOR signaling to promote tumor angiogenesis and control breast cancer metabolism.
3. Determine how the ShcA PTB domain functions as a biological sensor to control breast cancer progression.
4. Determine the importance of p66ShcA-induced epithelial to mesenchymal transition during breast cancer progression.