Dr. Jian Hui Wu

Academic title(s): 

Associate Professor - Department of Oncology
Associate Member - Department of Medicine, Division of Experimental Medicine

Dr. Jian Hui Wu
Contact Information

Lady Davis Institute for Medical Research
Jewish General Hospital
3755 Côte Ste-Catherine Road,
Montreal, Qc, H3T 1E2

(514) 340-8222 ext. 22148
Email address: 
jian.h.wu [at] mcgill.ca
Current research: 

My research focuses on the development of methods in Computational Biology & Chemistry, as well as the application of molecular modeling techniques to problems in Chemistry and Biology.

My recent research involves:

  • Development of computer-based virtual screening techniques for hit discovery and novel methodology for the design of selective small-molecule modulators of specific protein/protein interactions.
  • Studies of the structural and dynamic impact of drug-resistant mutations in drug targets, such as androgen receptor and EGFR, as well as design of small molecules to overcome mutation-related drug resistance in targeted cancer therapy.
  • Discovery of potent small-molecule inhibitors of -glutamylcysteine synthetase and novel inhibitors of SARS main proteinase.
  • Discovery of selective small-molecule modulators of Keap1/Nrf-2 pathways as novel inducers of phase II detoxifying enzymes.
  • Optimization of initial hits by Organic Chemistry and development of protein family-oriented chemical library.

1. Development of novel anti-prostate cancer agents.
2. Chemical modulators of protein-protein interaction as anticancer agents.
3. Intrinsically disordered protein regions as drug targets.

Selected publications: 
Research areas: 
Drug discovery/ Therapeutics
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