Dr. Donna Senger
Associate Member - Department of Medicine, Division of Experimental Medicine
Associate Professor - Department of Oncology
I have had a long-standing interest in the area of brain development and tumorigenesis focusing on both pediatric and adult central nervous system (CNS) tumours including defining the molecular characteristics of highly invasive glioma, investigating cancer stem cells as potential therapeutic targets, establishing in vivo models for preclinical testing and investigating the brain microenvironment and how it impacts the growth and progression of brain tumours. More recently my research has also focused on the identification and implementation of therapeutics for the development of organ specific cancer metastasis and the role inflammatory pathways play in these processes. Specific effort has been directed to the identification of molecules within a specific organs endothelium that mediate the recruitment of innate immune and metastatic cancer cells.
1. Molecular Mechanism underlying liver and lung-specific metastasis.
2. Non-classical mechanisms for leukocyte recruitment.
3. Cellular and non-cellular mediators in the brain tumor microenvironment that promote tumor progression.