Nader Sadeghi

Academic title(s): 

Professor and Chair, Department of Otolaryngology - Head and Neck Surgery McGill University,
Professor, Department of Oncology, McGill
Director of McGill Head and Neck Cancer Program.

Nader Sadeghi


McGill University Health Centre (MUHC - Glen) Hospital
Hospital title: 
Chief of Otolaryngology - Head and Neck Surgery MUHC
Senior Researcher, Research Institute of MUHC
Current research: 

Principal investigator, Neoadjuvant Chemotherapy and Transoral Robotic Surgery for oropharyngeal cancer (NECTORS trial), Robotic surgery in head and neck cancer, cancer biology, human papilloma virus (HPV) and head and neck cancer, liquid biopsy, quality of life and outcomes in head and neck cancer, clinical trials, tumor immune micro-environment

Clinical Interests: 
  • Transoral Robotic Surgery
  • Transoral Laser Microsurgery
  • Head and Neck Oncology
  • Salivary gland surgery
  • Head and Neck Endocrine Surgery
Language(s) spoken: 

Dr. Sadeghi is a graduate of McGill Medicine and residency in Otolaryngology-Head and Neck Surgery. He then completed a fellowship training in Head and Neck Oncology Surgery at Rush-Presbyterian-St. Luke's Medical Center in Chicago. Following his early career at McGill, he moved to George Washington University in Washington, DC, where he served as Professor of Surgery and Director of Head and Neck Surgery. In 2017, he returned to McGill to lead the department and McGill's head and neck cancer care program.
Dr. Sadeghi has an international reputation for his pioneering work in adaptive and personalized approach to oropharyngeal cancer with Transoral Robotic Surgery, defining a new paradigm for oropharyngeal cancer care with neoadjuvant systemic treatment and transoral robotic surgery (NECTORS). He has pioneered the NECTORS approach with early feasibility studies followed by phase II clinical trials, introducing a paradigm change to the field. He lectures internationally on the topic and continues to investigate the field of oropharyngeal cancer with studies of immune enhancement and targeted approaches before surgery to allow less invasive yet more effective surgical care, improving outcomes in cancer cure and, equally important, patients-reported outcomes in quality of life and function after cancer care.

Selected publications: 

last 3 years

1. Semsar-Kazerooni K, Richardson K, Forest VI, Mlynarek A, Hier MP, Sadeghi N, et al. Development and validation of the modified index of fragility in head and neck cancer surgery. J Otolaryngol Head Neck Surg. 2023;52(1):5.

2. Ferrier ST, Tsering T, Sadeghi N, Zeitouni A, Burnier JV. Blood and saliva-derived ctDNA is a marker of residual disease after treatment and correlates with recurrence in human papillomavirus-associated head and neck cancer. Cancer Med. 2023.

3. Morand GB, Antoine Eskander, Rui Fu, John de Almeida, David Goldstein, Hesameddin Noroozi, Ali Hosni, Hadi Seikaly, Paul Tabet, Justin M. Pyne, T. Wayne Matthews, Joseph Dort, Steve Nakoneshny, Apostolos Christopoulos, Houda Bahig, Stephanie Johnson-Obaseki, Nadia Hua, Marc Gaudet, Alborz Jooya, Anthony Nichols, Francisco Laxague, Matthew Cecchini, Jenny Du, Justin Shapiro, Irene Karam, Peter T. Dziegielewski, Krishna Hanubal, Boban Erovic, Stefan Grasl, Joel Davies, Eric Monteiro, Maru Gete, Ian Witterick, Nader Sadeghi, Keith Richardson, George Shenouda, Anastasios Maniakas, Vivianne Landry, Michael Gupta, Kelvin Zhou, Alex M. Mlynarek, Marc Pusztaszeri, Khalil Sultanem, Michael. P. Hier, The Protective Role of Postoperative Radiation therapy In Low and Intermediate-Grade Major Salivary Gland Malignancies: A Study of the Canadian Head & Neck Collaborative Research Initiative, Cancer 2023

4. Melissa Henry, Raphaële Harvey, Lawrence M. Chen, Michael Meaney, Thi Thu Thao Nguyen, Han-Tin Kao, Zeev Rosberger, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Keith Richardson, Celia M.T. Greenwood, David Melnychuk, Phil Gold, Gabrielle Chartier, Martin Black, Marco Mascarella, Christina MacDonald, Nader Sadeghi, Khalil Sultanem, Georges Shenouda, Fabio Cury, Kieran John O'Donnell, Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study, Journal of Affective Disorders,Volume 331,2023,Pages 149-157,

5. Arif R, Marzouki HZ, Silver JA, Al Thomali R, Merdad M, Sadeghi N. Primary prevention of depression in head and neck cancer patients: a scoping review. Eur Arch Otorhinolaryngol. 2023;280(4):1547-1554. doi:10.1007/s00405-022-07783-z

6. Psycharis, S.S., Salameh, S., Turkdogan, S. Razzaq K., Richardson K., Mlynarek A, Huer M., Sadeghi, N. Prioritization of head and neck cancer patient care during the COVID-19 pandemic: a retrospective cohort study. J of Otolaryngol - Head & Neck Surg 52, 15 (2023).

7. Corriveau-Parenteau E, Turkdogan S, Noik M, et al. Clinical Experience of Cytologically Indeterminate Thyroid Nodules Designated as Negative on Molecular Testing Using Thyroseq V3: A Retrospective Cohort Study [published online ahead of print, 2023 Feb 24]. Thyroid. 2023;10.1089/thy.2022.0555. doi:10.1089/thy.2022.0555

8. Jennifer A Silver *, Russell Schwartz, Catherine F Roy, Nader Sadeghi, Melissa Henry Patient reported outcome measures of psychosocial quality of life in oropharyngeal cancer patients: A scoping review, Oncology, Feb 2023

9. Koorosh Semsar Kazerooni1* , Keith Richardson , Véronique Isabelle Forest , Alex Mlynarek , Michael P. Hier , Nader Sadeghi, and Marco. A. Mascarella, Development and validation of the modifed index of fragility in head and neck cancer surgery, Journal of Otolaryngology Head and Neck Surgery, January 6 2023 DOI 10.1186/s40463-022-00607-4

10. Christian R. Moya-Garcia, Hideaki Okuyama, Nader Sadeghi, Jianyu Li, Maryam Tabrizian, Nicole Y. K. Li-Jessen, In Vitro Models for Head and Neck Cancer: Current Status and Future Perspective, Frontiers in Oncology, section Head and Neck Cancer, Accepted June 28, 2022

11. *Jennifer A. Silver, Sena Turkdogan, Catherine F. Roy , Thavakumar Subramaniam, Melissa Henry, and Nader Sadeghi, De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma—Where AreWe Now? Curr. Oncol. 2022, 29 3668-3671 DOI: 10.3390/curroncol29050295

12. Justine Georgina Albert, Christopher Lo, Zeev Rosberger, Saul Frenkiel, Michael P. Hier, Anthony G.Zeitouni, Karen M Kost, Alex Mlynarek, Martin Jacob Black, Christina MacDonald, Keith Richardson, Marco Mascarella, Grégoire B. Morand, Gabrielle Chartier, Nader Sadeghi, Khalil Sultanem, George Shenouda, Fabio Cury, Melissa Henry *Biopsychosocial Markers of Body Image Concerns in Patients with Head and Neck Cancer: A Prospective Longitudinal Study, Curr. Oncol. 2022, 29, 4438–4454.

13. Esther Lee, Hannah R. Crowder, Daniel Gorelik, Christopher Badger, Jennifer Schottler, Ning Wei Li, obert Siegel, Nader Sadeghi, Punam G. Thakkar, Arjun S. Joshi, Joseph F. Goodman. Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer. European Archives of Oto-Rhino-Laryngology, April 2022 10.1007/s00405-022-07387-7

14. Henry M, Albert JG, Frenkiel S, Hier M, Zeitouni A, Kost K, Mlynarek A, Black M, MacDonald C, Richardson K, Mascarella M, Morand GBR, Chartier G, Sadeghi N, Lo C , Zeev Rosberger, Body Image Concerns in Patients With Head and Neck Cancer: A Longitudinal Study, Frontiers in Psychology, section Psycho-Oncology, 20 march 2022

15. Esther Lee1, Daniel Gorelik1, Hannah R. Crowder, Christopher Badger, Jennifer Schottler, Ning-Wei Li, Robert Siegel, Nader Sadeghi, Joseph F. Goodman, Punam G. Thakkar , and Arjun S. Joshi, Swallowing Function Following Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharyngeal Carcinoma: A 2-Year Follow-up. First Otolaryngology-Head and Neck Surgery 2022 Vol. 167, Issue 2,

16. Melissa Henry, Emily Arnovitz, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Martin Black, Christina MacDonald, Keith Richardson, Marco Mascarella, Gregoire B. Morand, Gabrielle Chartier, Nader Sadeghi, Zeev Rosberger, Psychosocial outcomes of HPV- and non-HPV related head and neck cancers: a longitudinal study. Psycho-Oncology, Sept 2021

17. A Mascarella, Marco; Muthukrishnan, Nikesh; Maleki, Farhad; Kergoat, Marie-Jeanne; Richardson, Keith; Mlynarek, Alex; Forest, Veronique-Isabelle; Reinhold, Caroline; Martin, Diego; Hier, Michael; Sadeghi, Nader; Forghani, Reza. Above and Beyond Age: Prediction of major postoperative adverse events in head and neck surgery. Annals of Otology, Rhinology & Laryngology August 20, 2021, Vol. 131(7) 697–703,

18. Henry M, Sargi E., Frenkiel S., Hier M., Zeitouni A., Kost K., Mlynarek A., Martin Black M., MacDonald C., Richardson K,. Chartier G., Sadeghi N., Rosberger Z., Longitudinal Study Indicating Antecedent Psychosocial Vulnerability as Predictor of Anxiety Disorders Post-Treatment in People With Head and Neck Cancer, Psycho-Oncology, June 30, 2021,
19. *Mohtashami, S., Richardson, K., Forest, V., Mlynarek, A. ,Payne, R., Tamilia, M., Pusztaszeri, M., Hier, M., Sadeghi, N., Mascarella, M., Thyroidectomy for Graves’ Disease Predicts Postoperative Neck Hematoma and Hypocalcemia: A North American cohort study. Annals of Otol Rhinol Larygol. Accepted May 4, 2021,
20. *Mianroodi AA, Mohtashami S., Romero N., Fuson A., JoshiA., Sadeghi N., Autologous Free Dermal-Fat-Fascial Graft for Parotidectomy Defects, A Case Series, Annals of Otology, Rhinology, and Laryngology, 2021, Vol 131 (10) 1171-1180

21. Chen T, Gilfix B, Rivera JA, Sadeghi N, Richardson K, Hier MP, Forest VI, Fishman D, Caglar D, Pusztaszeri M, Mitmaker EJ, Payne RJ. The Role of the ThyroSeq v3 Molecular Test in the Surgical Management of Thyroid Nodules in the Canadian Public Healthcare Setting. Thyroid. 2020 Apr 3. Vol 30 (9), 1280-1287

22. *Sadeghi N, Mascarella MA, Khalife S, et al. Neoadjuvant chemotherapy followed by surgery for HPV‐associated locoregionally advanced oropharynx cancer. Head & Neck. 2020;42:2145–2154

23. *Sadeghi N., Khalife S., Mascarella M.A., Ramanakumar A.V., Richardson K., Joshi A.S., Bouganim N., Taheri R., Fuson A., Siegel R., Pathologic response to neoadjuvant chemotherapy in HPV-associated oropharynx cancer, Head Neck. 2020 Mar;42(3):417-425. doi:10.1002/hed.26022


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