Sabrina Wurzba

Image by JGH Audio Visual Department. .

sabrina.wurzba [at]

Sabrina Daniela Silva Wurzba, DDS, MSc, PhD

Faculty of Medicine

Department of Otolaryngology – Head and Neck Surgery

3755 Côte Ste-Catherine Road

Montreal, QC, H3T 1E2, Canada

Phone: 514-340-8222 ext.3432

Research Focus: Carcinogenesis, Cancer progression, Metastasis signaling, Preclinical and animal models, Genetic, Genomic and Epigenomic, Target and Drug Discovery

Dr Wurzba DDS, MSc, PhD is an assistant professor at the Department of Otolaryngology – Head and Neck Surgery at McGill University and project director at the Lady Davis Institute for Medical Research - Segal Cancer Center. She obtained her DDS degree from University of Sao Paulo State, Brazil and her MSc and PhD in Pathology and Molecular Biology at University of Campinas (UNICAMP, Brazil). She did a postdoctoral training in Genetic/Genomics in Oncology under supervision of Dr Luiz Paulo Kowalski, a renowned expert at AC Camargo Cancer Center, gaining a vast experience in the field. In 2010, she joined the ENT Department at the Jewish General Hospital where she continued her research focus on improving outcomes for patients with head and neck cancer through optimized detection and use of personalized targeted therapeutics. She pursued a complementary training in Experimental Medicine. In collaboration with Dr Moulay Alaoui-Jamali, a professor and scientist from the Segal Cancer Center and Lady Davis Institute for Medical Research, she carried out fundamental research to understand the mechanism of tumor progression including the establishment of orthotropic metastatic models using tissues samples from patients with head and neck cancer. In 2014, Dr. Wurzba became an assistant professor in the Department, where she is now leading basic and translational research with a primary goal to improve prevention, early tumor detection, and discover alternative therapeutic approaches for patients with advanced disease.

Dr Wurzba’s research has been published in several peer-reviewed biomedical and medical international journals and she has contributed to book chapters related to the field of oncology science. She has been presented at national and international conferences, including the American Association Head and Neck Society, the Canadian Society of Otolaryngology, and the International Academy of Oral Oncology. She also has been serving on several national and international grant panels, editorial boards of biomedical/medical journals.

At a Glance - Research activities

- The lab focuses on head and neck cancer genomics and translational applications;

- The lab seeks to apply innovative concepts of precision/personalized medicine both in the context of therapeutics and prevention;

- The lab is exploiting newer technologies to identify, understand and develop "smart" drugs against invasive head and neck cancer cells and their tissue microenvironment;

- The lab also studies drug resistance mechanisms associated with treatment failure and recurrences.

Supervision or co-supervision in the lab:

Faisal Alobaid (MD_ Saud-Arabia)

Jesse Popov (MD_Canada)

Shlomo Merchavy (MD_Israel)

Gregorie Morand (MD_ Switzerland)

Maisa Alkailane (MSc_Qatar)

Josh Lubov (Undergraduate_Canada)

Imam Ibrahim (MD_Egypt)

Paulo Bonan (DDS, MSc, PhD_Brazil)

Jessica Hier (Undergraduate_Canada)

Carol Carneiro (DDS, MSc_Brazil)

Recent selected publications:

Link to pubmed:

Bonan RF, Mota MF, da Costa Farias RM, da Silva SD, Bonan PRF, Diesel L, Menezes RR, da Cruz Perez DE.

In vitro antimicrobial and anticancer properties of TiO2 blow-spun nanofibers containing silver nanoparticles.

Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109876. Epub 2019 Jun 8.

doi: 10.1016/j.msec.2019.109876.


Semantic Data Integration Service for eHealth Applications.

Domingues A, Neto AS, Freitas A, Silva SD, Félix A, Neto FMM.

Stud Health Technol Inform. 2019 Aug 21;264:1454-1455.

doi: 10.3233/SHTI190481.


Flavonoids from Brazilian Cerrado: Biosynthesis, Chemical and Biological Profile.

Peixoto JC, Neves BJ, Vasconcelos FG, Napolitano HB, Barbalho MGDS, Silva SDE, Rosseto LP.

Molecules. 2019 Aug 9;24(16). pii: E2891.

doi: 10.3390/molecules24162891.


Mascarella MA, Azzi JL, da Silva SD, Mlynarek A, Forest VI, Hier M, Richardson K, Sadeghi N.

Postoperative infection predicts poor survival in locoregionally advanced oral cancer.

Head Neck. 2019 Oct;41(10):3624-3630. Epub 2019 Aug 5.

doi: 10.1002/hed.25885.


Ferreira-Junior NC, Ruggeri A, Silva SD Jr, Zampieri TT, Ceroni A, Michelini LC.

Exercise training increases GAD65 expression, restores the depressed GABAA receptor function within the PVN and reduces sympathetic modulation in hypertension.

Physiol Rep. 2019 Aug;7(13):e14107.

doi: 10.14814/phy2.14107.


Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD.

Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension.

Hypertension. 2019 Jul;74(1):173-183. Epub 2019 May 20.

doi: 10.1161/HYPERTENSIONAHA.119.13101.


Miguel RB, Albuquerque HG, Sanchez MCA, Coura JR, Santos SDS, Silva SD, Moreira CJC, Suárez-Mutis MC.

Asymptomatic Plasmodium infection in a residual malaria transmission area in the Atlantic Forest region: Implications for elimination.

Rev Soc Bras Med Trop. 2019 Mar 28;52:e20180537.

doi: 10.1590/0037-8682-0537-2018.


Chang CH, Bijian K, Wernic D, Su J, da Silva SD, Yu H, Qiu D, Asslan M, Alaoui-Jamali MA.

A novel orally available seleno-purine molecule suppresses triple-negative breast cancer cell proliferation and progression to metastasis by inducing cytostatic autophagy.

Autophagy. 2019 Aug;15(8):1376-1390. Epub 2019 Mar 1.

doi: 10.1080/15548627.2019.1582951.


da Silva SD, Kowalski LP.

Perineural invasion in oral cancer: challenges, controversies and clinical impact.

Chin Clin Oncol. 2018 Dec 4. pii: cco.2018.11.04. [Epub ahead of print] No abstract available.

doi: 10.21037/cco.2018.11.04.


Marques M, Jangal M, Wang LC, Kazanets A, da Silva SD, Zhao T, Lovato A, Yu H, Jie S, Del Rincon S, Mackey J, Damaraju S, Alaoui-Jamali M, Witcher M.

Oncogenic activity of poly (ADP-ribose) glycohydrolase.

Oncogene. 2019 Mar;38(12):2177-2191. Epub 2018 Nov 20.

doi: 10.1038/s41388-018-0568-6.


da Silva SD, Xu B, Maschietto M, Marchi FA, Alkailani MI, Bijian K, Xiao D, Alaoui-Jamali MA.

TRAF2 Cooperates with Focal Adhesion Signaling to Regulate Cancer Cell Susceptibility to Anoikis.

Mol Cancer Ther. 2019 Jan;18(1):139-146. Epub 2018 Oct 29.

doi: 10.1158/1535-7163.MCT-17-1261.


Vaccaro CA, López-Kostner F, Adriana DV, Palmero EI, Rossi BM, Antelo M, Solano A, Carraro DM, Forones NM, Bohorquez M, Lino-Silva LS, Buleje J, Spirandelli F, Abe-Sandes K, Nascimento I, Sullcahuaman Y, Sarroca C, Gonzalez ML, Herrando AI, Alvarez K, Neffa F, Galvão HC, Esperon P, Golubicki M, Cisterna D, Cardoso FC, Torrezan GT, Junior SA, Pimenta CAM, da Cruz Formiga MN, Santos E, Sá CU, Oliveira EP, Fujita R, Spirandelli E, Jimenez G, Guindalini RSC, de Azevedo RGMV, Bueno LSM, Dos Santos Nogueira ST, Loarte MT, Padron J, Del Carmen Castro-Mujica M, Del Monte JS, Caballero C, Peña CMM, Pinto J, Barletta-Carrillo C, Melva GA, Piñero T, Beltran PM, Ashton-Prolla P, Rodriguez Y, Quispe R, Rossi NT, Martin C, Chialina S, Kalfayan PG, Bazo-Alvarez JC, Cañete AR, Dominguez-Barrera C, Nuñez L, Da Silva SD, Balavarca Y, Wernhoff P, Plazzer JP, Møller P, Hovig E, Dominguez-Valentin M; in collaboration with GETH.

From colorectal cancer pattern to the characterization of individuals at risk: Picture for genetic research in Latin America.

Int J Cancer. 2019 Jul 15;145(2):318-326. Epub 2018 Dec 5. Review.

doi: 10.1002/ijc.31920.


Carnielli CM, Macedo CCS, De Rossi T, Granato DC, Rivera C, Domingues RR, Pauletti BA, Yokoo S, Heberle H, Busso-Lopes AF, Cervigne NK, Sawazaki-Calone I, Meirelles GV, Marchi FA, Telles GP, Minghim R, Ribeiro ACP, Brandão TB, de Castro G Jr, González-Arriagada WA, Gomes A, Penteado F, Santos-Silva AR, Lopes MA, Rodrigues PC, Sundquist E, Salo T, da Silva SD, Alaoui-Jamali MA, Graner E, Fox JW, Coletta RD, Paes Leme AF.

Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer.

Nat Commun. 2018 Sep 5;9(1):3598.

doi: 10.1038/s41467-018-05696-2.


Ibrahim I, Zeitouni A, da Silva SD.

Effect of Antioxidant Vitamins as Adjuvant Therapy for Sudden Sensorineural Hearing Loss: Systematic Review Study.

Audiol Neurootol. 2018;23(1):1-7. Epub 2018 Jun 22.

doi: 10.1159/000486274.


Ibrahim I, Dominguez-Valentin M, Segal B, Zeitouni A, da Silva SD.

Mitochondrial mutations associated with hearing and balance disorders.

Mutat Res. 2018 Jul;810:39-44. doi: 10.1016/j.mrfmmm.2018.03.003. Epub 2018 Mar 10. Review.

doi: 10.1016/j.mrfmmm.2018.03.003.


Katulanda P, Dissanayake HA, De Silva SDN, Katulanda GW, Liyanage IK, Constantine GR, Sheriff R, Matthews DR.

Prevalence, patterns, and associations of dyslipidemia among Sri Lankan adults-Sri Lanka Diabetes and Cardiovascular Study in 2005-2006.

J Clin Lipidol. 2018 Mar - Apr;12(2):447-454. Epub 2018 Jan 31.

doi: 10.1016/j.jacl.2018.01.006.


Mascarella MA, Mannard E, Silva SD, Zeitouni A.

Neutrophil-to-lymphocyte ratio in head and neck cancer prognosis: A systematic review and meta-analysis.

Head Neck. 2018 May;40(5):1091-1100. Epub 2018 Jan 22.

doi: 10.1002/hed.25075.


Silva SD Jr, Jara ZP, Peres R, Lima LS, Scavone C, Montezano AC, Touyz RM, Casarini DE, Michelini LC.

Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension: Role for local angiotensin II reduction.

PLoS One. 2017 Dec 12;12(12):e0189535. eCollection 2017.

doi: 10.1371/journal.pone.0189535.


Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, Żyłkiewicz E, Mikulski M, Brzózka K, Golas A, Kong Y, Ma M, Huang F, Huor B, Guo Q, da Silva SD, Torres J, Cai Y, Topisirovic I, Su J, Bijian K, Alaoui-Jamali MA, Huang S, Journe F, Ghanem GE, Miller WH Jr, Del Rincón SV.

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.

J Clin Invest. 2017 Nov 1;127(11):4179-4192. Epub 2017 Oct 16.

doi: 10.1172/JCI91258.


Maeda DLNF, Batista MT, Pereira LR, de Jesus Cintra M, Amorim JH, Mathias-Santos C, Pereira SA, Boscardin SB, Silva SDR, Faquim-Mauro EL, Silveira VB, Oliveira DBL, Johnston SA, Ferreira LCS, Rodrigues JF.

Adjuvant-Mediated Epitope Specificity and Enhanced Neutralizing Activity of Antibodies Targeting Dengue Virus Envelope Protein.

Front Immunol. 2017 Sep 25;8:1175. eCollection 2017.

doi: 10.3389/fimmu.2017.01175.


Lubov J, Maschietto M, Ibrahim I, Mlynarek A, Hier M, Kowalski LP, Alaoui-Jamali MA, da Silva SD.

Meta-analysis of microRNAs expression in head and neck cancer: uncovering association with outcome and mechanisms.

Oncotarget. 2017 Jul 13;8(33):55511-55524. eCollection 2017 Aug 15.

doi: 10.18632/oncotarget.19224.


Rossi BM, Palmero EI, López-Kostner F, Sarroca C, Vaccaro CA, Spirandelli F, Ashton-Prolla P, Rodriguez Y, de Campos Reis Galvão H, Reis RM, Escremim de Paula A, Capochin Romagnolo LG, Alvarez K, Della Valle A, Neffa F, Kalfayan PG, Spirandelli E, Chialina S, Gutiérrez Angulo M, Castro-Mujica MDC, Sanchez de Monte J, Quispe R, da Silva SD, Rossi NT, Barletta-Carrillo C, Revollo S, Taborga X, Morillas LL, Tubeuf H, Monteiro-Santos EM, Piñero TA, Dominguez-Barrera C, Wernhoff P, Martins A, Hovig E, Møller P, Dominguez-Valentin M.

A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America.

BMC Cancer. 2017 Sep 5;17(1):623.

doi: 10.1186/s12885-017-3599-4.


Serra MB, Barroso WA, da Silva NN, Silva SDN, Borges ACR, Abreu IC, Borges MODR.

From Inflammation to Current and Alternative Therapies Involved in Wound Healing.

Int J Inflam. 2017;2017:3406215. Epub 2017 Jul 25. Review.

doi: 10.1155/2017/3406215.


da Silva Alves GC, da Silva SD, Frade VP, Rodrigues D, Baldoni AO, de Castro WV, Sanches C.

Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis.

Eur J Clin Pharmacol. 2017 Nov;73(11):1341-1353. Epub 2017 Aug 4. Review.

doi: 10.1007/s00228-017-2306-3.


Lopes AM, Bobrowski VL, Silva SDDAE, Deuner S.

Morphophysiological and biochemical alterations in Ricinus communis L. seeds submitted to cobalt60 gamma radiation.

An Acad Bras Cienc. 2017 Jul-Sep;89(3):1925-1933. Epub 2017 Jul 31.

doi: 10.1590/0001-3765201720170081.


Ibrahim I, da Silva SD, Segal B, Zeitouni A.

Effect of cochlear implant surgery on vestibular function: meta-analysis study.

J Otolaryngol Head Neck Surg. 2017 Jun 8;46(1):44. Review.

doi: 10.1186/s40463-017-0224-0.


Silva SD, Carneiro RMDG, Faria M, Souza DA, Monnerat RG, Lopes RB.

Evaluation of Pochonia chlamydosporia and Purpureocillium lilacinum for Suppression of Meloidogyne enterolobii on Tomato and Banana.

J Nematol. 2017 Mar;49(1):77-85.



Morand GB, da Silva SD, Mlynarek AM, Black MJ, Payne RJ, Hier MP.

Clinicopathological relevance of antithyroglobulin antibodies in low-risk papillary thyroid cancer.

Clin Otolaryngol. 2017 Dec;42(6):1130-1134. Epub 2017 Mar 2.

doi: 10.1111/coa.12835.


Saad A, Bijian K, Qiu D, da Silva SD, Marques M, Chang CH, Nassour H, Ramotar D, Damaraju S, Mackey J, Bismar T, Witcher M, Alaoui-Jamali MA.

Insights into a novel nuclear function for Fascin in the regulation of the amino-acid transporter SLC3A2.

Sci Rep. 2016 Nov 7;6:36699.

doi: 10.1038/srep36699.


Silva SD, Flôres FS, Corrêa SL, Cordovil R, Copetti F.

Mother's Perception of Children's Motor Development in Southern Brazil.

Percept Mot Skills. 2017 Feb;124(1):72-85. Epub 2016 Nov 2.

doi: 10.1177/0031512516676203.


Silva SD, Bandeira AM, Tavares GG, Murari L.

The cerrado of Goiás in the literature of Bernardo Élis, from a viewpoint of environmental history.

Hist Cienc Saude Manguinhos. 2017 Jan-Mar;24(1):93-110. Epub 2016 Oct 10. Portuguese, English.

doi: 10.1590/S0104-59702016005000024.


Elias EV, de Castro NP, Pineda PH, Abuázar CS, Bueno de Toledo Osorio CA, Pinilla MG, da Silva SD, Camargo AA, Silva WA Jr, E Ferreira EN, Brentani HP, Carraro DM.

Epithelial cells captured from ductal carcinoma in situ reveal a gene expression signature associated with progression to invasive breast cancer.

Oncotarget. 2016 Nov 15;7(46):75672-75684. 12352.

doi: 10.18632/oncotarget.


Katulanda P, Hill NR, Stratton I, Sheriff R, De Silva SD, Matthews DR.

Development and validation of a Diabetes Risk Score for screening undiagnosed diabetes in Sri Lanka (SLDRISK).

BMC Endocr Disord. 2016 Jul 25;16(1):42.

doi: 10.1186/s12902-016-0124-8.


Saoudi S, Chammem N, Sifaoui I, Bouassida-Beji M, Jiménez IA, Bazzocchi IL, Silva SD, Hamdi M, Bronze MR.

Influence of Tunisian aromatic plants on the prevention of oxidation in soybean oil under heating and frying conditions.

Food Chem. 2016 Dec 1;212:503-11. Epub 2016 Jun 1.

doi: 10.1016/j.foodchem.2016.05.186.


Morand GB, Madana J, Da Silva SD, Roskies M, Sultanem K, Black MJ, Mlynarek AM, Hier MP.

Survival and quality of life in oropharyngeal cancer patients treated with primary chemoradiation after salivary gland transfer.

J Laryngol Otol. 2016 Aug;130(8):755-62. doi: 10.1017/S0022215116008100. Epub 2016 Jun 24.

doi: 10.1017/S0022215116008100.


Pontes AS, Setúbal Sda S, Nery NM, da Silva FS, da Silva SD, Fernandes CF, Stábeli RG, Soares AM, Zuliani JP.

p38 MAPK is involved in human neutrophil chemotaxis induced by L-amino acid oxidase from Calloselasma rhodosthoma.

Toxicon. 2016 Sep 1;119:106-16. doi: 10.1016/j.toxicon.2016.05.013. Epub 2016 May 27.

doi: 10.1016/j.toxicon.2016.05.013.


Morand GB, Madana J, Da Silva SD, Hier MP, Mlynarek AM, Black MJ.

Merkel cell carcinoma of the head and neck: poorer prognosis than non-head and neck sites.

J Laryngol Otol. 2016 Apr;130(4):393-7. doi: 10.1017/S0022215116000153. Epub 2016 Feb 15.

doi: 10.1017/S0022215116000153


Peralta RH, Velásquez JN, Cunha Fde S, Pantano ML, Sodré FC, Silva Sd, Astudillo OG, Peralta JM, Carnevale S.

Genetic diversity of Cryptosporidium identified in clinical samples from cities in Brazil and Argentina.

Mem Inst Oswaldo Cruz. 2016 Jan;111(1):30-6. doi: 10.1590/0074-02760150303.

doi: 10.1590/0074-02760150303


da Silva SD, Marchi FA, Xu B, Bijian K, Alobaid F, Mlynarek A, Rogatto SR, Hier M, Kowalski LP, Alaoui-Jamali MA.

Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis.

Oncotarget. 2015 Sep 8;6(26):21950-63.



Silva SD Jr, Zampieri TT, Ruggeri A, Ceroni A, Aragão DS, Fernandes FB, Casarini DE, Michelini LC.

Downregulation of the vascular renin-angiotensin system by aerobic training - focus on the balance between vasoconstrictor and vasodilator axes - .

Circ J. 2015;79(6):1372-80. doi: 10.1253/circj.CJ-14-1179. Epub 2015 Mar 25.

doi: 10.1253/circj.CJ-14-1179.


Alaoui-Jamali MA, Morand GB, da Silva SD.

ErbB polymorphisms: insights and implications for response to targeted cancer therapeutics.

Front Genet. 2015 Feb 4;6:17. doi: 10.3389/fgene.2015.00017. eCollection 2015. Review.

doi: 10.3389/fgene.2015.00017.


Galli V, Borowski JM, Perin EC, Messias Rda S, Labonde J, Pereira Idos S, Silva SD, Rombaldi CV.

Validation of reference genes for accurate normalization of gene expression for real time-quantitative PCR in strawberry fruits using different cultivars and osmotic stresses.

Gene. 2015 Jan 10;554(2):205-14. doi: 10.1016/j.gene.2014.10.049. Epub 2014 Oct 29.

doi: 10.1016/j.gene.2014.10.049


da Silva SD, Morand GB, Alobaid FA, Hier MP, Mlynarek AM, Alaoui-Jamali MA, Kowalski LP.

Epithelial-mesenchymal transition (EMT) markers have prognostic impact in multiple primary oral squamous cell carcinoma.

Clin Exp Metastasis. 2015 Jan;32(1):55-63. doi: 10.1007/s10585-014-9690-1. Epub 2014 Nov 30.

doi: 10.1007/s10585-014-9690-1


Morand GB, da Silva SD, Hier MP, Alaoui-Jamali MA.

Insights into genetic and epigenetic determinants with impact on vitamin d signaling and cancer association studies: the case of thyroid cancer.

Front Oncol. 2014 Nov 4;4:309. doi: 10.3389/fonc.2014.00309. eCollection 2014. Review.

doi: 10.3389/fonc.2014.00309.


Leandro LF, Cardoso MJ, Silva SD, Souza MG, Veneziani RC, Ambrosio SR, Martins CH.

Antibacterial activity of Pinus elliottii and its major compound, dehydroabietic acid, against multidrug-resistant strains.

J Med Microbiol. 2014 Dec;63(Pt 12):1649-53. doi: 10.1099/jmm.0.081711-0. Epub 2014 Sep 26.

doi: 10.1099/jmm.0.081711-0.


Miklowitz DJ, O'Brien MP, Schlosser DA, Addington J, Candan KA, Marshall C, Domingues I, Walsh BC, Zinberg JL, De Silva SD, Friedman-Yakoobian M, Cannon TD.

Family-focused treatment for adolescents and young adults at high risk for psychosis: results of a randomized trial.

J Am Acad Child Adolesc Psychiatry. 2014 Aug;53(8):848-58. doi: 10.1016/j.jaac.2014.04.020. Epub 2014 Jun 2.

doi: 10.1016/j.jaac.2014.04.020


Messias Rda S, Galli V, Silva SD, Schirmer MA, Rombaldi CV.

Micronutrient and functional compounds biofortification of maize grains.

Crit Rev Food Sci Nutr. 2015;55(1):123-39. doi: 10.1080/10408398.2011.649314. Review.

doi: 10.1080/10408398.2011.649314


Galli V, Guzman F, de Oliveira LF, Loss-Morais G, Körbes AP, Silva SD, Margis-Pinheiro MM, Margis R.

Identifying microRNAs and transcript targets in Jatropha seeds.

PLoS One. 2014 Feb 13;9(2):e83727. doi: 10.1371/journal.pone.0083727. eCollection 2014.

doi: 10.1371/journal.pone.0083727.


Pontes AS, da S Setúbal S, Xavier CV, Lacouth-Silva F, Kayano AM, Pires WL, Nery NM, Boeri de Castro O, da Silva SD, Calderon LA, Stábeli RG, Soares AM, Zuliani JP.

Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils.

Toxicon. 2014 Mar;80:27-37. doi: 10.1016/j.toxicon.2013.12.013. Epub 2014 Jan 21.

doi: 10.1016/j.toxicon.2013.12.013.


Xu B, Teng LH, Silva SD, Bijian K, Al Bashir S, Jie S, Dolph M, Alaoui-Jamali MA, Bismar TA.

The significance of dynamin 2 expression for prostate cancer progression, prognostication, and therapeutic targeting.

Cancer Med. 2014 Feb;3(1):14-24. doi: 10.1002/cam4.168. Epub 2013 Dec 18.

doi: 10.1002/cam4.168.


Silva SD, Feliciano RP, Boas LV, Bronze MR.

Application of FTIR-ATR to Moscatel dessert wines for prediction of total phenolic and flavonoid contents and antioxidant capacity.

Food Chem. 2014 May 1;150:489-93. doi: 10.1016/j.foodchem.2013.11.028. Epub 2013 Nov 15.

doi: 10.1016/j.foodchem.2013


Silva SD, Alaoui-Jamali MA, Hier M, Soares FA, Graner E, Kowalski LP.

Cooverexpression of ERBB1 and ERBB4 receptors predicts poor clinical outcome in pN+ oral squamous cell carcinoma with extranodal spread.

Clin Exp Metastasis. 2014 Mar;31(3):307-16. doi: 10.1007/s10585-013-9629-y. Epub 2013 Dec 15.

doi: 10.1007/s10585-013-9629-y


O'Brien MP, Miklowitz DJ, Candan KA, Marshall C, Domingues I, Walsh BC, Zinberg JL, De Silva SD, Woodberry KA, Cannon TD.

A randomized trial of family focused therapy with populations at clinical high risk for psychosis: effects on interactional behavior.

J Consult Clin Psychol. 2014 Feb;82(1):90-101. doi: 10.1037/a0034667. Epub 2013 Nov 4.

doi: 10.1037/a0034667


da Silva SD, Alaoui-Jamali MA, Soares FA, Carraro DM, Brentani HP, Hier M, Rogatto SR, Kowalski LP.

TWIST1 is a molecular marker for a poor prognosis in oral cancer and represents a potential therapeutic target.

Cancer. 2014 Feb 1;120(3):352-62. doi: 10.1002/cncr.28404. Epub 2013 Oct 21.

doi: 10.1002/cncr.28404.


da Silva SD, Hier M, Mlynarek A, Kowalski LP, Alaoui-Jamali MA.

Recurrent oral cancer: current and emerging therapeutic approaches.

Front Pharmacol. 2012 Jul 30;3:149. doi: 10.3389/fphar.2012.00149. eCollection 2012.

doi: 10.3389/fphar.2012.00149


Valentin MD, Da Silva FC, Santos EM, Da Silva SD, De Oliveira Ferreira F, Aguiar Junior S, Gomy I, Vaccaro C, Redal MA, Della Valle A, Sarroca C, Rasmussen LJ, Carraro DM, Rossi BM.

Evaluation of MLH1 I219V polymorphism in unrelated South American individuals suspected of having Lynch syndrome.

Anticancer Res. 2012 Oct;32(10):4347-51.


Silva SD, Nonogaki S, Soares FA, Kowalski LP.

p16 (INK4a) has clinicopathological and prognostic impact on oropharynx and larynx squamous cell carcinoma.

Braz J Med Biol Res. 2012 Dec;45(12):1327-33. Epub 2012 Sep 6.


Rolando RF, Silva Sd, Peralta RH, Silva AJ, Cunha Fde S, Bello AR, Peralta JM.

Detection and differentiation of Cryptosporidium by real-time polymerase chain reaction in stool samples from patients in Rio de Janeiro, Brazil.

Mem Inst Oswaldo Cruz. 2012 Jun;107(4):476-9.


Bitu CC, Destro MF, Carrera M, da Silva SD, Graner E, Kowalski LP, Soares FA, Coletta RD.

HOXA1 is overexpressed in oral squamous cell carcinomas and its expression is correlated with poor prognosis.

BMC Cancer. 2012 Apr 12;12:146. doi: 10.1186/1471-2407-12-146.

doi: 10.1186/1471-2407-12-146


Valentin MD, da Silva SD, Privat M, Alaoui-Jamali M, Bignon YJ.

Molecular insights on basal-like breast cancer.

Breast Cancer Res Treat. 2012 Jul;134(1):21-30. doi: 10.1007/s10549-011-1934-z. Epub 2012 Jan 11. Review.

doi: 10.1007/s10549-011-1934-z


Schlosser DA, Miklowitz DJ, O'Brien MP, De Silva SD, Zinberg JL, Cannon TD.

A randomized trial of family focused treatment for adolescents and young adults at risk for psychosis: study rationale, design and methods.

Early Interv Psychiatry. 2012 Aug;6(3):283-91. doi: 10.1111/j.1751-7893.2011.00317.x. Epub 2011 Dec 20.

doi: 10.1111/j.1751-7893.2011.00317.x


Mattioli TM, Silva Sd, Grégio AM, Machado MÂ, Lima AA, Alanis LR.

The effects of antidepressants and pilocarpine on rat parotid glands: an immunohistochemical study.

Clinics (Sao Paulo). 2011;66(9):1605-10.



da Silva SD, Ferlito A, Takes RP, Brakenhoff RH, Valentin MD, Woolgar JA, Bradford CR, Rodrigo JP, Rinaldo A, Hier MP, Kowalski LP.

Advances and applications of oral cancer basic research.

Oral Oncol. 2011 Sep;47(9):783-91. doi: 10.1016/j.oraloncology.2011.07.004. Epub 2011 Jul 29. Review.



Clinicopathological factors are predictors of distant metastasis from major salivary gland carcinomas.

Mariano FV, da Silva SD, Chulan TC, de Almeida OP, Kowalski LP.

Int J Oral Maxillofac Surg. 2011 May;40(5):504-9. doi: 10.1016/j.ijom.2010.12.002. Epub 2011 Jan 19.

doi: 10.1016/j.ijom.2010.12.


Costa Ade P, Bressan Cda S, Pedro RS, Valls-de-Souza R, Silva Sd, Souza PR, Guaraldo L, Ferreira-da-Cruz Mde F, Daniel-Ribeiro CT, Brasil P.

[Delayed diagnosis of malaria in a dengue endemic area in the Brazilian extra-Amazon: recent experience of a malaria surveillance unit in state of Rio de Janeiro].

Rev Soc Bras Med Trop. 2010 Sep-Oct;43(5):571-4. Portuguese.


Silva SD, Cunha IW, Younes RN, Soares FA, Kowalski LP, Graner E.

ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.

Oral Dis. 2010 Nov;16(8):774-80. doi: 10.1111/j.1601-0825.2010.01687.x.

doi: 10.1111/j.1601-0825.2010.01687.x


Ferreira EN, Maschietto M, Silva SD, Brentani H, Carraro DM.

Evaluation of quantitative rt-PCR using nonamplified and amplified RNA.

Diagn Mol Pathol. 2010 Mar;19(1):45-53. doi: 10.1097/PDM.0b013e3181ae8186.

doi: 10.1097/PDM.0b013e3181ae8186


Kaminagakura E, Vartanian JG, da Silva SD, dos Santos CR, Kowalski LP.

Case-control study on prognostic factors in oral squamous cell carcinoma in young patients.

Head Neck. 2010 Nov;32(11):1460-6. doi: 10.1002/hed.21347.

doi: 10.1002/hed.21347.


Calmon MF, Rodrigues RV, Kaneto CM, Moura RP, Silva SD, Mota LD, Pinheiro DG, Torres C, de Carvalho AF, Cury PM, Nunes FD, Nishimoto IN, Soares FA, da Silva AM, Kowalski LP, Brentani H, Zanelli CF, Silva WA Jr, Rahal P, Tajara EH, Carraro DM, Camargo AA, Valentini SR.

Epigenetic silencing of CRABP2 and MX1 in head and neck tumors.

Neoplasia. 2009 Dec;11(12):1329-39.


Dominguez MV, Bastos EP, Silva SD, Rossi BM.

[Molecular research methods in the detection of germinal mutations in hereditary colorectal cancer].

Rev Gastroenterol Peru. 2009 Jul-Sep;29(3):247-53. Review. Spanish.


Lourenço SV, A MS, Sotto MN, Bologna SB, Giacomo TB, Buim ME, Coutinho-Camillo CM, Silva SD, Landman G, Soares FA, Simonsen Nico MM.

Primary oral mucosal melanoma: a series of 35 new cases from South America.

Am J Dermatopathol. 2009 Jun;31(4):323-30. doi: 10.1097/DAD.0b013e3181a0d37c.

doi: 10.1097/DAD.0b013e3181a0d37c


Olivieri EH, da Silva SD, Mendonça FF, Urata YN, Vidal DO, Faria Mde A, Nishimoto IN, Rainho CA, Kowalski LP, Rogatto SR.

CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients.

Oral Oncol. 2009 Sep;45(9):e73-9. doi: 10.1016/j.oraloncology.2009.03.004. Epub 2009 May 12.

doi: 10.1016/j.oraloncology.2009.03.004


Aragão TP, Lyra MM, Silva MG, Andrade BA, Ferreira PA, Ortega LF, da Silva SD, da Silva JC, Fraga MC, Wanderley AG, Lafayette SS.

Toxicological reproductive study of Cassia occidentalis L. in female Wistar rats.

J Ethnopharmacol. 2009 May 4;123(1):163-6. doi: 10.1016/j.jep.2008.11.030. Epub 2009 Mar 6.

doi: 10.1016/j.jep.2008.11.030


da Silva SD, Cunha IW, Nishimoto IN, Soares FA, Carraro DM, Kowalski LP, Graner E.

Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.

Oral Oncol. 2009 Oct;45(10):e134-9. doi: 10.1016/j.oraloncology.2009.02.004. Epub 2009 Apr 9.

doi: 10.1016/j.oraloncology.2009.02.004


Silva SD, Cunha IW, Rangel AL, Jorge J, Zecchin KG, Agostini M, Kowalski LP, Coletta RD, Graner E.

Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes.

Virchows Arch. 2008 Jul;453(1):57-67. doi: 10.1007/s00428-008-0626-5. Epub 2008 Jun 6.

doi: 10.1007/s00428-008-0626-5.


Silva SD, Perez DE, Nishimoto IN, Alves FA, Pinto CA, Kowalski LP, Graner E.

Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings.

Oral Dis. 2008 May;14(4):376-82. doi: 10.1111/j.1601-0825.2007.01395.x.

doi: 10.1111/j.1601-0825.2007.01395.x


Kellermann MG, Sobral LM, da Silva SD, Zecchin KG, Graner E, Lopes MA, Nishimoto I, Kowalski LP, Coletta RD.

Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis.

Histopathology. 2007 Dec;51(6):849-53. No abstract available.


Kellermann MG, Sobral LM, da Silva SD, Zecchin KG, Graner E, Lopes MA, Kowalski LP, Coletta RD.

Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation.

Oral Oncol. 2008 May;44(5):509-17. Epub 2007 Sep 7.


Silva SD, Perez DE, Alves FA, Nishimoto IN, Pinto CA, Kowalski LP, Graner E.

ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: correlation with clinical outcomes.

Oral Oncol. 2008 May;44(5):484-90. Epub 2007 Sep 6.


Almeida JP, Coletta RD, Silva SD, Agostini M, Vargas PA, Bozzo L, Graner E.

Proliferation of fibroblasts cultured from normal gingiva and hereditary gingival fibromatosis is dependent on fatty acid synthase activity.

J Periodontol. 2005 Feb;76(2):272-8.


Mortara RA, Andreoli WK, Taniwaki NN, Fernandes AB, Silva CV, Fernandes MC, L'Abbate C, Silva Sd.

Mammalian cell invasion and intracellular trafficking by Trypanosoma cruzi infective forms.

An Acad Bras Cienc. 2005 Mar;77(1):77-94. Epub 2005 Feb 2. Review.


Agostini M, Silva SD, Zecchin KG, Coletta RD, Jorge J, Loda M, Graner E.

Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells.

Oral Oncol. 2004 Aug;40(7):728-35.


Silva SD, Agostini M, Nishimoto IN, Coletta RD, Alves FA, Lopes MA, Kowalski LP, Graner E.

Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study.

Oral Oncol. 2004 Aug;40(7):688-96.


Coutinho Ed Eda S, Silva SD.

[Medication as a risk factor for falls resulting in severe fractures in the elderly].

Cad Saude Publica. 2002 Sep-Oct;18(5):1359-66. Portuguese.


Coutinho ES, da Silva SD, Paiva CH, Freitas GG, Miranda LP, Mendonça R.

[Reliability of the information on the recent use of medication in a hospital based case-control study].

Cad Saude Publica. 1999 Jul-Sep;15(3):553-8. Portuguese.


Kale PA, Sathe SV, Rajani RM, Lokhandwala YY, Silva SD, Mehan VK, Kaneria VK, Kulkarni HL, Dalvi BV.

Long term results of percutaneous transluminal valvuloplasty in patients with valvular aortic stenosis.

Indian Heart J. 1992 Mar-Apr;44(2):67-70.


Veras RP, da Silva SD, Souza CA, Milioli R, Ventura F.

[Methodologic proposal for a domiciliary survey of the aged population in an urban center of the State of Rio de Janeiro (Brazil)].

Rev Saude Publica. 1989 Oct;23(5):429-38. Portuguese. Erratum in: Rev Saude Publica 1990 Apr;24(2):164.


Veras RP, Souza CA, Cardoso RF, Milioli R, da Silva SD.

[Research on elderly populations--the importance of the methods and training of the team: a methodologic contribution].

Rev Saude Publica. 1988 Dec;22(6):513-8. Portuguese. No abstract available.


Silva SD.

Methods for the study of the human foetal arterial system.

Acta Anat (Basel). 1986;126(4):208-11.


De OLIVEIRA CA, Deoliveira CA, Da Silva SD, Da Silva L, Rodrigues W.

[Hirschsprung disease (clinical and diagnostic aspects and treatment)].

Resen Clin Cient. 1969 Nov-Dec;38(11):288-93. Portuguese. No abstract available.


da Silva SD, da Silva LD.

[Various considerations on prevention and treatment of hepatic coma].

Hospital (Rio J). 1969 Nov;76(5):1767-72. Portuguese. No abstract available.

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