McGill.CA / Cystic Fibrosis Transmembrane Regulator Function Laboratory / Ongoing Projects

Alternative pathways for Cl- and HCO3- that could be used to bypass defective CFTR

 

 

A family of membrane proteins called the SLC26A mediate anion transport are expressed in airway epithelia and are potential targets for therapeutics to treat CF and other mucoobstructive diseases of the airways. We want to understand Cl- by SLC26A9 and HCO3- transport by SLC26A4, which strongly upregulated during inflammation.

Expression of SLC26A9 anion exchanger



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