ADP is used by the bacterial antibitiotic resistance enzyme APH(3’)-IIIa to detoxify aminoglycoside antibiotics. The fish-net surrounding the molecules is a representation of the experimentally observed electron density.
In gold is shown a ribbon representation of the enzyme, highlighting different secondary structure elements. The surface features of APH(3’)-IIIa are displayed as a semi-transparent film surrounding the molecule. Also shown is the co-factor ADP.
Shown is the molecular surface of the antibiotic resistance enzyme coloured by electrostatic potential, with red being negatively charged and blue being positively charged. The arrows surrounding the enzyme indicate the force which would be experienced by aminoglycoside antibiotics as a result of the particular surface properties of this enzyme.
This view highlights different secondary structure elements, the cysteine bridges conecting the two monomers, and the co-factors.
