Molecular surface of APH(3')-IIIa coloured based on electrostatic potential (blue = positive, red = negative) with Kanamycin (red sticks) and Neomycin (blue sticks)
ADP is used by the bacterial antibitiotic resistance enzyme APH(3’)-IIIa to detoxify aminoglycoside antibiotics. The fish-net surrounding the molecules is a representation of the experimentally...