Associate Professor - Reproductive Physiology
PhD (University of Saskatchewan)
BVSc, MVSc (University of Agri. Sci., Bangalore)
Raj Duggavathi obtained his BVSc (1997) and MVSc (1999) degrees from the University of Agricultural Sciences, Bangalore. He earned his PhD in reproductive physiology in 2004 from University of Saskatchewan, Saskatoon. Following a postdoctoral tenure at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Strasbourg, he joined the department of Animal Science in 2008. He serves as Chair of the Faculty Animal Care Committee and the Animal Science Safety committee.
Duggvathi’s research focuses on mechanisms of regulation of female fertility with emphasis on ovarian function. His group’s current research involves two modules. In module 1, they use bovine model to investigate metabolic regulation of ovarian function in dairy cows. In the last five years his group has discovered that metabolic indicators differ significantly between lactating dairy cows and non-lactating counterparts. Their current studies investigate the relationship between ovarian activity and bile acid/cholesterol metabolism. In module 2, they use genome edited and pharmacologically manipulated mouse models to investigate signaling pathways governing ovulation and fertility. In the last five years his group has discovered novel transcription factors involved in the ERK1/2 intracellular signaling pathways as well as important molecules involved in ovulation including Nr5a2, mTOR (both granulosa-specific knockout models) and Fabp6 (whole-body knockout model). Their current studies focus on the role of histone modifications in granulosa cell gene expression. They plan to use mice with granulosa-specific deletion of the genes of histone modifying enzymes and important promoter/enhancer regions involved in ovulation. For their studies, they employ both genomic and targeted gene approaches, including next-generation sequencing, chromatin immunoprecipitation, immunoblotting, quantitative-PCR in our studies. Their research will continue to advance the understanding of molecular mechanisms underpinning normal ovarian functions, including ovulation and steroid hormone production, leading to normal female fertility.
- Mechanisms that regulate ovarian functions
- Ovarian functions including somataic cell proliferation and differentiation; regulation of steroidogenesis; ovulation; corpus luteum development and regression
NSERC - Discovery
FQRNT - Nouveau Chercheur
CFI - LOF Individual
Yasmin Schuermann, PhD Candidate, “Metabolic and ovarian functions of lactating dairy cows”
Ejimedo Madogwe, PhD Candidate, “Role of histone modifications in the regulation of granulosa cell gene expression”
Milena Taibi, MSc Student, “FSH regulated signalling pathways in ovarian granulosa cells”
Audrey St-Yves, MSc Student, “Metabolic changes in lactating dairy cows”
We are always open for new PhD and post-doctoral trainees. Send your CV along with a statement of research interest to discuss funding possibilities.
Subramani E, Madogwe E, Ray CD, Dutta SK, Chakravarty B, Bordignon V, Duggavathi R*, Chaudhury K*. Dysregulated leukemia inhibitory factor and its receptor regulated signal transducers and activators of transcription 3 pathway: a possible cause for repeated implantation failure in women with dormant genital tuberculosis? Fertility and Sterility. 2016 105:1076-1084. * Co-corresponding authors
Ilha GF, Rovani MT, Gasperin BG, Antoniazzi AQ, Gonçalves PB, Bordignon V, Duggavathi R. Lack of FSH support enhances LIF-STAT3 signaling in granulosa cells of atretic follicles in cattle. Reproduction. 2015 150(4):395-403.
Siddappa D, Beaulieu É, Gévry N, Roux PP, Bordignon V, Duggavathi R. Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice. PLoS One. 2015 10(3):e0119387.
Duggavathi R, Siddappa D, Schuermann Y, Pansera M, Menard IJ, Praslickova D, Agellon LB. The fatty acid binding protein 6 gene (Fabp6) is expressed in murine granulosa cells and is involved in ovulatory response to superstimulation. Journal of Reproduction and Devevelopment. 2015 61(3):237-40.
Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP and Duggavathi R. Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice. Molecular Reproduction and Development 2014 81:655-65.
Sanchez R, Schuermann Y, Agellon LB, Baldassarre H, Bordignon V, Murphy BD, Gevry N, Praslickova D and Duggavathi R. Differential abundance of IGF1, bile acids, and the genes involved in their signaling in the dominant follicle microenvironment of lactating cows and nulliparous heifers. Theriogenology 2014 81:771-9.