Recent Publications

Vorstenbosch, J., H. Al-Ajmi, S. Winocour, A. Trzeciak, L. Lessard, and A. Philip. 2013. CD109 overexpression ameliorates skin fibrosis in a bleomycin-induced mouse model of scleroderma. Arthritis and Rheumatism. DOI: 10.1002/art.37907. Supplementary Figures Download

Vorstenbosch, J., C. Gallant-Behm, A. Trzeciak, S. Roy, T. Mustoe, and A. Philip. 2013. Transgenic mice overexpressing CD109 in the epidermis display decreased inflammation and granulation tissue and improved collagen architecture during wound healing. Wound Repair and Regeneration. 21:235-246.

Man, X.Y., K.W. Finnson, M. Baron, and A. Philip. 2012. CD109, a TGF-b co-receptor, attenuates extracellular matrix production in scleroderma skin fibroblasts. Arthritis Research & Therapy. 14:R144.

Bizet, A.A., N. Tran-Khanh, A. Saksena, K. Liu, M.D. Buschmann, and A. Philip. 2012. CD109-mediated degradation of the TGF-b receptors and inhibition of TGF-b responses involve regulation of Smad7 and Smurf2 localization and function. Journal of Cellular Biochemistry. 113:238-246.

Finnson, K., Y. Chi, G. Bou-Gharios, A. Leask, and A. Philip. 2012. TGF- b signaling in cartilage homeostasis and osteoarthritis. Frontiers in Bioscience. 4:251-268.

Finnson, K., Y. Chi, and A. Philip. 2012. TGF-b action in the cartilage health and disease. In Principles of Osteoarthritis- Its Definition, Character, Derivation and Modality-Related Recognition. D. Bruce Rothschild, editor. InTech. 497-516.

Finnson, K.W., and A. Philip. 2012. Endoglin in liver fibrosis. Journal of Cell Communication and Signaling. 6:1-4.

Bizet, A.A., K. Liu, N. Tran-Khanh, A. Saksena, J. Vorstenbosch, K.W. Finnson, M.D. Buschmann, and A. Philip. 2011. The TGF-b co-receptor, CD109, promotes internalization and degradation of TGF-b receptors. Biochim Biophys Acta: Molecular Cell Research. 1813:742-753.

Litvinov, I., A. Bizet, Y. Binamer, D. Jones, D. Sasseville, and A. Philip. 2011. CD109 release from the cell surface in human keratinocytes regulates TGF-b receptor expression, TGF-b signaling and STAT3 activation: relevance to psoriasis. Experimental Dermatology. 20:627-632

Finnson, K.W., W.L. Parker, Y. Chi, C. Hoemann, M.B. Goldring, J. Antoniou, and A. Philip. 2010. Endoglin differentially regulates TGF-b -induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes. Osteoarthritis and cartilage 18:1518-1527.

Finnson, K.W., W.L. Parker, P. ten Dijke, M. Thorikay, and A. Philip. 2008. ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes. J Bone Miner Res. 23:896-906.

Finnson, K.W., B.Y. Tam, K. Liu, A. Marcoux, P. Lepage, S. Roy, A.A. Bizet, and A. Philip. 2006. Identification of CD109 as part of the TGF-b receptor system in human keratinocytes. FASEB Journal. 20:1525-1527.