Recent Publications

Zhou S, Tabaries S, Siegel P, Philip A: CD109 drives tumorigenesis and metastasis by modulating EGFR/AKT signaling in squamous cell carcinoma. British journal of cancer 2021, pending revision.

Chi Y, Antoniou J, Philip A: Hypoxia differentially regulates ALK1 versus ALK5 signaling pathways in human chondrocytes. Osteoarthritis Cartilage 2021, pending revision.

Ghanbari F, Mader S, Philip A: Cholesterol as an endogenous ligand of ERRalpha promotes ERRalpha-mediated cellular proliferation and metabolic target gene expression in breast cancer cells. Cells 2020, 9(8):1765.

Zhou S, da Silva SD, Siegel PM, Philip A: CD109 acts as a gatekeeper of the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell carcinoma cells in vitro. Scientific reports 2019, 9(1):16317.

Istomine R, Alvarez F, Almadani Y, Philip A, Piccirillo CA: The deubiquitinating enzyme ubiquitin-specific peptidase 11 potentiates TGF-beta signaling in CD4(+) T Cells to facilitate Foxp3(+) regulatory T and TH17 cell differentiation. J Immunol 2019, 203(9):2388-2400.

Ghanbari F, Hebert-Losier A, Barry J, Poirier D, Giguere V, Mader S, Philip A: Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine. The Journal of steroid biochemistry and molecular biology 2019, 191:105352

Finnson KW, Almadani Y, Philip A: Non-canonical (non-SMAD2/3) TGF-beta signaling in fibrosis: mechanisms and targets. Semin Cell Dev Biol 2019, 101:115-122.

Alzahrani A, Chi Y, Finnson KW, Blati M, Lussier B, Kapoor M, Roy S, Philip A: Endoglin haploinsufficiency is associated with differential regulation of extracellular matrix production during skin fibrosis and cartilage repair in mice. J Cell Commun Signal 2018, 12(1):379-388.

Zhou S, Cecere R, Philip A: CD109 released from human bone marrow mesenchymal stem cells attenuates TGF-beta-induced epithelial to mesenchymal transition and stemness of squamous cell carcinoma. Oncotarget 2017, 8(56):95632-95647.

Vorstenbosch J, Nguyen CM, Zhou S, Seo YJ, Siblini A, Finnson KW, Bizet AA, Tran SD, Philip A: Overexpression of CD109 in the epidermis differentially regulates ALK1 versus ALK5 signaling and modulates extracellular matrix synthesis in the skin. The Journal of investigative dermatology 2017, 137(3):641-649.

Li C, Hancock M, Sehgal PB, Zhou S, Reinhardt D, Philip A: Soluble CD109 binds TGF-beta and antagonizes TGF-beta signaling and responses. Biochemical Journal 2016, 473(5):537-547.

Denis JF, Sader F, Gatien S, Villiard E, Philip A, Roy S: Activation of Smad2 but not Smad3 is required for mediating TGF-beta signaling during limb regeneration in axolotls. Development 2016, 143(19):3481-3490.


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